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Small fiber neuropathy: A burning problem.
Cleve Clin J Med. 2009 May; 76(5):297-305.CC

Abstract

Small fiber neuropathy is increasingly being recognized as a major cause of painful burning sensations in the feet, especially in the elderly. Although strength remains preserved throughout the course of the disease, the pain and paresthesias are often disabling. Diabetes mellitus is the most common identifiable cause of small fiber neuropathy, and impaired oral glucose tolerance and individual components of the metabolic syndrome are often associated with it. Some cases, however, are idiopathic. Skin biopsy (with an evaluation of the density of intraepidermal nerve fibers) and tests of autonomic nerve function are useful for the diagnosis. Management involves controlling pain and identifying and aggressively treating the underlying cause.

Authors+Show Affiliations

Neuromuscular Disease Center, Neurological Institute, Cleveland Clinic Foundation, OH 44195, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19414545

Citation

Tavee, Jinny, and Lan Zhou. "Small Fiber Neuropathy: a Burning Problem." Cleveland Clinic Journal of Medicine, vol. 76, no. 5, 2009, pp. 297-305.
Tavee J, Zhou L. Small fiber neuropathy: A burning problem. Cleve Clin J Med. 2009;76(5):297-305.
Tavee, J., & Zhou, L. (2009). Small fiber neuropathy: A burning problem. Cleveland Clinic Journal of Medicine, 76(5), 297-305. https://doi.org/10.3949/ccjm.76a.08070
Tavee J, Zhou L. Small Fiber Neuropathy: a Burning Problem. Cleve Clin J Med. 2009;76(5):297-305. PubMed PMID: 19414545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small fiber neuropathy: A burning problem. AU - Tavee,Jinny, AU - Zhou,Lan, PY - 2009/5/6/entrez PY - 2009/5/6/pubmed PY - 2009/6/18/medline SP - 297 EP - 305 JF - Cleveland Clinic journal of medicine JO - Cleve Clin J Med VL - 76 IS - 5 N2 - Small fiber neuropathy is increasingly being recognized as a major cause of painful burning sensations in the feet, especially in the elderly. Although strength remains preserved throughout the course of the disease, the pain and paresthesias are often disabling. Diabetes mellitus is the most common identifiable cause of small fiber neuropathy, and impaired oral glucose tolerance and individual components of the metabolic syndrome are often associated with it. Some cases, however, are idiopathic. Skin biopsy (with an evaluation of the density of intraepidermal nerve fibers) and tests of autonomic nerve function are useful for the diagnosis. Management involves controlling pain and identifying and aggressively treating the underlying cause. SN - 1939-2869 UR - https://www.unboundmedicine.com/medline/citation/19414545/Small_fiber_neuropathy:_A_burning_problem_ L2 - https://www.ccjm.org/cgi/pmidlookup?view=long&pmid=19414545 DB - PRIME DP - Unbound Medicine ER -