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Plasma serotonin is a predictor for deterioration of urinary albumin excretion in men with type 2 diabetes mellitus.
Metabolism. 2009 Aug; 58(8):1076-9.M

Abstract

We performed an observational study to investigate if plasma 5-hydroxyindole-3-acetic acid (5-HIAA), a derivative end product of serotonin (5-hydroxytryptamine), concentration could be a predictor for deterioration of urinary albumin excretion. The relationship between baseline plasma 5-HIAA concentration and changes in urinary albumin excretion for 24 months was investigated in 162 male patients with type 2 diabetes mellitus. Patients were divided into tertiles according to plasma 5-HIAA concentration. Greater changes in urinary albumin excretion were seen in patients with high plasma 5-HIAA concentration (112.8 +/- 36.2 mg/g creatinine) than in patients with low plasma 5-HIAA concentration (7.6 +/- 8.0 mg/g creatinine, P = .0011) or in patients with intermediate plasma 5-HIAA concentration (25.6 +/- 15.0 mg/g creatinine, P = .0070) after adjustment for baseline values of urinary albumin excretion. A positive correlation was observed between log (plasma 5-HIAA concentration) and changes in urinary albumin excretion (r = 0.314, P < .0001). Multiple regression analysis demonstrated that log (plasma 5-HIAA concentration) (beta = .284, P = .0013) was an independent determinant of changes in urinary albumin excretion. In conclusion, plasma 5-HIAA concentration was positively correlated with changes in urinary albumin excretion, which may indicate causality in diabetic nephropathy in male patients with type 2 diabetes mellitus and high plasma 5-HIAA concentration.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kamigyo-ku, Kyoto 602-8566, Japan. sayarinapm@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19416792

Citation

Fukui, Michiaki, et al. "Plasma Serotonin Is a Predictor for Deterioration of Urinary Albumin Excretion in Men With Type 2 Diabetes Mellitus." Metabolism: Clinical and Experimental, vol. 58, no. 8, 2009, pp. 1076-9.
Fukui M, Shiraishi E, Tanaka M, et al. Plasma serotonin is a predictor for deterioration of urinary albumin excretion in men with type 2 diabetes mellitus. Metabolism. 2009;58(8):1076-9.
Fukui, M., Shiraishi, E., Tanaka, M., Senmaru, T., Sakabe, K., Harusato, I., Hasegawa, G., & Nakamura, N. (2009). Plasma serotonin is a predictor for deterioration of urinary albumin excretion in men with type 2 diabetes mellitus. Metabolism: Clinical and Experimental, 58(8), 1076-9. https://doi.org/10.1016/j.metabol.2009.03.009
Fukui M, et al. Plasma Serotonin Is a Predictor for Deterioration of Urinary Albumin Excretion in Men With Type 2 Diabetes Mellitus. Metabolism. 2009;58(8):1076-9. PubMed PMID: 19416792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma serotonin is a predictor for deterioration of urinary albumin excretion in men with type 2 diabetes mellitus. AU - Fukui,Michiaki, AU - Shiraishi,Emi, AU - Tanaka,Muhei, AU - Senmaru,Takafumi, AU - Sakabe,Kazumi, AU - Harusato,Ichiko, AU - Hasegawa,Goji, AU - Nakamura,Naoto, Y1 - 2009/06/18/ PY - 2009/02/02/received PY - 2009/03/09/revised PY - 2009/03/30/accepted PY - 2009/5/7/entrez PY - 2009/5/7/pubmed PY - 2009/8/12/medline SP - 1076 EP - 9 JF - Metabolism: clinical and experimental JO - Metabolism VL - 58 IS - 8 N2 - We performed an observational study to investigate if plasma 5-hydroxyindole-3-acetic acid (5-HIAA), a derivative end product of serotonin (5-hydroxytryptamine), concentration could be a predictor for deterioration of urinary albumin excretion. The relationship between baseline plasma 5-HIAA concentration and changes in urinary albumin excretion for 24 months was investigated in 162 male patients with type 2 diabetes mellitus. Patients were divided into tertiles according to plasma 5-HIAA concentration. Greater changes in urinary albumin excretion were seen in patients with high plasma 5-HIAA concentration (112.8 +/- 36.2 mg/g creatinine) than in patients with low plasma 5-HIAA concentration (7.6 +/- 8.0 mg/g creatinine, P = .0011) or in patients with intermediate plasma 5-HIAA concentration (25.6 +/- 15.0 mg/g creatinine, P = .0070) after adjustment for baseline values of urinary albumin excretion. A positive correlation was observed between log (plasma 5-HIAA concentration) and changes in urinary albumin excretion (r = 0.314, P < .0001). Multiple regression analysis demonstrated that log (plasma 5-HIAA concentration) (beta = .284, P = .0013) was an independent determinant of changes in urinary albumin excretion. In conclusion, plasma 5-HIAA concentration was positively correlated with changes in urinary albumin excretion, which may indicate causality in diabetic nephropathy in male patients with type 2 diabetes mellitus and high plasma 5-HIAA concentration. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19416792/Plasma_serotonin_is_a_predictor_for_deterioration_of_urinary_albumin_excretion_in_men_with_type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(09)00106-1 DB - PRIME DP - Unbound Medicine ER -