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Intake of folate, vitamins B6, B12 and methionine and risk of pancreatic cancer in a large population-based case-control study.
Cancer Causes Control 2009; 20(8):1317-25CC

Abstract

OBJECTIVE

Folate and other methyl-group nutrients may play a key role in pancreatic carcinogenesis through their effects on DNA integrity. We examined the association between pancreatic cancer and intake of folate, vitamins B(6), B(12) and methionine in a large population-based case-control study.

METHODS

Risk factor data were collected during in-person interviews with 532 pancreatic cancer cases diagnosed in 1995-1999 and 1,701 frequency-matched controls in the San Francisco Bay Area. Dietary history and supplement use were obtained using a semi-quantitative food-frequency questionnaire developed at Harvard University. Adjusted unconditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) as estimates of the relative risk.

RESULTS

Total folate intake was inversely associated with pancreatic cancer (5th vs. 1st quintile: OR = 0.67, 95% CI = 0.48-0.93, p (trend) = 0.04). Increased vitamin B(12) from food was positively associated with pancreatic cancer although risk estimates for quintiles 3-5 were similar (5th vs. 1st quintile: OR = 1.9, 95% CI = 1.3-2.6, p (trend) = 0.001). Intake of vitamin B(6) or methionine was not associated with pancreatic cancer risk.

CONCLUSIONS

Our study provided some support for an inverse association between folate intake and pancreatic cancer risk. The increased pancreatic cancer risk with vitamin B(12) intake from food warrants further investigation.

Authors+Show Affiliations

Division of Cancer Epidemiology, Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 3333 California Street, Suite 280, San Francisco, CA 94118-1944, USA. zhihong.gong@ucsf.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

19415507

Citation

Gong, Zhihong, et al. "Intake of Folate, Vitamins B6, B12 and Methionine and Risk of Pancreatic Cancer in a Large Population-based Case-control Study." Cancer Causes & Control : CCC, vol. 20, no. 8, 2009, pp. 1317-25.
Gong Z, Holly EA, Bracci PM. Intake of folate, vitamins B6, B12 and methionine and risk of pancreatic cancer in a large population-based case-control study. Cancer Causes Control. 2009;20(8):1317-25.
Gong, Z., Holly, E. A., & Bracci, P. M. (2009). Intake of folate, vitamins B6, B12 and methionine and risk of pancreatic cancer in a large population-based case-control study. Cancer Causes & Control : CCC, 20(8), pp. 1317-25. doi:10.1007/s10552-009-9352-9.
Gong Z, Holly EA, Bracci PM. Intake of Folate, Vitamins B6, B12 and Methionine and Risk of Pancreatic Cancer in a Large Population-based Case-control Study. Cancer Causes Control. 2009;20(8):1317-25. PubMed PMID: 19415507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of folate, vitamins B6, B12 and methionine and risk of pancreatic cancer in a large population-based case-control study. AU - Gong,Zhihong, AU - Holly,Elizabeth A, AU - Bracci,Paige M, Y1 - 2009/05/05/ PY - 2008/12/15/received PY - 2009/04/17/accepted PY - 2009/5/6/entrez PY - 2009/5/6/pubmed PY - 2010/6/18/medline SP - 1317 EP - 25 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 20 IS - 8 N2 - OBJECTIVE: Folate and other methyl-group nutrients may play a key role in pancreatic carcinogenesis through their effects on DNA integrity. We examined the association between pancreatic cancer and intake of folate, vitamins B(6), B(12) and methionine in a large population-based case-control study. METHODS: Risk factor data were collected during in-person interviews with 532 pancreatic cancer cases diagnosed in 1995-1999 and 1,701 frequency-matched controls in the San Francisco Bay Area. Dietary history and supplement use were obtained using a semi-quantitative food-frequency questionnaire developed at Harvard University. Adjusted unconditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) as estimates of the relative risk. RESULTS: Total folate intake was inversely associated with pancreatic cancer (5th vs. 1st quintile: OR = 0.67, 95% CI = 0.48-0.93, p (trend) = 0.04). Increased vitamin B(12) from food was positively associated with pancreatic cancer although risk estimates for quintiles 3-5 were similar (5th vs. 1st quintile: OR = 1.9, 95% CI = 1.3-2.6, p (trend) = 0.001). Intake of vitamin B(6) or methionine was not associated with pancreatic cancer risk. CONCLUSIONS: Our study provided some support for an inverse association between folate intake and pancreatic cancer risk. The increased pancreatic cancer risk with vitamin B(12) intake from food warrants further investigation. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/19415507/Intake_of_folate_vitamins_B6_B12_and_methionine_and_risk_of_pancreatic_cancer_in_a_large_population_based_case_control_study_ L2 - https://doi.org/10.1007/s10552-009-9352-9 DB - PRIME DP - Unbound Medicine ER -