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Cadmium exposure is associated with elevated blood C-reactive protein and fibrinogen in the U. S. population: the third national health and nutrition examination survey (NHANES III, 1988-1994).
Ann Epidemiol. 2009 Aug; 19(8):592-6.AE

Abstract

PURPOSE

Epidemiologic data suggest an association between cadmium exposure and cardiovascular disease though the underlying mechanisms remain unclear. This study explored the hypothesis that cadmium exposure is associated with elevated C-reactive protein (CRP) and fibrinogen, two risk factors for developing cardiovascular disease.

METHODS

The current study investigated associations between urinary cadmium and the prevalence of elevated blood CRP (> or = 2.2 mg/L) and fibrinogen (> or = 10.35 micromol/L) using data from a sample of 6497 participants aged 40-79 in the Third National Health and Nutrition Examination Survey. Logistic regression model was used to investigate existing associations while adjusting for confounding variables.

RESULTS

Both simple and covariate-adjusted models indicated that urinary cadmium was associated with elevated CRP and fibrinogen in a dose-dependent fashion (p(trend)<0.05 for both). Adjusted odds ratios for increased CRP and fibrinogen comparing highest with lowest quartiles of urinary cadmium were 1.62 (95% confidence interval [CI], 1.24-2.12) and 2.12 (1.43-3.14), respectively.

CONCLUSIONS

This analysis shows that cadmium exposure is associated with high prevalence of elevated CRP and fibrinogen. Additional study will be required to determine whether the increased risk derives from cadmium per se or from the environmental circumstances responsible for acquiring the contamination, e.g., cigarette smoking.

Authors+Show Affiliations

Department of Environmental and Occupational Health, University of North Texas Health Science Center, Fort Worth, TX 76107, USA. yulin@hsc.unt.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19406663

Citation

Lin, Yu-Sheng, et al. "Cadmium Exposure Is Associated With Elevated Blood C-reactive Protein and Fibrinogen in the U. S. Population: the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994)." Annals of Epidemiology, vol. 19, no. 8, 2009, pp. 592-6.
Lin YS, Rathod D, Ho WC, et al. Cadmium exposure is associated with elevated blood C-reactive protein and fibrinogen in the U. S. population: the third national health and nutrition examination survey (NHANES III, 1988-1994). Ann Epidemiol. 2009;19(8):592-6.
Lin, Y. S., Rathod, D., Ho, W. C., & Caffrey, J. J. (2009). Cadmium exposure is associated with elevated blood C-reactive protein and fibrinogen in the U. S. population: the third national health and nutrition examination survey (NHANES III, 1988-1994). Annals of Epidemiology, 19(8), 592-6. https://doi.org/10.1016/j.annepidem.2009.02.005
Lin YS, et al. Cadmium Exposure Is Associated With Elevated Blood C-reactive Protein and Fibrinogen in the U. S. Population: the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994). Ann Epidemiol. 2009;19(8):592-6. PubMed PMID: 19406663.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cadmium exposure is associated with elevated blood C-reactive protein and fibrinogen in the U. S. population: the third national health and nutrition examination survey (NHANES III, 1988-1994). AU - Lin,Yu-Sheng, AU - Rathod,Dhruv, AU - Ho,Wen-Chao, AU - Caffrey,James J, Y1 - 2009/05/05/ PY - 2008/10/31/received PY - 2009/02/06/revised PY - 2009/02/10/accepted PY - 2009/5/2/entrez PY - 2009/5/2/pubmed PY - 2009/9/23/medline SP - 592 EP - 6 JF - Annals of epidemiology JO - Ann Epidemiol VL - 19 IS - 8 N2 - PURPOSE: Epidemiologic data suggest an association between cadmium exposure and cardiovascular disease though the underlying mechanisms remain unclear. This study explored the hypothesis that cadmium exposure is associated with elevated C-reactive protein (CRP) and fibrinogen, two risk factors for developing cardiovascular disease. METHODS: The current study investigated associations between urinary cadmium and the prevalence of elevated blood CRP (> or = 2.2 mg/L) and fibrinogen (> or = 10.35 micromol/L) using data from a sample of 6497 participants aged 40-79 in the Third National Health and Nutrition Examination Survey. Logistic regression model was used to investigate existing associations while adjusting for confounding variables. RESULTS: Both simple and covariate-adjusted models indicated that urinary cadmium was associated with elevated CRP and fibrinogen in a dose-dependent fashion (p(trend)<0.05 for both). Adjusted odds ratios for increased CRP and fibrinogen comparing highest with lowest quartiles of urinary cadmium were 1.62 (95% confidence interval [CI], 1.24-2.12) and 2.12 (1.43-3.14), respectively. CONCLUSIONS: This analysis shows that cadmium exposure is associated with high prevalence of elevated CRP and fibrinogen. Additional study will be required to determine whether the increased risk derives from cadmium per se or from the environmental circumstances responsible for acquiring the contamination, e.g., cigarette smoking. SN - 1873-2585 UR - https://www.unboundmedicine.com/medline/citation/19406663/Cadmium_exposure_is_associated_with_elevated_blood_C_reactive_protein_and_fibrinogen_in_the_U__S__population:_the_third_national_health_and_nutrition_examination_survey__NHANES_III_1988_1994__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(09)00071-4 DB - PRIME DP - Unbound Medicine ER -