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High-speed ultrahigh resolution optical coherence tomography before and after ranibizumab for age-related macular degeneration.
Ophthalmology. 2009 May; 116(5):956-63.O

Abstract

OBJECTIVE

To evaluate intraretinal anatomy in patients with exudative age-related macular degeneration (AMD) using high-speed ultrahigh resolution optical coherence tomography (hsUHR-OCT) before and 1 month after intravitreal injection of ranibizumab.

DESIGN

Retrospective case series.

PARTICIPANTS

Twelve eyes of 12 patients.

METHODS

A broad bandwidth superluminescent diode laser light source and spectral/Fourier domain signal detection were used to create a prototype hsUHR-OCT instrument with 3.5 mum axial image resolution and approximately 25,000 lines/second acquisition speed. Twelve eyes of 12 patients with exudative AMD were imaged with hsUHR-OCT before and 1 month after intravitreal ranibizumab injection. High pixel density and raster-scanned 3-dimensional (3D) OCT data sets were generated. Three-dimensional imaging software was used to calculate subretinal/retinal pigment epithelium fluid volume and volume of the fibrovascular lesion.

MAIN OUTCOME MEASURES

Qualitative and quantitative analysis of hsUHR-OCT images and 3D data sets.

RESULTS

All eyes had some degree of normalization of macular contour after intravitreal ranibizumab. The inner/outer photoreceptor segment junction visualized on hsUHR-OCT was discontinuous, overlying the fibrovascular lesion in all 12 of 12 eyes both before and after treatment; 9 of 12 eyes had focal areas of thinning of the outer nuclear layer, which remained after treatment. Volumetric measurements were possible in 8 of 12 eyes with 3D-rendering software. Fibrovascular lesion volume did not change significantly after treatment.

CONCLUSIONS

hsUHR-OCT is capable of unprecedented imaging speed and resolution, making it a valuable instrument in measuring in vivo intraretinal pathology. All 12 eyes had some normalization of macular contour. Fibrovascular lesion volume did not change significantly 1 month after treatment, suggesting that ranibizumab does not cause much initial regression of preexisting neovascular tissue. Photoreceptor abnormalities remained in all patients after treatment of wet AMD, suggesting that although ranibizumab improves overall retinal architecture, some photoreceptor damage may be irreversible.

FINANCIAL DISCLOSURE(S)

Proprietary or commercial disclosure may be found after the references.

Authors+Show Affiliations

Tufts Medical Center, Tufts University, 800 Washington Street, Boston, MA 02111,USA. AJWitkin@Gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19410953

Citation

Witkin, Andre J., et al. "High-speed Ultrahigh Resolution Optical Coherence Tomography Before and After Ranibizumab for Age-related Macular Degeneration." Ophthalmology, vol. 116, no. 5, 2009, pp. 956-63.
Witkin AJ, Vuong LN, Srinivasan VJ, et al. High-speed ultrahigh resolution optical coherence tomography before and after ranibizumab for age-related macular degeneration. Ophthalmology. 2009;116(5):956-63.
Witkin, A. J., Vuong, L. N., Srinivasan, V. J., Gorczynska, I., Reichel, E., Baumal, C. R., Rogers, A. H., Schuman, J. S., Fujimoto, J. G., & Duker, J. S. (2009). High-speed ultrahigh resolution optical coherence tomography before and after ranibizumab for age-related macular degeneration. Ophthalmology, 116(5), 956-63. https://doi.org/10.1016/j.ophtha.2008.12.018
Witkin AJ, et al. High-speed Ultrahigh Resolution Optical Coherence Tomography Before and After Ranibizumab for Age-related Macular Degeneration. Ophthalmology. 2009;116(5):956-63. PubMed PMID: 19410953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-speed ultrahigh resolution optical coherence tomography before and after ranibizumab for age-related macular degeneration. AU - Witkin,Andre J, AU - Vuong,Laurel N, AU - Srinivasan,Vivek J, AU - Gorczynska,Iwona, AU - Reichel,Elias, AU - Baumal,Caroline R, AU - Rogers,Adam H, AU - Schuman,Joel S, AU - Fujimoto,James G, AU - Duker,Jay S, PY - 2008/07/12/received PY - 2008/09/30/revised PY - 2008/12/04/accepted PY - 2009/5/5/entrez PY - 2009/5/5/pubmed PY - 2009/5/15/medline SP - 956 EP - 63 JF - Ophthalmology JO - Ophthalmology VL - 116 IS - 5 N2 - OBJECTIVE: To evaluate intraretinal anatomy in patients with exudative age-related macular degeneration (AMD) using high-speed ultrahigh resolution optical coherence tomography (hsUHR-OCT) before and 1 month after intravitreal injection of ranibizumab. DESIGN: Retrospective case series. PARTICIPANTS: Twelve eyes of 12 patients. METHODS: A broad bandwidth superluminescent diode laser light source and spectral/Fourier domain signal detection were used to create a prototype hsUHR-OCT instrument with 3.5 mum axial image resolution and approximately 25,000 lines/second acquisition speed. Twelve eyes of 12 patients with exudative AMD were imaged with hsUHR-OCT before and 1 month after intravitreal ranibizumab injection. High pixel density and raster-scanned 3-dimensional (3D) OCT data sets were generated. Three-dimensional imaging software was used to calculate subretinal/retinal pigment epithelium fluid volume and volume of the fibrovascular lesion. MAIN OUTCOME MEASURES: Qualitative and quantitative analysis of hsUHR-OCT images and 3D data sets. RESULTS: All eyes had some degree of normalization of macular contour after intravitreal ranibizumab. The inner/outer photoreceptor segment junction visualized on hsUHR-OCT was discontinuous, overlying the fibrovascular lesion in all 12 of 12 eyes both before and after treatment; 9 of 12 eyes had focal areas of thinning of the outer nuclear layer, which remained after treatment. Volumetric measurements were possible in 8 of 12 eyes with 3D-rendering software. Fibrovascular lesion volume did not change significantly after treatment. CONCLUSIONS: hsUHR-OCT is capable of unprecedented imaging speed and resolution, making it a valuable instrument in measuring in vivo intraretinal pathology. All 12 eyes had some normalization of macular contour. Fibrovascular lesion volume did not change significantly 1 month after treatment, suggesting that ranibizumab does not cause much initial regression of preexisting neovascular tissue. Photoreceptor abnormalities remained in all patients after treatment of wet AMD, suggesting that although ranibizumab improves overall retinal architecture, some photoreceptor damage may be irreversible. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/19410953/High_speed_ultrahigh_resolution_optical_coherence_tomography_before_and_after_ranibizumab_for_age_related_macular_degeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(08)01273-6 DB - PRIME DP - Unbound Medicine ER -