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Therapeutic evaluation of UVB-targeted phototherapy in vitiligo that affects less than 10% of the body surface area.
Int J Dermatol. 2009 May; 48(5):529-34.IJ

Abstract

BACKGROUND

Current treatments for vitiligo include different therapeutic modalities, such as corticosteroids, immunomodulators, pseudocatalase, skin grafts, diverse types of phototherapy [ultraviolet B (UVB), psoralen plus UVA (PUVA), narrow-band UVB (NB-UVB)], and, recently, targeted phototherapy. After a literature search, we found only two studies using different targeted broad-band UVB units for the treatment of vitiligo.

OBJECTIVE

To evaluate the repigmentation response induced with broad-band, UVB-targeted phototherapy used as monotherapy in patients with vitiligo affecting less than 10% of the skin surface.

METHODS

Twelve patients were recruited for treatment with 30 sessions of UVB-targeted phototherapy administered twice weekly. The assessment of repigmentation was made from a comparison of baseline photographs with those after 30 sessions by two independent investigators. Morphometric analysis was performed using a computer program.

RESULTS

Repigmentation with an average of 66.25% was obtained on lesions of the face, and of 31.5% on the neck, trunk, and genitalia. On the extremities, there was no repigmentation. Itching, a burning sensation, erythema, desquamation, and transitory hyperpigmentation were observed in some patients. Minimal blistering and ulceration were observed in one patient.

CONCLUSION

Targeted UVB phototherapy seems to be effective for the repigmentation of vitiligo in lesions located on the face, to a lesser degree on the trunk, and with no response in acral lesions; there were minimal adverse effects that did not require discontinuation of treatment.

Authors+Show Affiliations

Department of Dermatology, University Hospital UANL Dr José Eleuterio González, Monterrey, Nuevo León, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

19416388

Citation

Welsh, Oliverio, et al. "Therapeutic Evaluation of UVB-targeted Phototherapy in Vitiligo That Affects Less Than 10% of the Body Surface Area." International Journal of Dermatology, vol. 48, no. 5, 2009, pp. 529-34.
Welsh O, Herz-Ruelas ME, Gómez M, et al. Therapeutic evaluation of UVB-targeted phototherapy in vitiligo that affects less than 10% of the body surface area. Int J Dermatol. 2009;48(5):529-34.
Welsh, O., Herz-Ruelas, M. E., Gómez, M., & Ocampo-Candiani, J. (2009). Therapeutic evaluation of UVB-targeted phototherapy in vitiligo that affects less than 10% of the body surface area. International Journal of Dermatology, 48(5), 529-34. https://doi.org/10.1111/j.1365-4632.2009.03928.x
Welsh O, et al. Therapeutic Evaluation of UVB-targeted Phototherapy in Vitiligo That Affects Less Than 10% of the Body Surface Area. Int J Dermatol. 2009;48(5):529-34. PubMed PMID: 19416388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic evaluation of UVB-targeted phototherapy in vitiligo that affects less than 10% of the body surface area. AU - Welsh,Oliverio, AU - Herz-Ruelas,M E, AU - Gómez,Minerva, AU - Ocampo-Candiani,Jorge, PY - 2009/5/7/entrez PY - 2009/5/7/pubmed PY - 2009/7/25/medline SP - 529 EP - 34 JF - International journal of dermatology JO - Int J Dermatol VL - 48 IS - 5 N2 - BACKGROUND: Current treatments for vitiligo include different therapeutic modalities, such as corticosteroids, immunomodulators, pseudocatalase, skin grafts, diverse types of phototherapy [ultraviolet B (UVB), psoralen plus UVA (PUVA), narrow-band UVB (NB-UVB)], and, recently, targeted phototherapy. After a literature search, we found only two studies using different targeted broad-band UVB units for the treatment of vitiligo. OBJECTIVE: To evaluate the repigmentation response induced with broad-band, UVB-targeted phototherapy used as monotherapy in patients with vitiligo affecting less than 10% of the skin surface. METHODS: Twelve patients were recruited for treatment with 30 sessions of UVB-targeted phototherapy administered twice weekly. The assessment of repigmentation was made from a comparison of baseline photographs with those after 30 sessions by two independent investigators. Morphometric analysis was performed using a computer program. RESULTS: Repigmentation with an average of 66.25% was obtained on lesions of the face, and of 31.5% on the neck, trunk, and genitalia. On the extremities, there was no repigmentation. Itching, a burning sensation, erythema, desquamation, and transitory hyperpigmentation were observed in some patients. Minimal blistering and ulceration were observed in one patient. CONCLUSION: Targeted UVB phototherapy seems to be effective for the repigmentation of vitiligo in lesions located on the face, to a lesser degree on the trunk, and with no response in acral lesions; there were minimal adverse effects that did not require discontinuation of treatment. SN - 1365-4632 UR - https://www.unboundmedicine.com/medline/citation/19416388/Therapeutic_evaluation_of_UVB_targeted_phototherapy_in_vitiligo_that_affects_less_than_10_of_the_body_surface_area_ DB - PRIME DP - Unbound Medicine ER -