Tags

Type your tag names separated by a space and hit enter

A positive breath hydrogen test does not predict the occurrence of a spontaneous bacterial peritonitis in cirrhotic patients with ascites.
Digestion 2009; 79(4):252-8D

Abstract

BACKGROUND/AIMS

A positive breath hydrogen test (BH(2) T) suggesting the presence of a small intestinal bacterial overgrowth (SIBO) might be a factor increasing the risk of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. In this prospective observational study, we aimed to determine whether a positive BH(2) T was associated in time with the development of SBP in cirrhotics with ascites.

METHODS

During a 3-year period, we prospectively included 29 consecutive cirrhotics with ascites but without previous episodes of SBP or recent antibiotherapy. Every 3 months or before in the event of cirrhosis complications, patients underwent clinical examination, routine laboratory tests, analysis of ascitic fluid and a BH(2) T after ingestion of 50 g D-glucose.

RESULTS

During a mean follow-up of 12 months (range 3-33), 11 patients were prematurely withdrawn from the study without SBP (3 transplantations, 2 lost to follow-up, 6 deaths from hepatorenal syndrome, terminal liver failure, variceal bleeding or septic shock) and 9 developed SBP. In the 29 patients, 116 BH(2) T were performed and were positive 12 times in 8 patients; however, in the same patient the positivity was not constant during the follow-up and not related to the clinical presence of ascites. Among the 9 patients who developed SBP, only 2 had a previous transitory positive BH(2) T, which became negative at least 3 months before the occurrence of SBP.

CONCLUSION

In cirrhotics with ascites the diagnosis of SBP is not associated in time with a recent positive BH(2) T.

Authors+Show Affiliations

Université de Lyon, Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

19420942

Citation

Nancey, Stéphane, et al. "A Positive Breath Hydrogen Test Does Not Predict the Occurrence of a Spontaneous Bacterial Peritonitis in Cirrhotic Patients With Ascites." Digestion, vol. 79, no. 4, 2009, pp. 252-8.
Nancey S, Moussata D, Roman S, et al. A positive breath hydrogen test does not predict the occurrence of a spontaneous bacterial peritonitis in cirrhotic patients with ascites. Digestion. 2009;79(4):252-8.
Nancey, S., Moussata, D., Roman, S., Benmansour, H., Claudel, S., & Flourié, B. (2009). A positive breath hydrogen test does not predict the occurrence of a spontaneous bacterial peritonitis in cirrhotic patients with ascites. Digestion, 79(4), pp. 252-8. doi:10.1159/000215617.
Nancey S, et al. A Positive Breath Hydrogen Test Does Not Predict the Occurrence of a Spontaneous Bacterial Peritonitis in Cirrhotic Patients With Ascites. Digestion. 2009;79(4):252-8. PubMed PMID: 19420942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A positive breath hydrogen test does not predict the occurrence of a spontaneous bacterial peritonitis in cirrhotic patients with ascites. AU - Nancey,Stéphane, AU - Moussata,Driffa, AU - Roman,Sabine, AU - Benmansour,Hédia, AU - Claudel,Sylvette, AU - Flourié,Bernard, Y1 - 2009/05/07/ PY - 2008/12/17/received PY - 2009/03/19/accepted PY - 2009/5/8/entrez PY - 2009/5/8/pubmed PY - 2009/8/19/medline SP - 252 EP - 8 JF - Digestion JO - Digestion VL - 79 IS - 4 N2 - BACKGROUND/AIMS: A positive breath hydrogen test (BH(2) T) suggesting the presence of a small intestinal bacterial overgrowth (SIBO) might be a factor increasing the risk of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. In this prospective observational study, we aimed to determine whether a positive BH(2) T was associated in time with the development of SBP in cirrhotics with ascites. METHODS: During a 3-year period, we prospectively included 29 consecutive cirrhotics with ascites but without previous episodes of SBP or recent antibiotherapy. Every 3 months or before in the event of cirrhosis complications, patients underwent clinical examination, routine laboratory tests, analysis of ascitic fluid and a BH(2) T after ingestion of 50 g D-glucose. RESULTS: During a mean follow-up of 12 months (range 3-33), 11 patients were prematurely withdrawn from the study without SBP (3 transplantations, 2 lost to follow-up, 6 deaths from hepatorenal syndrome, terminal liver failure, variceal bleeding or septic shock) and 9 developed SBP. In the 29 patients, 116 BH(2) T were performed and were positive 12 times in 8 patients; however, in the same patient the positivity was not constant during the follow-up and not related to the clinical presence of ascites. Among the 9 patients who developed SBP, only 2 had a previous transitory positive BH(2) T, which became negative at least 3 months before the occurrence of SBP. CONCLUSION: In cirrhotics with ascites the diagnosis of SBP is not associated in time with a recent positive BH(2) T. SN - 1421-9867 UR - https://www.unboundmedicine.com/medline/citation/19420942/A_positive_breath_hydrogen_test_does_not_predict_the_occurrence_of_a_spontaneous_bacterial_peritonitis_in_cirrhotic_patients_with_ascites_ L2 - https://www.karger.com?DOI=10.1159/000215617 DB - PRIME DP - Unbound Medicine ER -