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Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins.
Fitoterapia. 2009 Sep; 80(6):339-44.F

Abstract

The present study concentrates on the evaluation of the anti-glycation effect of some bioactive substances present in yerba maté (Ilex paraguariensis): 5-caffeoylquinic acid, caffeic acid and a sapogenin (oleanolic acid). Bovine serum albumin and histones were incubated in the presence of methylglyoxal with or without the addition of 5-caffeoylquinic acid, caffeic acid and oleanolic acid. After the incubation period, advanced glycation end product (AGE) fluorescence spectra were performed and protein structural changes were evaluated by Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis. Chlorogenic acid, caffeic acid are the main substances responsible for the anti-glycation effect of maté tea.

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Authors+Show Affiliations

Gugliucci A
Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University-California, Mare Island Building H-83, 1310 Johnson Lane, Vallejo, CA 94592, USA. agugliuc@touro.edu
Bastos DH
No affiliation info available
Schulze J
No affiliation info available
Souza MF
No affiliation info available

MeSH

AnimalsAntioxidantsCaffeic AcidsCattleChlorogenic AcidElectrophoresis, Polyacrylamide GelFluorescenceGlycation End Products, AdvancedHistonesIlex paraguariensisOleanolic AcidPlant ExtractsPyruvaldehydeQuinic AcidSerum Albumin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19409454

Citation

Gugliucci, A, et al. "Caffeic and Chlorogenic Acids in Ilex Paraguariensis Extracts Are the Main Inhibitors of AGE Generation By Methylglyoxal in Model Proteins." Fitoterapia, vol. 80, no. 6, 2009, pp. 339-44.
Gugliucci A, Bastos DH, Schulze J, et al. Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins. Fitoterapia. 2009;80(6):339-44.
Gugliucci, A., Bastos, D. H., Schulze, J., & Souza, M. F. (2009). Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins. Fitoterapia, 80(6), 339-44. https://doi.org/10.1016/j.fitote.2009.04.007
Gugliucci A, et al. Caffeic and Chlorogenic Acids in Ilex Paraguariensis Extracts Are the Main Inhibitors of AGE Generation By Methylglyoxal in Model Proteins. Fitoterapia. 2009;80(6):339-44. PubMed PMID: 19409454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins. AU - Gugliucci,A, AU - Bastos,Deborah H Markowicz, AU - Schulze,John, AU - Souza,Marina F Ferreira, Y1 - 2009/05/04/ PY - 2008/12/18/received PY - 2009/04/20/revised PY - 2009/04/21/accepted PY - 2009/5/5/entrez PY - 2009/5/5/pubmed PY - 2009/11/6/medline SP - 339 EP - 44 JF - Fitoterapia JO - Fitoterapia VL - 80 IS - 6 N2 - The present study concentrates on the evaluation of the anti-glycation effect of some bioactive substances present in yerba maté (Ilex paraguariensis): 5-caffeoylquinic acid, caffeic acid and a sapogenin (oleanolic acid). Bovine serum albumin and histones were incubated in the presence of methylglyoxal with or without the addition of 5-caffeoylquinic acid, caffeic acid and oleanolic acid. After the incubation period, advanced glycation end product (AGE) fluorescence spectra were performed and protein structural changes were evaluated by Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis. Chlorogenic acid, caffeic acid are the main substances responsible for the anti-glycation effect of maté tea. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/19409454/Caffeic_and_chlorogenic_acids_in_Ilex_paraguariensis_extracts_are_the_main_inhibitors_of_AGE_generation_by_methylglyoxal_in_model_proteins_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(09)00078-1 DB - PRIME DP - Unbound Medicine ER -