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What works best for whom? An exploratory, subgroup analysis in a randomized, controlled trial on the effectiveness of a workplace intervention in low back pain patients on return to work.
Spine (Phila Pa 1976). 2009 May 20; 34(12):1243-9.S

Abstract

STUDY DESIGN

Exploratory subgroup analysis in a randomized controlled trial (RCT).

OBJECTIVE

To detect possible moderators in the effectiveness of a workplace intervention in a population of workers with sick leave due to sub acute nonspecific low back pain.

SUMMARY OF BACKGROUND DATA

In a recently published RCT, a workplace intervention was effective on return to work, compared to usual care. Examining the heterogeneity of effect sizes within the population in this RCT (n = 196) can lead to information on the effectiveness of the intervention in subgroups of patients.

METHODS

A subgroup analysis was performed by adding interaction terms to the statistical model. Before analysis the following possible moderators for treatment were identified: age, gender, pain, functional status, heavy work, and sick leave in the previous 12 months. Cox regression analyses were performed and survival curves were plotted.

RESULTS

The interaction (P = 0.02) between age (dichotomized at the median value) and the workplace intervention indicates a modifying effect. The workplace intervention is more effective for workers > or =44 years (HR, 95% CI = 2.5, [1.6, 4.1] vs. 1.2 [0.8, 1.8] for workers <44 years old). The interaction between sick leave in the previous 12 months and the workplace intervention is significant (P = 0.02). The intervention is more effective for workers with previous sick leave (HR, 95% CI = 2.8 [1.7, 4.9] vs. 1.3 [0.8, 2.0]). A modifying effect of gender, heavy work, and pain score and functional status on the effectiveness of this intervention was not found.

CONCLUSION

The findings from these exploratory analyses should be tested in future RCTs. This workplace intervention seems very suitable for return to work of older workers and workers with previous sick leave. Gender, perceived heavy work, and baseline scores in pain and functional status should not be a basis for assignment to this intervention.

Authors+Show Affiliations

Institute for Work and Health, Toronto, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19412140

Citation

Steenstra, Ivan A., et al. "What Works Best for Whom? an Exploratory, Subgroup Analysis in a Randomized, Controlled Trial On the Effectiveness of a Workplace Intervention in Low Back Pain Patients On Return to Work." Spine, vol. 34, no. 12, 2009, pp. 1243-9.
Steenstra IA, Knol DL, Bongers PM, et al. What works best for whom? An exploratory, subgroup analysis in a randomized, controlled trial on the effectiveness of a workplace intervention in low back pain patients on return to work. Spine (Phila Pa 1976). 2009;34(12):1243-9.
Steenstra, I. A., Knol, D. L., Bongers, P. M., Anema, J. R., van Mechelen, W., & de Vet, H. C. (2009). What works best for whom? An exploratory, subgroup analysis in a randomized, controlled trial on the effectiveness of a workplace intervention in low back pain patients on return to work. Spine, 34(12), 1243-9. https://doi.org/10.1097/BRS.0b013e3181a09631
Steenstra IA, et al. What Works Best for Whom? an Exploratory, Subgroup Analysis in a Randomized, Controlled Trial On the Effectiveness of a Workplace Intervention in Low Back Pain Patients On Return to Work. Spine (Phila Pa 1976). 2009 May 20;34(12):1243-9. PubMed PMID: 19412140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What works best for whom? An exploratory, subgroup analysis in a randomized, controlled trial on the effectiveness of a workplace intervention in low back pain patients on return to work. AU - Steenstra,Ivan A, AU - Knol,Dirk L, AU - Bongers,Paulien M, AU - Anema,Johannes R, AU - van Mechelen,Willem, AU - de Vet,Henrica C W, PY - 2009/5/5/entrez PY - 2009/5/5/pubmed PY - 2009/8/26/medline SP - 1243 EP - 9 JF - Spine JO - Spine (Phila Pa 1976) VL - 34 IS - 12 N2 - STUDY DESIGN: Exploratory subgroup analysis in a randomized controlled trial (RCT). OBJECTIVE: To detect possible moderators in the effectiveness of a workplace intervention in a population of workers with sick leave due to sub acute nonspecific low back pain. SUMMARY OF BACKGROUND DATA: In a recently published RCT, a workplace intervention was effective on return to work, compared to usual care. Examining the heterogeneity of effect sizes within the population in this RCT (n = 196) can lead to information on the effectiveness of the intervention in subgroups of patients. METHODS: A subgroup analysis was performed by adding interaction terms to the statistical model. Before analysis the following possible moderators for treatment were identified: age, gender, pain, functional status, heavy work, and sick leave in the previous 12 months. Cox regression analyses were performed and survival curves were plotted. RESULTS: The interaction (P = 0.02) between age (dichotomized at the median value) and the workplace intervention indicates a modifying effect. The workplace intervention is more effective for workers > or =44 years (HR, 95% CI = 2.5, [1.6, 4.1] vs. 1.2 [0.8, 1.8] for workers <44 years old). The interaction between sick leave in the previous 12 months and the workplace intervention is significant (P = 0.02). The intervention is more effective for workers with previous sick leave (HR, 95% CI = 2.8 [1.7, 4.9] vs. 1.3 [0.8, 2.0]). A modifying effect of gender, heavy work, and pain score and functional status on the effectiveness of this intervention was not found. CONCLUSION: The findings from these exploratory analyses should be tested in future RCTs. This workplace intervention seems very suitable for return to work of older workers and workers with previous sick leave. Gender, perceived heavy work, and baseline scores in pain and functional status should not be a basis for assignment to this intervention. SN - 1528-1159 UR - https://www.unboundmedicine.com/medline/citation/19412140/What_works_best_for_whom_An_exploratory_subgroup_analysis_in_a_randomized_controlled_trial_on_the_effectiveness_of_a_workplace_intervention_in_low_back_pain_patients_on_return_to_work_ L2 - https://doi.org/10.1097/BRS.0b013e3181a09631 DB - PRIME DP - Unbound Medicine ER -