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Serum resistin and adiponectin levels in women with polycystic ovary syndrome.
Gynecol Endocrinol 2009; 25(4):246-52GE

Abstract

AIM

This study was performed to compare the serum levels of resistin and adiponectin in women with polycystic ovary syndrome (PCOS) and normal controls.

MATERIALS AND METHODS

Seventy-six patients (36 obese, 40 non-obese) with PCOS and 42 healthy subjects were included in the study. Serum levels of resistin, adiponectin, follicle-stimulating hormone, luteinising hormone, dehydroepiandrosterone sulfate (DHEA-S), 17-hydroxy progesterone, free testosterone, androstenedione, glucose, insulin and lipid parameters were measured. Insulin resistance and carbohydrate metabolism were evaluated by using the homeostasis model (HOMA) and the area under the insulin curve (AUCI).

RESULTS

Plasma resistin levels, HOMA-IR and AUCI were significantly higher and adiponectin level was lower in women with PCOS than those in healthy women. Plasma resistin levels were similar among obese and non-obese women with PCOS. No correlation was observed between resistin, body mass index (BMI), HOMA-IR, AUCI, insulin, lipid parameters and serum androgen levels. In obese PCOS patients, adiponectin levels were lower than in the lean PCOS patients. A negative correlation was observed among adiponectin, HOMA-IR, AUCI, BMI, testosterone, DHEAS, total-cholesterol, LDL-cholesterol and lipoprotein (a) levels.

CONCLUSION

These results suggest that the serum adiponectin level may be involved in the pathogenesis of PCOS. But resistin levels were independently associated with insulin resistance and BMI in PCOS patients. Nevertheless, wider-scale trials are required to be performed on this subject.

Authors+Show Affiliations

Faculty of Medicine, Department of Endocrinology and Metabolism, Kýrýkkale University, Kýrýkkale, Turkey. murartt@hotmail.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19408174

Citation

Yilmaz, Murat, et al. "Serum Resistin and Adiponectin Levels in Women With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 25, no. 4, 2009, pp. 246-52.
Yilmaz M, Bukan N, Demirci H, et al. Serum resistin and adiponectin levels in women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25(4):246-52.
Yilmaz, M., Bukan, N., Demirci, H., Oztürk, C., Kan, E., Ayvaz, G., & Arslan, M. (2009). Serum resistin and adiponectin levels in women with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 25(4), pp. 246-52. doi:10.1080/09513590802653833.
Yilmaz M, et al. Serum Resistin and Adiponectin Levels in Women With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2009;25(4):246-52. PubMed PMID: 19408174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum resistin and adiponectin levels in women with polycystic ovary syndrome. AU - Yilmaz,Murat, AU - Bukan,Neslihan, AU - Demirci,Hüseyin, AU - Oztürk,Ciğdem, AU - Kan,Erdal, AU - Ayvaz,Göksun, AU - Arslan,Metin, PY - 2009/5/2/entrez PY - 2009/5/2/pubmed PY - 2009/7/16/medline SP - 246 EP - 52 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 25 IS - 4 N2 - AIM: This study was performed to compare the serum levels of resistin and adiponectin in women with polycystic ovary syndrome (PCOS) and normal controls. MATERIALS AND METHODS: Seventy-six patients (36 obese, 40 non-obese) with PCOS and 42 healthy subjects were included in the study. Serum levels of resistin, adiponectin, follicle-stimulating hormone, luteinising hormone, dehydroepiandrosterone sulfate (DHEA-S), 17-hydroxy progesterone, free testosterone, androstenedione, glucose, insulin and lipid parameters were measured. Insulin resistance and carbohydrate metabolism were evaluated by using the homeostasis model (HOMA) and the area under the insulin curve (AUCI). RESULTS: Plasma resistin levels, HOMA-IR and AUCI were significantly higher and adiponectin level was lower in women with PCOS than those in healthy women. Plasma resistin levels were similar among obese and non-obese women with PCOS. No correlation was observed between resistin, body mass index (BMI), HOMA-IR, AUCI, insulin, lipid parameters and serum androgen levels. In obese PCOS patients, adiponectin levels were lower than in the lean PCOS patients. A negative correlation was observed among adiponectin, HOMA-IR, AUCI, BMI, testosterone, DHEAS, total-cholesterol, LDL-cholesterol and lipoprotein (a) levels. CONCLUSION: These results suggest that the serum adiponectin level may be involved in the pathogenesis of PCOS. But resistin levels were independently associated with insulin resistance and BMI in PCOS patients. Nevertheless, wider-scale trials are required to be performed on this subject. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/19408174/Serum_resistin_and_adiponectin_levels_in_women_with_polycystic_ovary_syndrome_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590802653833 DB - PRIME DP - Unbound Medicine ER -