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MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells.
Mol Immunol. 2009 Jul; 46(11-12):2309-16.MI

Abstract

Mother-to-child transmission of human immunodeficiency virus-1 (HIV-1) occurs frequently via breast-feeding. HIV-1 targets DC-SIGN+ dendritic cells (DCs) in mucosal areas that allow efficient transmission of the virus to T cells. Here, we demonstrate that the epithelial mucin MUC1, abundant in milk, efficiently bound to DC-SIGN on DC. The O-linked glycans within the mucin domain contained Lewis X structures, that were specifically recognized by the receptor. Interestingly, MUC1 prevented DC-SIGN-mediated transmission of HIV-1 from DCs to CD4+ T cells. We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child.

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Authors+Show Affiliations

Saeland E
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands. e.saeland@vumc.nl
de Jong MA
No affiliation info available
Nabatov AA
No affiliation info available
Kalay H
No affiliation info available
Geijtenbeek TB
No affiliation info available
van Kooyk Y
No affiliation info available

MeSH

AnimalsCD4-Positive T-LymphocytesCHO CellsCell Adhesion MoleculesCricetinaeCricetulusDendritic CellsFemaleHIV Envelope Protein gp120HIV InfectionsHIV-1HumansInfectious Disease Transmission, VerticalLectins, C-TypeLewis X AntigenMilk, HumanMucin-1PregnancyReceptors, Cell Surface

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19406479

Citation

Saeland, Eirikur, et al. "MUC1 in Human Milk Blocks Transmission of Human Immunodeficiency Virus From Dendritic Cells to T Cells." Molecular Immunology, vol. 46, no. 11-12, 2009, pp. 2309-16.
Saeland E, de Jong MA, Nabatov AA, et al. MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells. Mol Immunol. 2009;46(11-12):2309-16.
Saeland, E., de Jong, M. A., Nabatov, A. A., Kalay, H., Geijtenbeek, T. B., & van Kooyk, Y. (2009). MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells. Molecular Immunology, 46(11-12), 2309-16. https://doi.org/10.1016/j.molimm.2009.03.025
Saeland E, et al. MUC1 in Human Milk Blocks Transmission of Human Immunodeficiency Virus From Dendritic Cells to T Cells. Mol Immunol. 2009;46(11-12):2309-16. PubMed PMID: 19406479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells. AU - Saeland,Eirikur, AU - de Jong,Marein A W P, AU - Nabatov,Alexey A, AU - Kalay,Hakan, AU - Geijtenbeek,Teunis B H, AU - van Kooyk,Yvette, Y1 - 2009/04/29/ PY - 2009/03/23/received PY - 2009/03/28/accepted PY - 2009/5/2/entrez PY - 2009/5/2/pubmed PY - 2009/8/6/medline SP - 2309 EP - 16 JF - Molecular immunology JO - Mol Immunol VL - 46 IS - 11-12 N2 - Mother-to-child transmission of human immunodeficiency virus-1 (HIV-1) occurs frequently via breast-feeding. HIV-1 targets DC-SIGN+ dendritic cells (DCs) in mucosal areas that allow efficient transmission of the virus to T cells. Here, we demonstrate that the epithelial mucin MUC1, abundant in milk, efficiently bound to DC-SIGN on DC. The O-linked glycans within the mucin domain contained Lewis X structures, that were specifically recognized by the receptor. Interestingly, MUC1 prevented DC-SIGN-mediated transmission of HIV-1 from DCs to CD4+ T cells. We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child. SN - 1872-9142 UR - https://www.unboundmedicine.com/medline/citation/19406479/MUC1_in_human_milk_blocks_transmission_of_human_immunodeficiency_virus_from_dendritic_cells_to_T_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-5890(09)00162-X DB - PRIME DP - Unbound Medicine ER -