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A yeast hybrid provides insight into the evolution of gene expression regulation.
Science. 2009 May 01; 324(5927):659-62.Sci

Abstract

During evolution, novel phenotypes emerge through changes in gene expression, but the genetic basis is poorly understood. We compared the allele-specific expression of two yeast species and their hybrid, which allowed us to distinguish changes in regulatory sequences of the gene itself (cis) from changes in upstream regulatory factors (trans). Expression divergence between species was generally due to changes in cis. Divergence in trans reflected a differential response to the environment and explained the tendency of certain genes to diverge rapidly. Hybrid-specific expression, deviating from the parental range, occurred through novel cis-trans interactions or, more often, through modified trans regulation associated with environmental sensing. These results provide insights on the regulatory changes in cis and trans during the divergence of species and upon hybridization.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Tirosh I
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Reikhav S
No affiliation info available
Levy AA
No affiliation info available
Barkai N
No affiliation info available

MeSH

Culture MediaEvolution, MolecularGene Expression ProfilingGene Expression Regulation, FungalGenes, FungalGenetic VariationGenome, FungalGlycerolHot TemperatureHybridization, GeneticMutationOligonucleotide Array Sequence AnalysisPromoter Regions, GeneticRegulatory Sequences, Nucleic AcidSaccharomycesSaccharomyces cerevisiaeSpecies SpecificityTATA Box

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19407207

Citation

Tirosh, Itay, et al. "A Yeast Hybrid Provides Insight Into the Evolution of Gene Expression Regulation." Science (New York, N.Y.), vol. 324, no. 5927, 2009, pp. 659-62.
Tirosh I, Reikhav S, Levy AA, et al. A yeast hybrid provides insight into the evolution of gene expression regulation. Science. 2009;324(5927):659-62.
Tirosh, I., Reikhav, S., Levy, A. A., & Barkai, N. (2009). A yeast hybrid provides insight into the evolution of gene expression regulation. Science (New York, N.Y.), 324(5927), 659-62. https://doi.org/10.1126/science.1169766
Tirosh I, et al. A Yeast Hybrid Provides Insight Into the Evolution of Gene Expression Regulation. Science. 2009 May 1;324(5927):659-62. PubMed PMID: 19407207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A yeast hybrid provides insight into the evolution of gene expression regulation. AU - Tirosh,Itay, AU - Reikhav,Sharon, AU - Levy,Avraham A, AU - Barkai,Naama, PY - 2009/5/2/entrez PY - 2009/5/2/pubmed PY - 2009/5/14/medline SP - 659 EP - 62 JF - Science (New York, N.Y.) JO - Science VL - 324 IS - 5927 N2 - During evolution, novel phenotypes emerge through changes in gene expression, but the genetic basis is poorly understood. We compared the allele-specific expression of two yeast species and their hybrid, which allowed us to distinguish changes in regulatory sequences of the gene itself (cis) from changes in upstream regulatory factors (trans). Expression divergence between species was generally due to changes in cis. Divergence in trans reflected a differential response to the environment and explained the tendency of certain genes to diverge rapidly. Hybrid-specific expression, deviating from the parental range, occurred through novel cis-trans interactions or, more often, through modified trans regulation associated with environmental sensing. These results provide insights on the regulatory changes in cis and trans during the divergence of species and upon hybridization. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/19407207/A_yeast_hybrid_provides_insight_into_the_evolution_of_gene_expression_regulation_ DB - PRIME DP - Unbound Medicine ER -