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Effects of delta9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress.
J Psychopharmacol 2010; 24(5):767-77JP

Abstract

Although cannabis derivatives produce clear subjective motivational responses in humans leading to drug-seeking behaviour, the reinforcing attributes of these subjective effects are difficult to define in experimental animals. The aim of this study was to examine how exposure to chronic unpredictable stress (CUS) will affect reward function and anxiety after acute administration of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in rats. Male rats were exposed to either 10 days of CUS or no stressor. Alterations in brain reward function were assessed with the intracranial self-stimulation (ICSS) paradigm, and anxiety responses were measured with the elevated plus maze. CUS did not affect baseline brain stimulation reward thresholds. Delta(9)-THC did not exhibit reinforcing actions in the ICSS paradigm neither in nonstressed nor in stressed animals. More importantly, in nonstressed animals, both the low and the high dose of Delta(9)-THC exerted anxiolytic-like effects. In stressed animals, however, only the high dose of THC induced an anxiolytic-like response, whereas the low dose induced anxiogenic effects. The present results provide clear evidence for an anxiolytic effect of Delta(9)-THC both in stressed and in nonstressed animals, and indicate that environmental conditions, such as stressful experiences, do not alter the behavioural effects of Delta(9)-THC in the ICSS paradigm.

Authors+Show Affiliations

Laboratory of Behavioral Neuroscience, Department of Psychology, School of Social Sciences, University of Crete, Crete, Greece.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19406854

Citation

Fokos, S, and G Panagis. "Effects of Delta9-tetrahydrocannabinol On Reward and Anxiety in Rats Exposed to Chronic Unpredictable Stress." Journal of Psychopharmacology (Oxford, England), vol. 24, no. 5, 2010, pp. 767-77.
Fokos S, Panagis G. Effects of delta9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress. J Psychopharmacol (Oxford). 2010;24(5):767-77.
Fokos, S., & Panagis, G. (2010). Effects of delta9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress. Journal of Psychopharmacology (Oxford, England), 24(5), pp. 767-77. doi:10.1177/0269881109104904.
Fokos S, Panagis G. Effects of Delta9-tetrahydrocannabinol On Reward and Anxiety in Rats Exposed to Chronic Unpredictable Stress. J Psychopharmacol (Oxford). 2010;24(5):767-77. PubMed PMID: 19406854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of delta9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress. AU - Fokos,S, AU - Panagis,G, Y1 - 2009/04/30/ PY - 2009/5/2/entrez PY - 2009/5/2/pubmed PY - 2010/8/19/medline SP - 767 EP - 77 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 24 IS - 5 N2 - Although cannabis derivatives produce clear subjective motivational responses in humans leading to drug-seeking behaviour, the reinforcing attributes of these subjective effects are difficult to define in experimental animals. The aim of this study was to examine how exposure to chronic unpredictable stress (CUS) will affect reward function and anxiety after acute administration of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in rats. Male rats were exposed to either 10 days of CUS or no stressor. Alterations in brain reward function were assessed with the intracranial self-stimulation (ICSS) paradigm, and anxiety responses were measured with the elevated plus maze. CUS did not affect baseline brain stimulation reward thresholds. Delta(9)-THC did not exhibit reinforcing actions in the ICSS paradigm neither in nonstressed nor in stressed animals. More importantly, in nonstressed animals, both the low and the high dose of Delta(9)-THC exerted anxiolytic-like effects. In stressed animals, however, only the high dose of THC induced an anxiolytic-like response, whereas the low dose induced anxiogenic effects. The present results provide clear evidence for an anxiolytic effect of Delta(9)-THC both in stressed and in nonstressed animals, and indicate that environmental conditions, such as stressful experiences, do not alter the behavioural effects of Delta(9)-THC in the ICSS paradigm. SN - 1461-7285 UR - https://www.unboundmedicine.com/medline/citation/19406854/abstract/Effects_of_{Delta}9_tetrahydrocannabinol_on_reward_and_anxiety_in_rats_exposed_to_chronic_unpredictable_stress_ DB - PRIME DP - Unbound Medicine ER -