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Trends in nonalcoholic fatty liver disease-related hospitalizations in US children, adolescents, and young adults.
J Pediatr Gastroenterol Nutr. 2009 May; 48(5):597-603.JP

Abstract

OBJECTIVE

To investigate temporal trends of nonalcoholic fatty liver disease (NAFLD) and obesity among hospitalized US children, adolescents, and young adults over the past 2 decades and to examine potential sex disparities in NAFLD hospitalizations.

METHODS

Hospitalization discharges with NAFLD or obesity were identified among children and young adults (6-25 years, weighted n = 91,687,413) from the 1986 to 2006 National Hospital Discharge Survey data. Age- and sex-specific rates and trends in hospitalizations with NAFLD and obesity were estimated. Rates were standardized to age distribution of the 2000 US Census population. Sex disparities were examined for the most recent period 2004 to 2006 (weighted n = 12,969,532).

RESULTS

Between 1986 to 1988 and 2004 to 2006, hospitalizations with NAFLD diagnosis increased from 0.9 to 4.3/100,000 population (P < 0.001). During the same time, hospitalizations with a diagnosis of obesity increased from 35.5 to 114.7/100,000 population (P < 0.001). During 2004 to 2006, hospitalization rates with a diagnosis of NAFLD were higher among females than among males (5.9 vs 2.7/100,000 population, P < 0.001), as were hospitalizations with a diagnosis of obesity (140.8 vs 61.5/100,000 population, P < 0.001). Obesity and diabetes were reported in 43.3% and 31.9%, respectively, of discharges with NAFLD.

CONCLUSION

The prevalence of NAFLD among young hospitalized patients increased in the past 2 decades, paralleling obesity-related hospitalizations. This could be a consequence of the obesity epidemic or of increased screening for liver disease.

Authors+Show Affiliations

Department of Research and Evaluation, Kaiser Permanente Southern California, 100 Los Robles, 2nd Floor, Pasadena, CA 91101, USA. Corinna.Koebnick@kp.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19412009

Citation

Koebnick, Corinna, et al. "Trends in Nonalcoholic Fatty Liver Disease-related Hospitalizations in US Children, Adolescents, and Young Adults." Journal of Pediatric Gastroenterology and Nutrition, vol. 48, no. 5, 2009, pp. 597-603.
Koebnick C, Getahun D, Reynolds K, et al. Trends in nonalcoholic fatty liver disease-related hospitalizations in US children, adolescents, and young adults. J Pediatr Gastroenterol Nutr. 2009;48(5):597-603.
Koebnick, C., Getahun, D., Reynolds, K., Coleman, K. J., Porter, A. H., Lawrence, J. M., Punyanitya, M., Quinn, V. P., & Jacobsen, S. J. (2009). Trends in nonalcoholic fatty liver disease-related hospitalizations in US children, adolescents, and young adults. Journal of Pediatric Gastroenterology and Nutrition, 48(5), 597-603. https://doi.org/10.1097/MPG.0b013e318192d224
Koebnick C, et al. Trends in Nonalcoholic Fatty Liver Disease-related Hospitalizations in US Children, Adolescents, and Young Adults. J Pediatr Gastroenterol Nutr. 2009;48(5):597-603. PubMed PMID: 19412009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trends in nonalcoholic fatty liver disease-related hospitalizations in US children, adolescents, and young adults. AU - Koebnick,Corinna, AU - Getahun,Darios, AU - Reynolds,Kristi, AU - Coleman,Karen J, AU - Porter,Amy H, AU - Lawrence,Jean M, AU - Punyanitya,Mark, AU - Quinn,Virginia P, AU - Jacobsen,Steven J, PY - 2009/5/5/entrez PY - 2009/5/5/pubmed PY - 2009/7/25/medline SP - 597 EP - 603 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 48 IS - 5 N2 - OBJECTIVE: To investigate temporal trends of nonalcoholic fatty liver disease (NAFLD) and obesity among hospitalized US children, adolescents, and young adults over the past 2 decades and to examine potential sex disparities in NAFLD hospitalizations. METHODS: Hospitalization discharges with NAFLD or obesity were identified among children and young adults (6-25 years, weighted n = 91,687,413) from the 1986 to 2006 National Hospital Discharge Survey data. Age- and sex-specific rates and trends in hospitalizations with NAFLD and obesity were estimated. Rates were standardized to age distribution of the 2000 US Census population. Sex disparities were examined for the most recent period 2004 to 2006 (weighted n = 12,969,532). RESULTS: Between 1986 to 1988 and 2004 to 2006, hospitalizations with NAFLD diagnosis increased from 0.9 to 4.3/100,000 population (P < 0.001). During the same time, hospitalizations with a diagnosis of obesity increased from 35.5 to 114.7/100,000 population (P < 0.001). During 2004 to 2006, hospitalization rates with a diagnosis of NAFLD were higher among females than among males (5.9 vs 2.7/100,000 population, P < 0.001), as were hospitalizations with a diagnosis of obesity (140.8 vs 61.5/100,000 population, P < 0.001). Obesity and diabetes were reported in 43.3% and 31.9%, respectively, of discharges with NAFLD. CONCLUSION: The prevalence of NAFLD among young hospitalized patients increased in the past 2 decades, paralleling obesity-related hospitalizations. This could be a consequence of the obesity epidemic or of increased screening for liver disease. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/19412009/Trends_in_nonalcoholic_fatty_liver_disease_related_hospitalizations_in_US_children_adolescents_and_young_adults_ L2 - https://doi.org/10.1097/MPG.0b013e318192d224 DB - PRIME DP - Unbound Medicine ER -