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Post-training excitotoxic lesions of the dorsal hippocampus attenuate generalization in auditory delay fear conditioning.
Eur J Neurosci. 2009 Apr; 29(8):1692-700.EJ

Abstract

An abundance of evidence indicates a role for the dorsal hippocampus (DH) in learning and memory. Pavlovian fear conditioning provides a useful model system in which to investigate DH function because conditioning to polymodal contextual cues, but generally not to discrete unimodal cues, depends upon the integrity of the DH. There is some suggestion that the hippocampus may be involved in generalization to discrete auditory stimuli following conditioning, but the available literature offers conflicting results regarding the nature of hippocampus involvement. The present experiments were designed to address a role for the DH in auditory generalization following delay fear conditioning. Rats were trained with two or 16 trials of delay fear conditioning and subsequently given a neurotoxic lesion of the DH or sham surgery. Upon recovery, they were tested for fear conditioned responding to the auditory stimulus they were trained with, as well as generalized responding to a novel auditory stimulus. Sham animals showed substantial generalization to the novel stimulus when trained with two or 16 trials. However, lesion animals showed much less generalization (better discriminative performance) to the novel stimulus following 16 conditioning trials while still showing substantial fear conditioned freezing to the trained stimulus. A second experiment showed that this effect was not the result of a non-associative response to the novel stimulus. We conclude that, with extended training, animals become capable of discriminating between trained and novel stimuli but another hippocampus-dependent process maintains generalized responding.

Authors+Show Affiliations

Department of Psychology and Center for Neuroscience & Behavior, Miami University, Oxford, OH 45056, USA. quinnjj@muohio.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19419430

Citation

Quinn, Jennifer J., et al. "Post-training Excitotoxic Lesions of the Dorsal Hippocampus Attenuate Generalization in Auditory Delay Fear Conditioning." The European Journal of Neuroscience, vol. 29, no. 8, 2009, pp. 1692-700.
Quinn JJ, Wied HM, Liu D, et al. Post-training excitotoxic lesions of the dorsal hippocampus attenuate generalization in auditory delay fear conditioning. Eur J Neurosci. 2009;29(8):1692-700.
Quinn, J. J., Wied, H. M., Liu, D., & Fanselow, M. S. (2009). Post-training excitotoxic lesions of the dorsal hippocampus attenuate generalization in auditory delay fear conditioning. The European Journal of Neuroscience, 29(8), 1692-700. https://doi.org/10.1111/j.1460-9568.2009.06727.x
Quinn JJ, et al. Post-training Excitotoxic Lesions of the Dorsal Hippocampus Attenuate Generalization in Auditory Delay Fear Conditioning. Eur J Neurosci. 2009;29(8):1692-700. PubMed PMID: 19419430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post-training excitotoxic lesions of the dorsal hippocampus attenuate generalization in auditory delay fear conditioning. AU - Quinn,Jennifer J, AU - Wied,Heather M, AU - Liu,Dorothy, AU - Fanselow,Michael S, PY - 2009/5/8/entrez PY - 2009/5/8/pubmed PY - 2009/7/14/medline SP - 1692 EP - 700 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 29 IS - 8 N2 - An abundance of evidence indicates a role for the dorsal hippocampus (DH) in learning and memory. Pavlovian fear conditioning provides a useful model system in which to investigate DH function because conditioning to polymodal contextual cues, but generally not to discrete unimodal cues, depends upon the integrity of the DH. There is some suggestion that the hippocampus may be involved in generalization to discrete auditory stimuli following conditioning, but the available literature offers conflicting results regarding the nature of hippocampus involvement. The present experiments were designed to address a role for the DH in auditory generalization following delay fear conditioning. Rats were trained with two or 16 trials of delay fear conditioning and subsequently given a neurotoxic lesion of the DH or sham surgery. Upon recovery, they were tested for fear conditioned responding to the auditory stimulus they were trained with, as well as generalized responding to a novel auditory stimulus. Sham animals showed substantial generalization to the novel stimulus when trained with two or 16 trials. However, lesion animals showed much less generalization (better discriminative performance) to the novel stimulus following 16 conditioning trials while still showing substantial fear conditioned freezing to the trained stimulus. A second experiment showed that this effect was not the result of a non-associative response to the novel stimulus. We conclude that, with extended training, animals become capable of discriminating between trained and novel stimuli but another hippocampus-dependent process maintains generalized responding. SN - 1460-9568 UR - https://www.unboundmedicine.com/medline/citation/19419430/Post_training_excitotoxic_lesions_of_the_dorsal_hippocampus_attenuate_generalization_in_auditory_delay_fear_conditioning_ L2 - https://doi.org/10.1111/j.1460-9568.2009.06727.x DB - PRIME DP - Unbound Medicine ER -