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Plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G promoter polymorphism is seen in higher frequency in the Indian patients with deep vein thrombosis.
Clin Appl Thromb Hemost. 2010 Apr; 16(2):184-8.CA

Abstract

INTRODUCTION

A number of prothrombotic and fibrinolytic disorders may lead to venous thrombosis. A 4G/5G polymorphism located in the promoter region of plasminogen activator inhibitor-1 (PAI-1) gene has been found to be commonly associated with the levels of PAI-1 and might be a risk factor for deep vein thrombosis (DVT). The aim of this study was to look for the potential association of this polymorphism with DVT in the Asian Indian population.

MATERIAL AND METHODS

A total of 110 consecutive patients (M:F = 62:48) with idiopathic DVT and equal number of age- and sex-matched healthy controls were the study participants. All study participants were typed for the PAI-1 4G/ 5G polymorphism, factor V Leiden, factor V Hong Kong/Cambridge mutations, and HR2 haplotype.

RESULT

The variant allele for the PAI-1 4G/5G polymorphism showed both genotypic (P = .0013, chi(2) = 10.303; odds ratio [OR] = 3.75) as well as allelic association (P = .0004, chi(2) = 12.273; OR = 1.99) with DVT. Factor V Leiden and factor V HR2 haplotype were observed in 10 (9.0%) and 13 (11.8%) patients, respectively. None of the study participants showed the factor V Hong Kong Cambridge mutations.

CONCLUSION

Our study shows the association of 4G allele with DVT in Asian Indian population. The higher prevalence of 4G polymorphism in patients with DVT (compared with controls) seen in our study is in concordance with previous reports from the Caucasian population.

Authors+Show Affiliations

All India Institute of Medical Sciences, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19419975

Citation

Akhter, Mohammed Suhail, et al. "Plasminogen Activator Inhibitor-1 (PAI-1) Gene 4G/5G Promoter Polymorphism Is Seen in Higher Frequency in the Indian Patients With Deep Vein Thrombosis." Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, vol. 16, no. 2, 2010, pp. 184-8.
Akhter MS, Biswas A, Ranjan R, et al. Plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G promoter polymorphism is seen in higher frequency in the Indian patients with deep vein thrombosis. Clin Appl Thromb Hemost. 2010;16(2):184-8.
Akhter, M. S., Biswas, A., Ranjan, R., Meena, A., Yadav, B. K., Sharma, A., & Saxena, R. (2010). Plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G promoter polymorphism is seen in higher frequency in the Indian patients with deep vein thrombosis. Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 16(2), 184-8. https://doi.org/10.1177/1076029609333673
Akhter MS, et al. Plasminogen Activator Inhibitor-1 (PAI-1) Gene 4G/5G Promoter Polymorphism Is Seen in Higher Frequency in the Indian Patients With Deep Vein Thrombosis. Clin Appl Thromb Hemost. 2010;16(2):184-8. PubMed PMID: 19419975.
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TY - JOUR T1 - Plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G promoter polymorphism is seen in higher frequency in the Indian patients with deep vein thrombosis. AU - Akhter,Mohammed Suhail, AU - Biswas,Arijit, AU - Ranjan,Ravi, AU - Meena,Arvind, AU - Yadav,Birendra Kumar, AU - Sharma,Amit, AU - Saxena,Renu, Y1 - 2009/05/05/ PY - 2009/5/8/entrez PY - 2009/5/8/pubmed PY - 2010/6/25/medline SP - 184 EP - 8 JF - Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis JO - Clin Appl Thromb Hemost VL - 16 IS - 2 N2 - INTRODUCTION: A number of prothrombotic and fibrinolytic disorders may lead to venous thrombosis. A 4G/5G polymorphism located in the promoter region of plasminogen activator inhibitor-1 (PAI-1) gene has been found to be commonly associated with the levels of PAI-1 and might be a risk factor for deep vein thrombosis (DVT). The aim of this study was to look for the potential association of this polymorphism with DVT in the Asian Indian population. MATERIAL AND METHODS: A total of 110 consecutive patients (M:F = 62:48) with idiopathic DVT and equal number of age- and sex-matched healthy controls were the study participants. All study participants were typed for the PAI-1 4G/ 5G polymorphism, factor V Leiden, factor V Hong Kong/Cambridge mutations, and HR2 haplotype. RESULT: The variant allele for the PAI-1 4G/5G polymorphism showed both genotypic (P = .0013, chi(2) = 10.303; odds ratio [OR] = 3.75) as well as allelic association (P = .0004, chi(2) = 12.273; OR = 1.99) with DVT. Factor V Leiden and factor V HR2 haplotype were observed in 10 (9.0%) and 13 (11.8%) patients, respectively. None of the study participants showed the factor V Hong Kong Cambridge mutations. CONCLUSION: Our study shows the association of 4G allele with DVT in Asian Indian population. The higher prevalence of 4G polymorphism in patients with DVT (compared with controls) seen in our study is in concordance with previous reports from the Caucasian population. SN - 1938-2723 UR - https://www.unboundmedicine.com/medline/citation/19419975/Plasminogen_activator_inhibitor_1__PAI_1__gene_4G/5G_promoter_polymorphism_is_seen_in_higher_frequency_in_the_Indian_patients_with_deep_vein_thrombosis_ L2 - https://journals.sagepub.com/doi/10.1177/1076029609333673?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -