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Iron prophylaxis in pregnancy: intravenous route versus oral route.
Eur J Obstet Gynecol Reprod Biol. 2009 Jun; 144(2):135-9.EJ

Abstract

OBJECTIVE

To assess and compare the efficacy and safety of two and three doses of intravenous iron sucrose with daily oral ferrous sulphate in the prophylaxis of iron deficiency anaemia in pregnant women.

STUDY DESIGN

260 women with singleton pregnancy who met inclusion criteria and who gave informed consent were randomised between the 21st and 24th week into either the intravenous iron group or the oral iron group. Of 130 women in the intravenous iron group, 75 women received two doses of 200mg iron sucrose and 55 three doses of 200mg iron sucrose. The first dose was administered between the 21st and 24th gestational weeks, the second between the 28th and 32nd and the third between the 35th and 37th. The women of the oral group were given oral tablets of 80 mg ferrous sulphate daily, beginning on the day of study enrolment and stopping on the day of delivery.

RESULTS

There was a non-significant trend to a higher frequency of responders (haemoglobin> or =11 g/dl) in the intravenous iron group (75 vs. 80%). There was a significant difference of repleted iron stores before delivery (ferritin>50 microg/l) in the group with three intravenous iron doses in comparison to the oral iron group (49 vs. 14%; p<0.001). No differences were observed in regard to maternal and perinatal outcomes.

CONCLUSIONS

There was no clinically significant difference in the haematological, maternal and foetal outcomes in the parenteral route of iron prophylaxis in pregnant women.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Institute of Obstetric Research, Zurich University Hospital, Switzerland. benca@bluewin.chNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase IV
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19406557

Citation

Bencaiova, Gabriela, et al. "Iron Prophylaxis in Pregnancy: Intravenous Route Versus Oral Route." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 144, no. 2, 2009, pp. 135-9.
Bencaiova G, von Mandach U, Zimmermann R. Iron prophylaxis in pregnancy: intravenous route versus oral route. Eur J Obstet Gynecol Reprod Biol. 2009;144(2):135-9.
Bencaiova, G., von Mandach, U., & Zimmermann, R. (2009). Iron prophylaxis in pregnancy: intravenous route versus oral route. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 144(2), 135-9. https://doi.org/10.1016/j.ejogrb.2009.03.006
Bencaiova G, von Mandach U, Zimmermann R. Iron Prophylaxis in Pregnancy: Intravenous Route Versus Oral Route. Eur J Obstet Gynecol Reprod Biol. 2009;144(2):135-9. PubMed PMID: 19406557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron prophylaxis in pregnancy: intravenous route versus oral route. AU - Bencaiova,Gabriela, AU - von Mandach,Ursula, AU - Zimmermann,Roland, Y1 - 2009/04/29/ PY - 2008/09/16/received PY - 2009/02/17/revised PY - 2009/03/10/accepted PY - 2009/5/2/entrez PY - 2009/5/2/pubmed PY - 2009/8/12/medline SP - 135 EP - 9 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur. J. Obstet. Gynecol. Reprod. Biol. VL - 144 IS - 2 N2 - OBJECTIVE: To assess and compare the efficacy and safety of two and three doses of intravenous iron sucrose with daily oral ferrous sulphate in the prophylaxis of iron deficiency anaemia in pregnant women. STUDY DESIGN: 260 women with singleton pregnancy who met inclusion criteria and who gave informed consent were randomised between the 21st and 24th week into either the intravenous iron group or the oral iron group. Of 130 women in the intravenous iron group, 75 women received two doses of 200mg iron sucrose and 55 three doses of 200mg iron sucrose. The first dose was administered between the 21st and 24th gestational weeks, the second between the 28th and 32nd and the third between the 35th and 37th. The women of the oral group were given oral tablets of 80 mg ferrous sulphate daily, beginning on the day of study enrolment and stopping on the day of delivery. RESULTS: There was a non-significant trend to a higher frequency of responders (haemoglobin> or =11 g/dl) in the intravenous iron group (75 vs. 80%). There was a significant difference of repleted iron stores before delivery (ferritin>50 microg/l) in the group with three intravenous iron doses in comparison to the oral iron group (49 vs. 14%; p<0.001). No differences were observed in regard to maternal and perinatal outcomes. CONCLUSIONS: There was no clinically significant difference in the haematological, maternal and foetal outcomes in the parenteral route of iron prophylaxis in pregnant women. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/19406557/Iron_prophylaxis_in_pregnancy:_intravenous_route_versus_oral_route_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(09)00199-7 DB - PRIME DP - Unbound Medicine ER -