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Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories.
Psychopharmacology (Berl). 2009 Aug; 205(3):389-97.P

Abstract

RATIONALE

In humans, the retrieval of memories associated with an alcohol-related experience frequently evokes alcohol-seeking behaviour. The reconsolidation hypothesis states that a consolidated memory could again become labile and susceptible to disruption after memory retrieval.

OBJECTIVES

The aim of our study was to examine whether retrieval of alcohol-related memories undergoes a reconsolidation process.

METHODS

For this purpose, male Wistar rats were trained to self-administer ethanol in the presence of specific conditioned stimuli. Thereafter, animals were left undisturbed in their home cages for the following 21 days. Memory retrieval was performed in a single 5-min exposure to all alcohol-associated stimuli. The protein synthesis inhibitor anisomycin, the non-competitive N-methyl-D: -aspartate (NMDA) receptor antagonist MK-801 and acamprosate, a clinically used drug known to reduce a hyper-glutamatergic state, were given immediately after retrieval of alcohol-related memories. The impact of drug treatment on cue-induced alcohol-seeking behaviour was measured on the following day and 7 days later.

RESULTS

Administration of both anisomycin and MK-801 reduced cue-induced alcohol-seeking behaviour, showing that memory reconsolidation was disrupted by these compounds. However, acamprosate had no effect on the reconsolidation process, suggesting that this process is not dependent on a hyper-glutamatergic state but is more related to protein synthesis and NMDA receptor activity.

CONCLUSIONS

Pharmacological disruption of reconsolidation of alcohol-associated memories can be achieved by the use of NMDA antagonists and protein synthesis inhibitors and may thus provide a potential new therapeutic strategy for the prevention of relapse in alcohol addiction.

Authors+Show Affiliations

Department of Addictive Behaviour and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, J5, 68159 Mannheim, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19418040

Citation

von der Goltz, Christoph, et al. "Cue-induced Alcohol-seeking Behaviour Is Reduced By Disrupting the Reconsolidation of Alcohol-related Memories." Psychopharmacology, vol. 205, no. 3, 2009, pp. 389-97.
von der Goltz C, Vengeliene V, Bilbao A, et al. Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories. Psychopharmacology (Berl). 2009;205(3):389-97.
von der Goltz, C., Vengeliene, V., Bilbao, A., Perreau-Lenz, S., Pawlak, C. R., Kiefer, F., & Spanagel, R. (2009). Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories. Psychopharmacology, 205(3), 389-97. https://doi.org/10.1007/s00213-009-1544-1
von der Goltz C, et al. Cue-induced Alcohol-seeking Behaviour Is Reduced By Disrupting the Reconsolidation of Alcohol-related Memories. Psychopharmacology (Berl). 2009;205(3):389-97. PubMed PMID: 19418040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories. AU - von der Goltz,Christoph, AU - Vengeliene,Valentina, AU - Bilbao,Ainhoa, AU - Perreau-Lenz,Stephanie, AU - Pawlak,Cornelius R, AU - Kiefer,Falk, AU - Spanagel,Rainer, Y1 - 2009/05/06/ PY - 2008/12/20/received PY - 2009/04/15/accepted PY - 2009/5/7/entrez PY - 2009/5/7/pubmed PY - 2009/11/17/medline SP - 389 EP - 97 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 205 IS - 3 N2 - RATIONALE: In humans, the retrieval of memories associated with an alcohol-related experience frequently evokes alcohol-seeking behaviour. The reconsolidation hypothesis states that a consolidated memory could again become labile and susceptible to disruption after memory retrieval. OBJECTIVES: The aim of our study was to examine whether retrieval of alcohol-related memories undergoes a reconsolidation process. METHODS: For this purpose, male Wistar rats were trained to self-administer ethanol in the presence of specific conditioned stimuli. Thereafter, animals were left undisturbed in their home cages for the following 21 days. Memory retrieval was performed in a single 5-min exposure to all alcohol-associated stimuli. The protein synthesis inhibitor anisomycin, the non-competitive N-methyl-D: -aspartate (NMDA) receptor antagonist MK-801 and acamprosate, a clinically used drug known to reduce a hyper-glutamatergic state, were given immediately after retrieval of alcohol-related memories. The impact of drug treatment on cue-induced alcohol-seeking behaviour was measured on the following day and 7 days later. RESULTS: Administration of both anisomycin and MK-801 reduced cue-induced alcohol-seeking behaviour, showing that memory reconsolidation was disrupted by these compounds. However, acamprosate had no effect on the reconsolidation process, suggesting that this process is not dependent on a hyper-glutamatergic state but is more related to protein synthesis and NMDA receptor activity. CONCLUSIONS: Pharmacological disruption of reconsolidation of alcohol-associated memories can be achieved by the use of NMDA antagonists and protein synthesis inhibitors and may thus provide a potential new therapeutic strategy for the prevention of relapse in alcohol addiction. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/19418040/Cue_induced_alcohol_seeking_behaviour_is_reduced_by_disrupting_the_reconsolidation_of_alcohol_related_memories_ L2 - https://dx.doi.org/10.1007/s00213-009-1544-1 DB - PRIME DP - Unbound Medicine ER -