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Association of serum leptin levels with homeostasis model assessment-estimated insulin resistance and metabolic syndrome: the key role of central obesity.
Metab Syndr Relat Disord. 2009 Oct; 7(5):447-52.MS

Abstract

BACKGROUND

Leptin is correlated with several features of metabolic syndrome; however, possible confounders (eg, obesity) of this association are not known. This study evaluated the relationship between leptin, metabolic syndrome, and insulin resistance in an Iranian population and further investigated whether this relationship is confounded by obesity or central obesity.

METHODS

A total of 387 participants (18-65 years old) who referred to a large university general hospital for routine health examinations were categorized into 2 groups with (n = 130) and without (n = 257) metabolic syndrome. Fasting plasma glucose, insulin, lipids, and leptin levels were measured and the homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria.

RESULTS

Age- and sex-adjusted leptin levels were significantly higher in patients with than those without metabolic syndrome (29.62 +/- 1.67 vs. 18.50 +/- 1.21 ng/mL, P < 0.001). After adjustment for age, sex, and body mass index (BMI), leptin values were significantly correlated with HOMA-IR (P < 0.001), metabolic syndrome, and its components (P < 0.05). After adjustment for waist circumference, however, these associations were no longer statistically significant.

CONCLUSIONS

We demonstrated that high leptin levels are associated with insulin resistance and metabolic syndrome independent of BMI but these associations are significantly mediated through the effects of central obesity.

Authors+Show Affiliations

Endocrinology and Metabolism Research Center (EMRC), Vali-Asr hospital, Tehran University of Medical Sciences, Tehran, Iran. esteghamati@tums.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19419266

Citation

Esteghamati, Alireza, et al. "Association of Serum Leptin Levels With Homeostasis Model Assessment-estimated Insulin Resistance and Metabolic Syndrome: the Key Role of Central Obesity." Metabolic Syndrome and Related Disorders, vol. 7, no. 5, 2009, pp. 447-52.
Esteghamati A, Khalilzadeh O, Anvari M, et al. Association of serum leptin levels with homeostasis model assessment-estimated insulin resistance and metabolic syndrome: the key role of central obesity. Metab Syndr Relat Disord. 2009;7(5):447-52.
Esteghamati, A., Khalilzadeh, O., Anvari, M., Rashidi, A., Mokhtari, M., & Nakhjavani, M. (2009). Association of serum leptin levels with homeostasis model assessment-estimated insulin resistance and metabolic syndrome: the key role of central obesity. Metabolic Syndrome and Related Disorders, 7(5), 447-52. https://doi.org/10.1089/met.2008.0100
Esteghamati A, et al. Association of Serum Leptin Levels With Homeostasis Model Assessment-estimated Insulin Resistance and Metabolic Syndrome: the Key Role of Central Obesity. Metab Syndr Relat Disord. 2009;7(5):447-52. PubMed PMID: 19419266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of serum leptin levels with homeostasis model assessment-estimated insulin resistance and metabolic syndrome: the key role of central obesity. AU - Esteghamati,Alireza, AU - Khalilzadeh,Omid, AU - Anvari,Mehdi, AU - Rashidi,Armin, AU - Mokhtari,Mohammad, AU - Nakhjavani,Manouchehr, PY - 2009/5/8/entrez PY - 2009/5/8/pubmed PY - 2009/12/18/medline SP - 447 EP - 52 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 7 IS - 5 N2 - BACKGROUND: Leptin is correlated with several features of metabolic syndrome; however, possible confounders (eg, obesity) of this association are not known. This study evaluated the relationship between leptin, metabolic syndrome, and insulin resistance in an Iranian population and further investigated whether this relationship is confounded by obesity or central obesity. METHODS: A total of 387 participants (18-65 years old) who referred to a large university general hospital for routine health examinations were categorized into 2 groups with (n = 130) and without (n = 257) metabolic syndrome. Fasting plasma glucose, insulin, lipids, and leptin levels were measured and the homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. RESULTS: Age- and sex-adjusted leptin levels were significantly higher in patients with than those without metabolic syndrome (29.62 +/- 1.67 vs. 18.50 +/- 1.21 ng/mL, P < 0.001). After adjustment for age, sex, and body mass index (BMI), leptin values were significantly correlated with HOMA-IR (P < 0.001), metabolic syndrome, and its components (P < 0.05). After adjustment for waist circumference, however, these associations were no longer statistically significant. CONCLUSIONS: We demonstrated that high leptin levels are associated with insulin resistance and metabolic syndrome independent of BMI but these associations are significantly mediated through the effects of central obesity. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/19419266/Association_of_serum_leptin_levels_with_homeostasis_model_assessment_estimated_insulin_resistance_and_metabolic_syndrome:_the_key_role_of_central_obesity_ L2 - https://www.liebertpub.com/doi/full/10.1089/met.2008.0100?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -