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Characteristics of ATP-activated current in nodose ganglion neurons of rats.
Neurosci Lett 2009; 459(1):25-9NL

Abstract

The characteristics of ATP-activated currents (I(ATP)) in rat nodose ganglion (NG) neurons have not been fully clarified. Especially, the correlation between I(ATP) phenotype and P2X receptor subunit genotype in rat NG neuron is not clear. By whole-cell patch-clamp and single cell immunocytochemical techniques, we explored the characteristics of the I(ATP) phenotype and its correlation with P2X receptor subunits in acutely isolated NG neuron of rats. The results indicated that I(ATP) of NG neurons can be classified into four types: F type (fast type, 8.1%), I type (intermediate type, 14.8%), S type (slowing type, 37.0%) and vS type (very slowing type, 21.5%). The single immunocytochemical studies have demonstrated that F type cells express P2X1 and P2X3 subunits, I type cells P2X1, P2X3 and P2X4 subunits, S type cells P2X1, P2X2 and P2X3 subunits and vS type cells P2X2, P2X3 and P2X4 subunits. The results reveal that there are four types of I(ATP) in NG neurons, differential expression of distinct P2X subunits may underlie the I(ATP) phenotype.

Authors+Show Affiliations

Department of Neurology, The Affiliated Hospital of Guangdong Medical College, No. 57, People's Avenue South, Xiashan, Zhanjiang 524001, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19409446

Citation

Tan, Yan, et al. "Characteristics of ATP-activated Current in Nodose Ganglion Neurons of Rats." Neuroscience Letters, vol. 459, no. 1, 2009, pp. 25-9.
Tan Y, Zhao B, Zeng QC, et al. Characteristics of ATP-activated current in nodose ganglion neurons of rats. Neurosci Lett. 2009;459(1):25-9.
Tan, Y., Zhao, B., Zeng, Q. C., Shi, C. M., Zhao, F. B., & Li, Z. W. (2009). Characteristics of ATP-activated current in nodose ganglion neurons of rats. Neuroscience Letters, 459(1), pp. 25-9. doi:10.1016/j.neulet.2009.04.054.
Tan Y, et al. Characteristics of ATP-activated Current in Nodose Ganglion Neurons of Rats. Neurosci Lett. 2009 Jul 31;459(1):25-9. PubMed PMID: 19409446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of ATP-activated current in nodose ganglion neurons of rats. AU - Tan,Yan, AU - Zhao,Bin, AU - Zeng,Qing-Chun, AU - Shi,Chun-Mei, AU - Zhao,Feng-Bo, AU - Li,Zhi-Wang, Y1 - 2009/05/04/ PY - 2009/01/10/received PY - 2009/04/08/revised PY - 2009/04/14/accepted PY - 2009/5/5/entrez PY - 2009/5/5/pubmed PY - 2009/8/22/medline SP - 25 EP - 9 JF - Neuroscience letters JO - Neurosci. Lett. VL - 459 IS - 1 N2 - The characteristics of ATP-activated currents (I(ATP)) in rat nodose ganglion (NG) neurons have not been fully clarified. Especially, the correlation between I(ATP) phenotype and P2X receptor subunit genotype in rat NG neuron is not clear. By whole-cell patch-clamp and single cell immunocytochemical techniques, we explored the characteristics of the I(ATP) phenotype and its correlation with P2X receptor subunits in acutely isolated NG neuron of rats. The results indicated that I(ATP) of NG neurons can be classified into four types: F type (fast type, 8.1%), I type (intermediate type, 14.8%), S type (slowing type, 37.0%) and vS type (very slowing type, 21.5%). The single immunocytochemical studies have demonstrated that F type cells express P2X1 and P2X3 subunits, I type cells P2X1, P2X3 and P2X4 subunits, S type cells P2X1, P2X2 and P2X3 subunits and vS type cells P2X2, P2X3 and P2X4 subunits. The results reveal that there are four types of I(ATP) in NG neurons, differential expression of distinct P2X subunits may underlie the I(ATP) phenotype. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/19409446/Characteristics_of_ATP_activated_current_in_nodose_ganglion_neurons_of_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(09)00521-7 DB - PRIME DP - Unbound Medicine ER -