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Effects of the endocannabinoid transport inhibitors AM404 and UCM707 on diabetic neuropathy in rats.
Clin Exp Pharmacol Physiol. 2009 Nov; 36(11):1127-31.CE

Abstract

1. Diabetic rats display increased pain responses following injection of formalin into the paw, suggesting the presence of hyperalgesia. In the present study, we investigated the efficacy of the systemic administration of the endocannabinoid transport inhibitors UCM707 and AM404 (1, 10 and 50 mg/kg, i.p.) on hyperalgesia during the formalin test in streptozocin (STZ)-induced diabetic rats. 2. Nociceptive testing was performed in male adult Wistar rats 4 weeks after the onset of hyperglycaemia. At the end of the experiment, all rats were weighed and then underwent plasma glucose measurements. 3. Diabetes caused significant hyperalgesia during both phases of the formalin test. At 10 and 50 mg/kg, both UCM707 and AM404 reversed chemical hyperalgesia in diabetic rats. UCM707 (10 and 50 mg/kg) caused less intensive nociceptive behaviour during both phases of the test, whereas AM404 (10 and 50 mg/kg) only affected pain scores during Phase 1 of the formalin test. At 1 mg, neither drug had any effect on pain behaviour in control and diabetic groups compared with their respective controls. Neither UCM707 nor AM404 had any effect on bodyweight or plasma glucose levels of treated compared with non-treated rats at any of the doses tested. 4. The results of the present study indicate that systemic administration of UCM707 and AM404 is effective in ameliorating chemical hyperalgesia in STZ-diabetic rats. Thus, endocannabinoid transport inhibitors may have potential in the treatment of painful diabetic neuropathy.

Authors+Show Affiliations

Department of Biology, School of Basic Sciences, Bu-Ali Sina University, Hamadan, Iran. p.hasanein@basu.ac.irNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19413593

Citation

Hasanein, Parisa, and Nepton Soltani. "Effects of the Endocannabinoid Transport Inhibitors AM404 and UCM707 On Diabetic Neuropathy in Rats." Clinical and Experimental Pharmacology & Physiology, vol. 36, no. 11, 2009, pp. 1127-31.
Hasanein P, Soltani N. Effects of the endocannabinoid transport inhibitors AM404 and UCM707 on diabetic neuropathy in rats. Clin Exp Pharmacol Physiol. 2009;36(11):1127-31.
Hasanein, P., & Soltani, N. (2009). Effects of the endocannabinoid transport inhibitors AM404 and UCM707 on diabetic neuropathy in rats. Clinical and Experimental Pharmacology & Physiology, 36(11), 1127-31. https://doi.org/10.1111/j.1440-1681.2009.05197.x
Hasanein P, Soltani N. Effects of the Endocannabinoid Transport Inhibitors AM404 and UCM707 On Diabetic Neuropathy in Rats. Clin Exp Pharmacol Physiol. 2009;36(11):1127-31. PubMed PMID: 19413593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the endocannabinoid transport inhibitors AM404 and UCM707 on diabetic neuropathy in rats. AU - Hasanein,Parisa, AU - Soltani,Nepton, Y1 - 2009/04/27/ PY - 2009/5/6/entrez PY - 2009/5/6/pubmed PY - 2010/2/19/medline SP - 1127 EP - 31 JF - Clinical and experimental pharmacology & physiology JO - Clin Exp Pharmacol Physiol VL - 36 IS - 11 N2 - 1. Diabetic rats display increased pain responses following injection of formalin into the paw, suggesting the presence of hyperalgesia. In the present study, we investigated the efficacy of the systemic administration of the endocannabinoid transport inhibitors UCM707 and AM404 (1, 10 and 50 mg/kg, i.p.) on hyperalgesia during the formalin test in streptozocin (STZ)-induced diabetic rats. 2. Nociceptive testing was performed in male adult Wistar rats 4 weeks after the onset of hyperglycaemia. At the end of the experiment, all rats were weighed and then underwent plasma glucose measurements. 3. Diabetes caused significant hyperalgesia during both phases of the formalin test. At 10 and 50 mg/kg, both UCM707 and AM404 reversed chemical hyperalgesia in diabetic rats. UCM707 (10 and 50 mg/kg) caused less intensive nociceptive behaviour during both phases of the test, whereas AM404 (10 and 50 mg/kg) only affected pain scores during Phase 1 of the formalin test. At 1 mg, neither drug had any effect on pain behaviour in control and diabetic groups compared with their respective controls. Neither UCM707 nor AM404 had any effect on bodyweight or plasma glucose levels of treated compared with non-treated rats at any of the doses tested. 4. The results of the present study indicate that systemic administration of UCM707 and AM404 is effective in ameliorating chemical hyperalgesia in STZ-diabetic rats. Thus, endocannabinoid transport inhibitors may have potential in the treatment of painful diabetic neuropathy. SN - 1440-1681 UR - https://www.unboundmedicine.com/medline/citation/19413593/Effects_of_the_endocannabinoid_transport_inhibitors_AM404_and_UCM707_on_diabetic_neuropathy_in_rats_ L2 - https://doi.org/10.1111/j.1440-1681.2009.05197.x DB - PRIME DP - Unbound Medicine ER -