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Loss of hip BMD in older men: the osteoporotic fractures in men (MrOS) study.
J Bone Miner Res. 2009 Oct; 24(10):1728-35.JB

Abstract

Previous studies in older men have not evaluated whether loss of BMD or BMC accelerates nonlinearly with age. This study aimed to describe hip bone loss (both in BMC and BMD) in older men and to test whether BMD loss accelerates with age in an exponential manner in a cohort of 4720 community-dwelling men >or=65 yr of age. Men had two to three measures of femoral neck (FN) BMD (by DXA) over an average follow-up of 4.6 yr. Change in BMD during follow-up was estimated from mixed effects regression models; the significance of a quadratic term for age was evaluated. Mean FN BMD loss was 0.013 g/cm(2) (-1.72%) during follow-up. The quadratic term for age was significant, and the model showed that bone loss accelerated with age. Estimated loss of FN BMD over follow-up for men 85 yr of age (0.021 g/cm(2)) was 2.5 times greater than the loss expected for men 65 yr of age (0.008 g/cm(2)); such bone loss in 85-yr-old men may be sufficient to increase the risk of hip fracture by 25% (HR per 0.021 g/cm(2) cross-sectional decrease in FN BMD: 1.25; 95% CI: 1.18-1.31) over 4.6 yr. Men with lower BMD at baseline lost the most BMD over follow-up. Although average bone loss over time is modest in older men, there is considerable variability in rate of loss. Older men and those with lower BMD lose bone more rapidly, offering potential explanation for the increasing risk of fracture with advancing age.

Authors+Show Affiliations

California Pacific Medical Center, Research Institute, San Francisco Coordinating Center, 185 Berry Street, Lobby 5, Suite 5700, San Francisco, CA 94107-1728, USA. pcawthon@sfcc-cpmc.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19419308

Citation

Cawthon, Peggy M., et al. "Loss of Hip BMD in Older Men: the Osteoporotic Fractures in Men (MrOS) Study." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 24, no. 10, 2009, pp. 1728-35.
Cawthon PM, Ewing SK, McCulloch CE, et al. Loss of hip BMD in older men: the osteoporotic fractures in men (MrOS) study. J Bone Miner Res. 2009;24(10):1728-35.
Cawthon, P. M., Ewing, S. K., McCulloch, C. E., Ensrud, K. E., Cauley, J. A., Cummings, S. R., & Orwoll, E. S. (2009). Loss of hip BMD in older men: the osteoporotic fractures in men (MrOS) study. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 24(10), 1728-35. https://doi.org/10.1359/jbmr.090419
Cawthon PM, et al. Loss of Hip BMD in Older Men: the Osteoporotic Fractures in Men (MrOS) Study. J Bone Miner Res. 2009;24(10):1728-35. PubMed PMID: 19419308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Loss of hip BMD in older men: the osteoporotic fractures in men (MrOS) study. AU - Cawthon,Peggy M, AU - Ewing,Susan K, AU - McCulloch,Charles E, AU - Ensrud,Kristine E, AU - Cauley,Jane A, AU - Cummings,Steven R, AU - Orwoll,Eric S, AU - ,, PY - 2009/5/8/entrez PY - 2009/5/8/pubmed PY - 2009/12/16/medline SP - 1728 EP - 35 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 24 IS - 10 N2 - Previous studies in older men have not evaluated whether loss of BMD or BMC accelerates nonlinearly with age. This study aimed to describe hip bone loss (both in BMC and BMD) in older men and to test whether BMD loss accelerates with age in an exponential manner in a cohort of 4720 community-dwelling men >or=65 yr of age. Men had two to three measures of femoral neck (FN) BMD (by DXA) over an average follow-up of 4.6 yr. Change in BMD during follow-up was estimated from mixed effects regression models; the significance of a quadratic term for age was evaluated. Mean FN BMD loss was 0.013 g/cm(2) (-1.72%) during follow-up. The quadratic term for age was significant, and the model showed that bone loss accelerated with age. Estimated loss of FN BMD over follow-up for men 85 yr of age (0.021 g/cm(2)) was 2.5 times greater than the loss expected for men 65 yr of age (0.008 g/cm(2)); such bone loss in 85-yr-old men may be sufficient to increase the risk of hip fracture by 25% (HR per 0.021 g/cm(2) cross-sectional decrease in FN BMD: 1.25; 95% CI: 1.18-1.31) over 4.6 yr. Men with lower BMD at baseline lost the most BMD over follow-up. Although average bone loss over time is modest in older men, there is considerable variability in rate of loss. Older men and those with lower BMD lose bone more rapidly, offering potential explanation for the increasing risk of fracture with advancing age. SN - 1523-4681 UR - https://www.unboundmedicine.com/medline/citation/19419308/Loss_of_hip_BMD_in_older_men:_the_osteoporotic_fractures_in_men__MrOS__study_ L2 - https://doi.org/10.1359/jbmr.090419 DB - PRIME DP - Unbound Medicine ER -