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Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin.

Abstract

This experiment pertains to the protective role of naringenin against cadmium (Cd)-induced oxidative stress in the liver of rats. Cadmium is a major environmental pollutant and is known for its wide toxic manifestations. Naringenin is a naturally occurring citrus flavonone which has been reported to have a wide range of pharmacological properties. In the present investigation cadmium (5mg/kg) was administered orally for 4 weeks to induce hepatotoxicity. Liver damage induced by cadmium was clearly shown by the increased activities of serum hepatic marker enzymes namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT) and serum total bilirubin (TB) along with the increased level of lipid peroxidation indices (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) and protein carbonyl contents in liver. The toxic effect of cadmium was also indicated by significantly decreased levels of enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione S-transferase (GST)) and non-enzymatic antioxidants (reduced glutathione (GSH), vitamin C and vitamin E). Administration of naringenin at a dose of (50mg/kg) significantly reversed the activities of serum hepatic marker enzymes to their near-normal levels when compared to Cd-treated rats. In addition, naringenin significantly reduced lipid peroxidation and restored the levels of antioxidant defense in the liver. The histopathological studies in the liver of rats also showed that naringenin (50mg/kg) markedly reduced the toxicity of cadmium and preserved the normal histological architecture of the tissue. The present study suggested that naringenin may be beneficial in ameliorating the cadmium-induced oxidative damage in the liver of rats.

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  • Authors+Show Affiliations

    ,

    Department of Zoology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.

    Source

    MeSH

    Animals
    Antioxidants
    Biomarkers
    Cadmium
    Chemical and Drug Induced Liver Injury
    Flavanones
    Lipid Peroxidation
    Liver
    Male
    Oxidative Stress
    Rats
    Rats, Wistar

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19409769

    Citation

    Renugadevi, J, and S Milton Prabu. "Cadmium-induced Hepatotoxicity in Rats and the Protective Effect of Naringenin." Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, vol. 62, no. 2, 2010, pp. 171-81.
    Renugadevi J, Prabu SM. Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp Toxicol Pathol. 2010;62(2):171-81.
    Renugadevi, J., & Prabu, S. M. (2010). Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, 62(2), pp. 171-81. doi:10.1016/j.etp.2009.03.010.
    Renugadevi J, Prabu SM. Cadmium-induced Hepatotoxicity in Rats and the Protective Effect of Naringenin. Exp Toxicol Pathol. 2010;62(2):171-81. PubMed PMID: 19409769.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. AU - Renugadevi,J, AU - Prabu,S Milton, Y1 - 2009/05/05/ PY - 2009/03/02/received PY - 2009/03/13/revised PY - 2009/03/17/accepted PY - 2009/5/5/entrez PY - 2009/5/5/pubmed PY - 2010/5/12/medline SP - 171 EP - 81 JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie JO - Exp. Toxicol. Pathol. VL - 62 IS - 2 N2 - This experiment pertains to the protective role of naringenin against cadmium (Cd)-induced oxidative stress in the liver of rats. Cadmium is a major environmental pollutant and is known for its wide toxic manifestations. Naringenin is a naturally occurring citrus flavonone which has been reported to have a wide range of pharmacological properties. In the present investigation cadmium (5mg/kg) was administered orally for 4 weeks to induce hepatotoxicity. Liver damage induced by cadmium was clearly shown by the increased activities of serum hepatic marker enzymes namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT) and serum total bilirubin (TB) along with the increased level of lipid peroxidation indices (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) and protein carbonyl contents in liver. The toxic effect of cadmium was also indicated by significantly decreased levels of enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione S-transferase (GST)) and non-enzymatic antioxidants (reduced glutathione (GSH), vitamin C and vitamin E). Administration of naringenin at a dose of (50mg/kg) significantly reversed the activities of serum hepatic marker enzymes to their near-normal levels when compared to Cd-treated rats. In addition, naringenin significantly reduced lipid peroxidation and restored the levels of antioxidant defense in the liver. The histopathological studies in the liver of rats also showed that naringenin (50mg/kg) markedly reduced the toxicity of cadmium and preserved the normal histological architecture of the tissue. The present study suggested that naringenin may be beneficial in ameliorating the cadmium-induced oxidative damage in the liver of rats. SN - 1618-1433 UR - https://www.unboundmedicine.com/medline/citation/19409769/Cadmium_induced_hepatotoxicity_in_rats_and_the_protective_effect_of_naringenin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0940-2993(09)00145-6 DB - PRIME DP - Unbound Medicine ER -