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Plasma C-reactive protein is related to cognitive deterioration and dementia in patients with mild cognitive impairment.
J Neurol Sci. 2009 Sep 15; 284(1-2):77-80.JN

Abstract

OBJECTIVE

To investigate the relationship between plasma C-reactive protein (CRP) and the risk for cognitive deterioration and development of dementia in patients with mild cognitive impairment (MCI).

METHODS

Elderly Chinese patients with suspected cognitive impairment were screened. A total of 168 patients who met the criteria for MCI were enrolled. Plasma CRP levels were measured at baseline. The global cognitive functions were assessed at baseline and during follow-up periodically with Mini-Mental State Examination (MMSE). All enrolled patients were followed and evaluated regularly for 2 years to determine if the patients developed dementia.

RESULTS

Of the 168 patients with MCI diagnosed at baseline, 14 (8.3%) deceased, 13 (7.7%) lost to follow-up, and 58 (34.5%) developed dementia during follow-up. MMSE score of the enrolled patients declined significantly during follow-up (22.1 +/- 3.0 vs 18.6 +/- 5.5, P < 0.001). MMSE score was significantly lower for the patients with high CRP levels than that for those with low plasma CRP levels (-4.9 +/- 5.4 vs -3.2 +/- 4.2, P < 0.05). Patients with high plasma CRP level had an increased risk for dementia and vascular dementia as compared with patients with low level of plasma CRP (Log rank test, P < 0.05).

CONCLUSION

High plasma CRP level was associated with accelerated cognitive decline and increased risk for dementia in patients with MCI.

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Authors+Show Affiliations

Xu G
Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305# East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China. gelinxu@gmail.com
Zhou Z
No affiliation info available
Zhu W
No affiliation info available
Fan X
No affiliation info available
Liu X
No affiliation info available

MeSH

AgedAlcohol DrinkingC-Reactive ProteinCardiovascular DiseasesChinaCognition DisordersComorbidityDementiaDiabetes MellitusDisease ProgressionFemaleFollow-Up StudiesHumansHyperlipidemiasIncidenceMaleMiddle AgedPsychiatric Status Rating ScalesRiskSmoking

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19419739

Citation

Xu, Gelin, et al. "Plasma C-reactive Protein Is Related to Cognitive Deterioration and Dementia in Patients With Mild Cognitive Impairment." Journal of the Neurological Sciences, vol. 284, no. 1-2, 2009, pp. 77-80.
Xu G, Zhou Z, Zhu W, et al. Plasma C-reactive protein is related to cognitive deterioration and dementia in patients with mild cognitive impairment. J Neurol Sci. 2009;284(1-2):77-80.
Xu, G., Zhou, Z., Zhu, W., Fan, X., & Liu, X. (2009). Plasma C-reactive protein is related to cognitive deterioration and dementia in patients with mild cognitive impairment. Journal of the Neurological Sciences, 284(1-2), 77-80. https://doi.org/10.1016/j.jns.2009.04.018
Xu G, et al. Plasma C-reactive Protein Is Related to Cognitive Deterioration and Dementia in Patients With Mild Cognitive Impairment. J Neurol Sci. 2009 Sep 15;284(1-2):77-80. PubMed PMID: 19419739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma C-reactive protein is related to cognitive deterioration and dementia in patients with mild cognitive impairment. AU - Xu,Gelin, AU - Zhou,Zhiming, AU - Zhu,Wusheng, AU - Fan,Xiaobing, AU - Liu,Xinfeng, Y1 - 2009/05/05/ PY - 2008/11/27/received PY - 2009/04/12/revised PY - 2009/04/14/accepted PY - 2009/5/8/entrez PY - 2009/5/8/pubmed PY - 2009/12/16/medline SP - 77 EP - 80 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 284 IS - 1-2 N2 - OBJECTIVE: To investigate the relationship between plasma C-reactive protein (CRP) and the risk for cognitive deterioration and development of dementia in patients with mild cognitive impairment (MCI). METHODS: Elderly Chinese patients with suspected cognitive impairment were screened. A total of 168 patients who met the criteria for MCI were enrolled. Plasma CRP levels were measured at baseline. The global cognitive functions were assessed at baseline and during follow-up periodically with Mini-Mental State Examination (MMSE). All enrolled patients were followed and evaluated regularly for 2 years to determine if the patients developed dementia. RESULTS: Of the 168 patients with MCI diagnosed at baseline, 14 (8.3%) deceased, 13 (7.7%) lost to follow-up, and 58 (34.5%) developed dementia during follow-up. MMSE score of the enrolled patients declined significantly during follow-up (22.1 +/- 3.0 vs 18.6 +/- 5.5, P < 0.001). MMSE score was significantly lower for the patients with high CRP levels than that for those with low plasma CRP levels (-4.9 +/- 5.4 vs -3.2 +/- 4.2, P < 0.05). Patients with high plasma CRP level had an increased risk for dementia and vascular dementia as compared with patients with low level of plasma CRP (Log rank test, P < 0.05). CONCLUSION: High plasma CRP level was associated with accelerated cognitive decline and increased risk for dementia in patients with MCI. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/19419739/Plasma_C_reactive_protein_is_related_to_cognitive_deterioration_and_dementia_in_patients_with_mild_cognitive_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(09)00561-9 DB - PRIME DP - Unbound Medicine ER -