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Non-hormonal treatment of hot flushes in breast cancer survivors: gabapentin vs. vitamin E.
Climacteric. 2009 Aug; 12(4):310-8.C

Abstract

OBJECTIVES

To assess the efficacy and the tolerability of gabapentin 900 mg/day compared to vitamin E for the control of vasomotor symptoms in 115 women with breast cancer. The secondary objective was to evaluate the effect of the treatments on the quality of sleep and other aspects of the quality of life.

METHODS

A hot flush diary was completed daily; sleep quality and other menopausal symptoms were assessed with the Pittsburgh Sleep Quality Index (PSQI), the Menopause Rating Scale (MRS) and the SF-36 Health Survey.

RESULTS

The prescribed treatment with gabapentin was never started by 28.3% of the patients and was interrupted by 28% for side-effects (dizziness and somnolence). Among the women allocated to vitamin E, 16.36% never started therapy and 34.78% dropped out because of inefficacy. Hot flush frequency and score decreased by 57.05% and 66.87%, respectively (p < 0.05) in the gabapentin group. The effect of vitamin E was fairly small: hot flush frequency and score were reduced by 10.02% and 7.28%, respectively (p > 0.05). Gabapentin was also particularly effective in improving the quality of sleep (PSQI score reduction: 21.33%, p < 0.05).

CONCLUSION

Gabapentin appears to be effective for the treatment of hot flushes with a favorable effect on quality of sleep. Vitamin E has only marginal effect on vasomotor symptoms.

Authors+Show Affiliations

Department of Gynecological Oncology, University of Turin, Mauriziano 'Umberto I' Hospital and Institute for Cancer Research and Treatment of Candiolo (IRCC), Turin, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19415540

Citation

Biglia, N, et al. "Non-hormonal Treatment of Hot Flushes in Breast Cancer Survivors: Gabapentin Vs. Vitamin E." Climacteric : the Journal of the International Menopause Society, vol. 12, no. 4, 2009, pp. 310-8.
Biglia N, Sgandurra P, Peano E, et al. Non-hormonal treatment of hot flushes in breast cancer survivors: gabapentin vs. vitamin E. Climacteric. 2009;12(4):310-8.
Biglia, N., Sgandurra, P., Peano, E., Marenco, D., Moggio, G., Bounous, V., Tomasi Cont, N., Ponzone, R., & Sismondi, P. (2009). Non-hormonal treatment of hot flushes in breast cancer survivors: gabapentin vs. vitamin E. Climacteric : the Journal of the International Menopause Society, 12(4), 310-8. https://doi.org/10.1080/13697130902736921
Biglia N, et al. Non-hormonal Treatment of Hot Flushes in Breast Cancer Survivors: Gabapentin Vs. Vitamin E. Climacteric. 2009;12(4):310-8. PubMed PMID: 19415540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-hormonal treatment of hot flushes in breast cancer survivors: gabapentin vs. vitamin E. AU - Biglia,N, AU - Sgandurra,P, AU - Peano,E, AU - Marenco,D, AU - Moggio,G, AU - Bounous,V, AU - Tomasi Cont,N, AU - Ponzone,R, AU - Sismondi,P, PY - 2009/5/6/entrez PY - 2009/5/6/pubmed PY - 2010/2/18/medline SP - 310 EP - 8 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric VL - 12 IS - 4 N2 - OBJECTIVES: To assess the efficacy and the tolerability of gabapentin 900 mg/day compared to vitamin E for the control of vasomotor symptoms in 115 women with breast cancer. The secondary objective was to evaluate the effect of the treatments on the quality of sleep and other aspects of the quality of life. METHODS: A hot flush diary was completed daily; sleep quality and other menopausal symptoms were assessed with the Pittsburgh Sleep Quality Index (PSQI), the Menopause Rating Scale (MRS) and the SF-36 Health Survey. RESULTS: The prescribed treatment with gabapentin was never started by 28.3% of the patients and was interrupted by 28% for side-effects (dizziness and somnolence). Among the women allocated to vitamin E, 16.36% never started therapy and 34.78% dropped out because of inefficacy. Hot flush frequency and score decreased by 57.05% and 66.87%, respectively (p < 0.05) in the gabapentin group. The effect of vitamin E was fairly small: hot flush frequency and score were reduced by 10.02% and 7.28%, respectively (p > 0.05). Gabapentin was also particularly effective in improving the quality of sleep (PSQI score reduction: 21.33%, p < 0.05). CONCLUSION: Gabapentin appears to be effective for the treatment of hot flushes with a favorable effect on quality of sleep. Vitamin E has only marginal effect on vasomotor symptoms. SN - 1473-0804 UR - https://www.unboundmedicine.com/medline/citation/19415540/Non_hormonal_treatment_of_hot_flushes_in_breast_cancer_survivors:_gabapentin_vs__vitamin_E_ L2 - https://www.tandfonline.com/doi/full/10.1080/13697130902736921 DB - PRIME DP - Unbound Medicine ER -