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Plasma visfatin level in lean women with PCOS: relation to proinflammatory markers and insulin resistance.
Gynecol Endocrinol. 2009 Apr; 25(4):241-5.GE

Abstract

OBJECTIVES

The present study was undertaken to investigate the association between plasma visfatin concentrations and inflammatory markers such as interleukin-6 (IL-6) and high-sensitive C-reactive protein (hsCRP) in company with several metabolic parameters in lean women with polycystic ovary syndrome (PCOS).

METHODS

The study group consisted of 21 lean women with PCOS (BMI 20.74 +/- 1.74 kg/m(2)) and 15 healthy, normally menstruating women (BMI 20.85 +/- 2.08 kg/m(2) control group). PCOS was defined according to the Rotterdam criteria. Visfatin, IL-6, hsCRP, hyperandrogenism markers and metabolic markers were examined in all PCOS and control women.

RESULTS

Plasma visfatin level in the PCOS group was higher than that in the control group. Plasma hsCRP and IL-6 levels in PCOS group were similar with the control group. Plasma visfatin levels were positively associated with total cholesterol, high density lipoprotein, hirsutism score, total testosterone and FAI. Plasma visfatin level was negatively associated with SHBG. However, there were no correlation between plasma visfatin level and IL-6 and hsCRP. In multivariate regression analyses, only FAI and high density lipoprotein-cholesterol (HDL-C) showed a significant association with serum visfatin.

CONCLUSION

Our data indicates that plasma visfatin levels are associated with HDL-C and markers of hyperandrogenism, but it is not associated with proinflammatory markers and insulin resistance in lean women with PCOS.

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Authors+Show Affiliations

Gen R
Department of Endocrinology and Metabolism, Mersin University, Mersin, Turkey. ramazangen@mersin.edu.tr
Akbay E
No affiliation info available
Muslu N
No affiliation info available
Sezer K
No affiliation info available
Cayan F
No affiliation info available

MeSH

AdultBiomarkersBody WeightC-Reactive ProteinFemaleHormonesHumansInsulin ResistanceInterleukin-6LipidsMenstruationMultivariate AnalysisNicotinamide PhosphoribosyltransferasePolycystic Ovary SyndromeRegression AnalysisYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19408173

Citation

Gen, Ramazan, et al. "Plasma Visfatin Level in Lean Women With PCOS: Relation to Proinflammatory Markers and Insulin Resistance." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 25, no. 4, 2009, pp. 241-5.
Gen R, Akbay E, Muslu N, et al. Plasma visfatin level in lean women with PCOS: relation to proinflammatory markers and insulin resistance. Gynecol Endocrinol. 2009;25(4):241-5.
Gen, R., Akbay, E., Muslu, N., Sezer, K., & Cayan, F. (2009). Plasma visfatin level in lean women with PCOS: relation to proinflammatory markers and insulin resistance. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 25(4), 241-5. https://doi.org/10.1080/09513590802585613
Gen R, et al. Plasma Visfatin Level in Lean Women With PCOS: Relation to Proinflammatory Markers and Insulin Resistance. Gynecol Endocrinol. 2009;25(4):241-5. PubMed PMID: 19408173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma visfatin level in lean women with PCOS: relation to proinflammatory markers and insulin resistance. AU - Gen,Ramazan, AU - Akbay,Esen, AU - Muslu,Necati, AU - Sezer,Kerem, AU - Cayan,Filiz, PY - 2009/5/2/entrez PY - 2009/5/2/pubmed PY - 2009/7/16/medline SP - 241 EP - 5 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 25 IS - 4 N2 - OBJECTIVES: The present study was undertaken to investigate the association between plasma visfatin concentrations and inflammatory markers such as interleukin-6 (IL-6) and high-sensitive C-reactive protein (hsCRP) in company with several metabolic parameters in lean women with polycystic ovary syndrome (PCOS). METHODS: The study group consisted of 21 lean women with PCOS (BMI 20.74 +/- 1.74 kg/m(2)) and 15 healthy, normally menstruating women (BMI 20.85 +/- 2.08 kg/m(2) control group). PCOS was defined according to the Rotterdam criteria. Visfatin, IL-6, hsCRP, hyperandrogenism markers and metabolic markers were examined in all PCOS and control women. RESULTS: Plasma visfatin level in the PCOS group was higher than that in the control group. Plasma hsCRP and IL-6 levels in PCOS group were similar with the control group. Plasma visfatin levels were positively associated with total cholesterol, high density lipoprotein, hirsutism score, total testosterone and FAI. Plasma visfatin level was negatively associated with SHBG. However, there were no correlation between plasma visfatin level and IL-6 and hsCRP. In multivariate regression analyses, only FAI and high density lipoprotein-cholesterol (HDL-C) showed a significant association with serum visfatin. CONCLUSION: Our data indicates that plasma visfatin levels are associated with HDL-C and markers of hyperandrogenism, but it is not associated with proinflammatory markers and insulin resistance in lean women with PCOS. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/19408173/Plasma_visfatin_level_in_lean_women_with_PCOS:_relation_to_proinflammatory_markers_and_insulin_resistance_ L2 - https://www.tandfonline.com/doi/full/10.1080/09513590802585613 DB - PRIME DP - Unbound Medicine ER -