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Variability in measurements of blood glucose response to foods in human subjects is not reduced after a standard breakfast.
Nutr Res. 2009 Apr; 29(4):238-43.NR

Abstract

Measurements of blood glucose response to food are highly variable. We determined whether within-individual variability in data for blood glucose responses were reduced if individuals consumed a standard meal 2 hours before testing and investigated the effect of serving size. Blood glucose responses to muesli and macaroni cheese were determined in 13 individuals by taking 2 fasting capillary blood samples. Food was then consumed, and capillary blood samples were taken every 15 minutes for the first hour and every 30 minutes for the second hour. The incremental area under the blood glucose response curve was determined, and glycemic glucose equivalents (GGEs) were calculated. The GGE values were not significantly different whether the muesli and macaroni cheese were fed fasting or after a standard breakfast (29.2 vs 34.5 g for muesli and 11.0 vs 14.6 g for macaroni cheese). Within-individual coefficients of variation were not significantly different whether the food was consumed fasting or after a standard breakfast (24.9% and 32.5% for muesli and 38.1% and 59.4% for macaroni cheese). Differences in GGE between measured and estimated half serving size for macaroni cheese were 0.8 g (P = .6) and for muesli, 3 g (P = .2); for the double serving size for macaroni cheese, 1.7 g (P = .7); and for muesli, 6.7 g (P = .06). The GGE values for foods and variability in blood glucose response within individuals were not significantly different whether individuals fasted or consumed a standard breakfast before testing. However, blood glucose levels tended to differ significantly after consumption of the double serving size of muesli compared with other serving sizes.

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Authors+Show Affiliations

Wallace AJ
New Zealand Institute for Plant and Food Research Limited, Private Bag 4704, Christchurch 8140, New Zealand. wallaceaj@crop.cri.nz
Eady SL
No affiliation info available
Willis JA
No affiliation info available
Scott RS
No affiliation info available
Monro JA
No affiliation info available
Frampton CM
No affiliation info available

MeSH

AdultArea Under CurveBlood GlucoseCheeseDietary CarbohydratesDietary FatsEdible GrainFoodGlycemic IndexHumansMiddle AgedReproducibility of ResultsTime Factors

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19410974

Citation

Wallace, Alison J., et al. "Variability in Measurements of Blood Glucose Response to Foods in Human Subjects Is Not Reduced After a Standard Breakfast." Nutrition Research (New York, N.Y.), vol. 29, no. 4, 2009, pp. 238-43.
Wallace AJ, Eady SL, Willis JA, et al. Variability in measurements of blood glucose response to foods in human subjects is not reduced after a standard breakfast. Nutr Res. 2009;29(4):238-43.
Wallace, A. J., Eady, S. L., Willis, J. A., Scott, R. S., Monro, J. A., & Frampton, C. M. (2009). Variability in measurements of blood glucose response to foods in human subjects is not reduced after a standard breakfast. Nutrition Research (New York, N.Y.), 29(4), 238-43. https://doi.org/10.1016/j.nutres.2009.03.003
Wallace AJ, et al. Variability in Measurements of Blood Glucose Response to Foods in Human Subjects Is Not Reduced After a Standard Breakfast. Nutr Res. 2009;29(4):238-43. PubMed PMID: 19410974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variability in measurements of blood glucose response to foods in human subjects is not reduced after a standard breakfast. AU - Wallace,Alison J, AU - Eady,Sarah L, AU - Willis,Jinny A, AU - Scott,Russell S, AU - Monro,John A, AU - Frampton,Chris M, PY - 2009/01/20/received PY - 2009/03/02/revised PY - 2009/03/05/accepted PY - 2009/5/5/entrez PY - 2009/5/5/pubmed PY - 2009/7/8/medline SP - 238 EP - 43 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 29 IS - 4 N2 - Measurements of blood glucose response to food are highly variable. We determined whether within-individual variability in data for blood glucose responses were reduced if individuals consumed a standard meal 2 hours before testing and investigated the effect of serving size. Blood glucose responses to muesli and macaroni cheese were determined in 13 individuals by taking 2 fasting capillary blood samples. Food was then consumed, and capillary blood samples were taken every 15 minutes for the first hour and every 30 minutes for the second hour. The incremental area under the blood glucose response curve was determined, and glycemic glucose equivalents (GGEs) were calculated. The GGE values were not significantly different whether the muesli and macaroni cheese were fed fasting or after a standard breakfast (29.2 vs 34.5 g for muesli and 11.0 vs 14.6 g for macaroni cheese). Within-individual coefficients of variation were not significantly different whether the food was consumed fasting or after a standard breakfast (24.9% and 32.5% for muesli and 38.1% and 59.4% for macaroni cheese). Differences in GGE between measured and estimated half serving size for macaroni cheese were 0.8 g (P = .6) and for muesli, 3 g (P = .2); for the double serving size for macaroni cheese, 1.7 g (P = .7); and for muesli, 6.7 g (P = .06). The GGE values for foods and variability in blood glucose response within individuals were not significantly different whether individuals fasted or consumed a standard breakfast before testing. However, blood glucose levels tended to differ significantly after consumption of the double serving size of muesli compared with other serving sizes. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/19410974/Variability_in_measurements_of_blood_glucose_response_to_foods_in_human_subjects_is_not_reduced_after_a_standard_breakfast_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(09)00039-6 DB - PRIME DP - Unbound Medicine ER -