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Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury.
Free Radic Res. 2009 Jul; 43(7):631-45.FR

Abstract

The aim of the present study was to assess the effect of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in the pathophysiology of spinal cord injury (SCI) in mice. Spinal cord trauma was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy. SCI in mice resulted in severe trauma characterized by oedema, neutrophil infiltration, production of inflammatory mediators, tissue damage and apoptosis. ww-85 treatment (30-300 microg/kg, i.p. 1 h after the SCI) significantly reduced in a dose-dependent manner: (1) the degree of spinal cord inflammation and tissue injury, (2) neutrophil infiltration (myeloperoxidase activity), (3) nitrotyrosine formation and PARP activation, (4) pro-inflammatory cytokines expression, (5) NF-kappaB activation and (6) apoptosis. Moreover, ww-85 significantly ameliorated the recovery of limb function (evaluated by motor recovery score) in a dose-dependent manner. The results demonstrate that ww-85 treatment reduces the development of inflammation and tissue injury associated with spinal cord trauma.

Authors+Show Affiliations

IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19418318

Citation

Genovese, Tiziana, et al. "Effects of a Metalloporphyrinic Peroxynitrite Decomposition Catalyst, Ww-85, in a Mouse Model of Spinal Cord Injury." Free Radical Research, vol. 43, no. 7, 2009, pp. 631-45.
Genovese T, Mazzon E, Esposito E, et al. Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury. Free Radic Res. 2009;43(7):631-45.
Genovese, T., Mazzon, E., Esposito, E., Di Paola, R., Murthy, K., Neville, L., Bramanti, P., & Cuzzocrea, S. (2009). Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury. Free Radical Research, 43(7), 631-45. https://doi.org/10.1080/10715760902954126
Genovese T, et al. Effects of a Metalloporphyrinic Peroxynitrite Decomposition Catalyst, Ww-85, in a Mouse Model of Spinal Cord Injury. Free Radic Res. 2009;43(7):631-45. PubMed PMID: 19418318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury. AU - Genovese,Tiziana, AU - Mazzon,Emanuela, AU - Esposito,Emanuela, AU - Di Paola,Rosanna, AU - Murthy,Kanneganti, AU - Neville,Lewis, AU - Bramanti,Placido, AU - Cuzzocrea,Salvatore, PY - 2009/5/7/entrez PY - 2009/5/7/pubmed PY - 2009/8/28/medline SP - 631 EP - 45 JF - Free radical research JO - Free Radic Res VL - 43 IS - 7 N2 - The aim of the present study was to assess the effect of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in the pathophysiology of spinal cord injury (SCI) in mice. Spinal cord trauma was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy. SCI in mice resulted in severe trauma characterized by oedema, neutrophil infiltration, production of inflammatory mediators, tissue damage and apoptosis. ww-85 treatment (30-300 microg/kg, i.p. 1 h after the SCI) significantly reduced in a dose-dependent manner: (1) the degree of spinal cord inflammation and tissue injury, (2) neutrophil infiltration (myeloperoxidase activity), (3) nitrotyrosine formation and PARP activation, (4) pro-inflammatory cytokines expression, (5) NF-kappaB activation and (6) apoptosis. Moreover, ww-85 significantly ameliorated the recovery of limb function (evaluated by motor recovery score) in a dose-dependent manner. The results demonstrate that ww-85 treatment reduces the development of inflammation and tissue injury associated with spinal cord trauma. SN - 1029-2470 UR - https://www.unboundmedicine.com/medline/citation/19418318/Effects_of_a_metalloporphyrinic_peroxynitrite_decomposition_catalyst_ww_85_in_a_mouse_model_of_spinal_cord_injury_ L2 - https://www.tandfonline.com/doi/full/10.1080/10715760902954126 DB - PRIME DP - Unbound Medicine ER -