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Long-term wine consumption is related to cardiovascular mortality and life expectancy independently of moderate alcohol intake: the Zutphen Study.

Abstract

BACKGROUND

Light to moderate alcohol intake lowers the risk of cardiovascular mortality, but whether this protective effect can be attributed to a specific type of beverage remains unclear. Moreover, little is known about the effects of long-term alcohol intake on life expectancy.

METHODS

The impact of long-term alcohol intake and types of alcoholic beverages consumed on cardiovascular mortality and life expectancy at age 50 was investigated in the Zutphen Study, a cohort of 1373 men born between 1900 and 1920 and examined repeatedly between 1960 and 2000. Hazard ratios (HRs) for total alcohol intake and alcohol from wine, beer and spirits were obtained from time-dependent Cox regression models. Life expectancy at age 50 was calculated from areas under survival curves.

RESULTS

Long-term light alcohol intake, that is < or =20 g per day, compared with no alcohol, was strongly and inversely associated with cerebrovascular (HR 0.43, 95% CI 0.26 to 0.70), total cardiovascular (HR 0.70, 95% CI 0.55 to 0.89) and all-cause mortality (HR 0.75, 95% CI 0.63 to 0.91). Independent of total alcohol intake, long-term wine consumption of, on average, less than half a glass per day was strongly and inversely associated with coronary heart disease (HR 0.61, 95% CI 0.41 to 0.89), total cardiovascular (HR 0.68, 95% CI 0.53 to 0.86) and all-cause mortality (HR 0.73, 95% CI 0.62 to 0.87). These results could not be explained by differences in socioeconomic status. Life expectancy was about 5 years longer in men who consumed wine compared with those who did not use alcoholic beverages.

CONCLUSION

Long-term light alcohol intake lowered cardiovascular and all-cause mortality risk and increased life expectancy. Light wine consumption was associated with 5 years longer life expectancy; however, more studies are needed to verify this result.

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  • Authors+Show Affiliations

    ,

    National Institute for Public Health and Environment (RIVM), Bilthoven, The Netherlands. martinette.streppel@wur.nl

    , , ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Alcohol Drinking
    Alcoholic Beverages
    Cardiovascular Diseases
    Cause of Death
    Cerebrovascular Disorders
    Cohort Studies
    Coronary Artery Disease
    Humans
    Life Expectancy
    Male
    Middle Aged
    Netherlands
    Risk Factors
    Social Class
    Time Factors
    Wine

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19406740

    Citation

    Streppel, M T., et al. "Long-term Wine Consumption Is Related to Cardiovascular Mortality and Life Expectancy Independently of Moderate Alcohol Intake: the Zutphen Study." Journal of Epidemiology and Community Health, vol. 63, no. 7, 2009, pp. 534-40.
    Streppel MT, Ocké MC, Boshuizen HC, et al. Long-term wine consumption is related to cardiovascular mortality and life expectancy independently of moderate alcohol intake: the Zutphen Study. J Epidemiol Community Health. 2009;63(7):534-40.
    Streppel, M. T., Ocké, M. C., Boshuizen, H. C., Kok, F. J., & Kromhout, D. (2009). Long-term wine consumption is related to cardiovascular mortality and life expectancy independently of moderate alcohol intake: the Zutphen Study. Journal of Epidemiology and Community Health, 63(7), pp. 534-40. doi:10.1136/jech.2008.082198.
    Streppel MT, et al. Long-term Wine Consumption Is Related to Cardiovascular Mortality and Life Expectancy Independently of Moderate Alcohol Intake: the Zutphen Study. J Epidemiol Community Health. 2009;63(7):534-40. PubMed PMID: 19406740.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Long-term wine consumption is related to cardiovascular mortality and life expectancy independently of moderate alcohol intake: the Zutphen Study. AU - Streppel,M T, AU - Ocké,M C, AU - Boshuizen,H C, AU - Kok,F J, AU - Kromhout,D, Y1 - 2009/04/30/ PY - 2009/5/2/entrez PY - 2009/5/2/pubmed PY - 2010/6/19/medline SP - 534 EP - 40 JF - Journal of epidemiology and community health JO - J Epidemiol Community Health VL - 63 IS - 7 N2 - BACKGROUND: Light to moderate alcohol intake lowers the risk of cardiovascular mortality, but whether this protective effect can be attributed to a specific type of beverage remains unclear. Moreover, little is known about the effects of long-term alcohol intake on life expectancy. METHODS: The impact of long-term alcohol intake and types of alcoholic beverages consumed on cardiovascular mortality and life expectancy at age 50 was investigated in the Zutphen Study, a cohort of 1373 men born between 1900 and 1920 and examined repeatedly between 1960 and 2000. Hazard ratios (HRs) for total alcohol intake and alcohol from wine, beer and spirits were obtained from time-dependent Cox regression models. Life expectancy at age 50 was calculated from areas under survival curves. RESULTS: Long-term light alcohol intake, that is < or =20 g per day, compared with no alcohol, was strongly and inversely associated with cerebrovascular (HR 0.43, 95% CI 0.26 to 0.70), total cardiovascular (HR 0.70, 95% CI 0.55 to 0.89) and all-cause mortality (HR 0.75, 95% CI 0.63 to 0.91). Independent of total alcohol intake, long-term wine consumption of, on average, less than half a glass per day was strongly and inversely associated with coronary heart disease (HR 0.61, 95% CI 0.41 to 0.89), total cardiovascular (HR 0.68, 95% CI 0.53 to 0.86) and all-cause mortality (HR 0.73, 95% CI 0.62 to 0.87). These results could not be explained by differences in socioeconomic status. Life expectancy was about 5 years longer in men who consumed wine compared with those who did not use alcoholic beverages. CONCLUSION: Long-term light alcohol intake lowered cardiovascular and all-cause mortality risk and increased life expectancy. Light wine consumption was associated with 5 years longer life expectancy; however, more studies are needed to verify this result. SN - 1470-2738 UR - https://www.unboundmedicine.com/medline/citation/19406740/Long_term_wine_consumption_is_related_to_cardiovascular_mortality_and_life_expectancy_independently_of_moderate_alcohol_intake:_the_Zutphen_Study_ L2 - http://jech.bmj.com/cgi/pmidlookup?view=long&amp;pmid=19406740 DB - PRIME DP - Unbound Medicine ER -