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Cross-reactive antibodies in middle-aged and elderly volunteers after MF59-adjuvanted subunit trivalent influenza vaccine against B viruses of the B/Victoria or B/Yamagata lineages.
Vaccine. 2009 Jun 24; 27(31):4099-103.V

Abstract

This study evaluated whether MF59-adjuvanted subunit trivalent influenza vaccine for the 2003/04 winter season (A/Moscow/10/99, H3N2; A/New Caledonia/20/99, H1N1; B/Hong Kong/330/01) would confer protection against mismatched and frequently co-circulating variants of influenza B/Victoria- and B/Yamagata-like virus strains. Haemagglutination inhibiting (HI) antibodies were measured in middle-aged and elderly volunteers against the homologous B/Victoria-like vaccine strain (B/Hong Kong/330/01) and against mismatched B/Victoria-like (B/Malaysia/2506/04) and B/Yamagata-like (B/Singapore/379/99 and B/Shanghai/361/02) strains. Immunization induced significant increases in the amounts of HI antibodies against all influenza B strains under investigation. However, the responses against the heterologous B/Shanghai/361/02 virus did not reach the desirable values of seroprotection. An age-dependent decline of the responses was found for B/Victoria-like antigens, but not for B/Yamagata-like strains. Although further studies are needed, our data support the recommendation of including influenza B viruses of the B/Victoria and B/Yamagata lineages in the future influenza vaccine preparations.

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Authors+Show Affiliations

Camilloni B
Department of Medical and Surgical Specialties and Public Health, University of Perugia, Via del Giochetto, 06126 Perugia, Italy.
Neri M
No affiliation info available
Lepri E
No affiliation info available
Iorio AM
No affiliation info available

MeSH

Adjuvants, ImmunologicAdultAgedAged, 80 and overAntibodies, ViralCross ReactionsFemaleHemagglutination Inhibition TestsHuman ExperimentationHumansInfluenza B virusInfluenza VaccinesInfluenza, HumanMaleMiddle AgedPolysorbatesSqualeneVaccines, Subunit

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19410623

Citation

Camilloni, B, et al. "Cross-reactive Antibodies in Middle-aged and Elderly Volunteers After MF59-adjuvanted Subunit Trivalent Influenza Vaccine Against B Viruses of the B/Victoria or B/Yamagata Lineages." Vaccine, vol. 27, no. 31, 2009, pp. 4099-103.
Camilloni B, Neri M, Lepri E, et al. Cross-reactive antibodies in middle-aged and elderly volunteers after MF59-adjuvanted subunit trivalent influenza vaccine against B viruses of the B/Victoria or B/Yamagata lineages. Vaccine. 2009;27(31):4099-103.
Camilloni, B., Neri, M., Lepri, E., & Iorio, A. M. (2009). Cross-reactive antibodies in middle-aged and elderly volunteers after MF59-adjuvanted subunit trivalent influenza vaccine against B viruses of the B/Victoria or B/Yamagata lineages. Vaccine, 27(31), 4099-103. https://doi.org/10.1016/j.vaccine.2009.04.078
Camilloni B, et al. Cross-reactive Antibodies in Middle-aged and Elderly Volunteers After MF59-adjuvanted Subunit Trivalent Influenza Vaccine Against B Viruses of the B/Victoria or B/Yamagata Lineages. Vaccine. 2009 Jun 24;27(31):4099-103. PubMed PMID: 19410623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cross-reactive antibodies in middle-aged and elderly volunteers after MF59-adjuvanted subunit trivalent influenza vaccine against B viruses of the B/Victoria or B/Yamagata lineages. AU - Camilloni,B, AU - Neri,M, AU - Lepri,E, AU - Iorio,A M, Y1 - 2009/05/14/ PY - 2008/12/11/received PY - 2009/04/07/revised PY - 2009/04/25/accepted PY - 2009/5/5/entrez PY - 2009/5/5/pubmed PY - 2009/9/1/medline SP - 4099 EP - 103 JF - Vaccine JO - Vaccine VL - 27 IS - 31 N2 - This study evaluated whether MF59-adjuvanted subunit trivalent influenza vaccine for the 2003/04 winter season (A/Moscow/10/99, H3N2; A/New Caledonia/20/99, H1N1; B/Hong Kong/330/01) would confer protection against mismatched and frequently co-circulating variants of influenza B/Victoria- and B/Yamagata-like virus strains. Haemagglutination inhibiting (HI) antibodies were measured in middle-aged and elderly volunteers against the homologous B/Victoria-like vaccine strain (B/Hong Kong/330/01) and against mismatched B/Victoria-like (B/Malaysia/2506/04) and B/Yamagata-like (B/Singapore/379/99 and B/Shanghai/361/02) strains. Immunization induced significant increases in the amounts of HI antibodies against all influenza B strains under investigation. However, the responses against the heterologous B/Shanghai/361/02 virus did not reach the desirable values of seroprotection. An age-dependent decline of the responses was found for B/Victoria-like antigens, but not for B/Yamagata-like strains. Although further studies are needed, our data support the recommendation of including influenza B viruses of the B/Victoria and B/Yamagata lineages in the future influenza vaccine preparations. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/19410623/Cross_reactive_antibodies_in_middle_aged_and_elderly_volunteers_after_MF59_adjuvanted_subunit_trivalent_influenza_vaccine_against_B_viruses_of_the_B/Victoria_or_B/Yamagata_lineages_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(09)00644-6 DB - PRIME DP - Unbound Medicine ER -