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The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition.
Cancer Epidemiol Biomarkers Prev 2009; 18(5):1333-40CE

Abstract

Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products.

Authors+Show Affiliations

Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK. francesca.crowe@ceu.ox.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19423514

Citation

Crowe, Francesca L., et al. "The Association Between Diet and Serum Concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation Into Cancer and Nutrition." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 18, no. 5, 2009, pp. 1333-40.
Crowe FL, Key TJ, Allen NE, et al. The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev. 2009;18(5):1333-40.
Crowe, F. L., Key, T. J., Allen, N. E., Appleby, P. N., Roddam, A., Overvad, K., ... Kaaks, R. (2009). The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 18(5), pp. 1333-40. doi:10.1158/1055-9965.EPI-08-0781.
Crowe FL, et al. The Association Between Diet and Serum Concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation Into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev. 2009;18(5):1333-40. PubMed PMID: 19423514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition. AU - Crowe,Francesca L, AU - Key,Timothy J, AU - Allen,Naomi E, AU - Appleby,Paul N, AU - Roddam,Andrew, AU - Overvad,Kim, AU - Grønbaek,Henning, AU - Tjønneland,Anne, AU - Halkjaer,Jutte, AU - Dossus,Laure, AU - Boeing,Heiner, AU - Kröger,Janine, AU - Trichopoulou,Antonia, AU - Dilis,Vardis, AU - Trichopoulos,Dimitrios, AU - Boutron-Ruault,Marie-Christine, AU - De Lauzon,Blandine, AU - Clavel-Chapelon,Françoise, AU - Palli,Domenico, AU - Berrino,Franco, AU - Panico,Salvatore, AU - Tumino,Rosario, AU - Sacerdote,Carlotta, AU - Bueno-de-Mesquita,H Bas, AU - Vrieling,Alina, AU - van Gils,Carla H, AU - Peeters,Petra H M, AU - Gram,Inger T, AU - Skeie,Guri, AU - Lund,Eiliv, AU - Rodríguez,Laudina, AU - Jakszyn,Paula, AU - Molina-Montes,Esther, AU - Tormo,María J, AU - Barricarte,Aurelio, AU - Larrañaga,Nerea, AU - Khaw,Kay-Tee, AU - Bingham,Sheila, AU - Rinaldi,Sabina, AU - Slimani,Nadia, AU - Norat,Teresa, AU - Gallo,Valentina, AU - Riboli,Elio, AU - Kaaks,Rudolf, PY - 2009/5/9/entrez PY - 2009/5/9/pubmed PY - 2009/6/26/medline SP - 1333 EP - 40 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 18 IS - 5 N2 - Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/19423514/The_association_between_diet_and_serum_concentrations_of_IGF_I_IGFBP_1_IGFBP_2_and_IGFBP_3_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=19423514 DB - PRIME DP - Unbound Medicine ER -