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Carbohydrate restriction (with or without additional dietary cholesterol provided by eggs) reduces insulin resistance and plasma leptin without modifying appetite hormones in adult men.
Nutr Res. 2009 Apr; 29(4):262-8.NR

Abstract

Carbohydrate-restricted diets (CRDs) have been shown to reduce body weight, whereas whole egg intake has been associated with increased satiety. The purpose of this study was to evaluate the effects of additional dietary cholesterol and protein provided by whole eggs while following a CRD on insulin resistance and appetite hormones. Using a randomized blind parallel design, subjects were allocated to an egg (640 mg/d additional dietary cholesterol) or placebo (0 mg/d additional dietary cholesterol) group for 12 weeks while following a CRD. There were significant reductions in fasting insulin (P < .025) and fasting leptin concentrations (P < .01) for both groups, which were correlated with the reductions in body weight and body fat (P < .05 and P < .01, respectively). Both groups reduced insulin resistance as measured by the homeostatic model assessment of insulin resistance (P < .025). There was a significant decrease in serum glucose levels observed after the intervention. We did not observe the expected increases in plasma ghrelin levels associated with weight loss, suggesting a mechanism by which subjects do not increase appetite with CRD. To confirm these results, the subjective measures of satiety using visual analog scale showed that both groups felt more "full" (P < .05), "satisfied" (P < .001), and "wanted to eat less" (P < .001) after the intervention. These results indicate that inclusion of eggs in the diet (additional dietary cholesterol) did not modify the multiple beneficial effects of CRD on insulin resistance and appetite hormones.

Authors+Show Affiliations

Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19410978

Citation

Ratliff, Joseph, et al. "Carbohydrate Restriction (with or Without Additional Dietary Cholesterol Provided By Eggs) Reduces Insulin Resistance and Plasma Leptin Without Modifying Appetite Hormones in Adult Men." Nutrition Research (New York, N.Y.), vol. 29, no. 4, 2009, pp. 262-8.
Ratliff J, Mutungi G, Puglisi MJ, et al. Carbohydrate restriction (with or without additional dietary cholesterol provided by eggs) reduces insulin resistance and plasma leptin without modifying appetite hormones in adult men. Nutr Res. 2009;29(4):262-8.
Ratliff, J., Mutungi, G., Puglisi, M. J., Volek, J. S., & Fernandez, M. L. (2009). Carbohydrate restriction (with or without additional dietary cholesterol provided by eggs) reduces insulin resistance and plasma leptin without modifying appetite hormones in adult men. Nutrition Research (New York, N.Y.), 29(4), 262-8. https://doi.org/10.1016/j.nutres.2009.03.007
Ratliff J, et al. Carbohydrate Restriction (with or Without Additional Dietary Cholesterol Provided By Eggs) Reduces Insulin Resistance and Plasma Leptin Without Modifying Appetite Hormones in Adult Men. Nutr Res. 2009;29(4):262-8. PubMed PMID: 19410978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbohydrate restriction (with or without additional dietary cholesterol provided by eggs) reduces insulin resistance and plasma leptin without modifying appetite hormones in adult men. AU - Ratliff,Joseph, AU - Mutungi,Gisella, AU - Puglisi,Michael J, AU - Volek,Jeff S, AU - Fernandez,Maria Luz, PY - 2008/12/29/received PY - 2009/03/15/revised PY - 2009/03/23/accepted PY - 2009/5/5/entrez PY - 2009/5/5/pubmed PY - 2009/7/8/medline SP - 262 EP - 8 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 29 IS - 4 N2 - Carbohydrate-restricted diets (CRDs) have been shown to reduce body weight, whereas whole egg intake has been associated with increased satiety. The purpose of this study was to evaluate the effects of additional dietary cholesterol and protein provided by whole eggs while following a CRD on insulin resistance and appetite hormones. Using a randomized blind parallel design, subjects were allocated to an egg (640 mg/d additional dietary cholesterol) or placebo (0 mg/d additional dietary cholesterol) group for 12 weeks while following a CRD. There were significant reductions in fasting insulin (P < .025) and fasting leptin concentrations (P < .01) for both groups, which were correlated with the reductions in body weight and body fat (P < .05 and P < .01, respectively). Both groups reduced insulin resistance as measured by the homeostatic model assessment of insulin resistance (P < .025). There was a significant decrease in serum glucose levels observed after the intervention. We did not observe the expected increases in plasma ghrelin levels associated with weight loss, suggesting a mechanism by which subjects do not increase appetite with CRD. To confirm these results, the subjective measures of satiety using visual analog scale showed that both groups felt more "full" (P < .05), "satisfied" (P < .001), and "wanted to eat less" (P < .001) after the intervention. These results indicate that inclusion of eggs in the diet (additional dietary cholesterol) did not modify the multiple beneficial effects of CRD on insulin resistance and appetite hormones. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/19410978/Carbohydrate_restriction__with_or_without_additional_dietary_cholesterol_provided_by_eggs__reduces_insulin_resistance_and_plasma_leptin_without_modifying_appetite_hormones_in_adult_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(09)00052-9 DB - PRIME DP - Unbound Medicine ER -