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What role for [black triangle down] colesevelam in cardiovascular prevention?
Drug Ther Bull. 2009 May; 47(5):53-5.DT

Abstract

As concentrations of blood total cholesterol (and LDL-cholesterol) increase, so does the risk of cardiovascular disease (CVD). Bile acid sequestrants (otherwise known as resins), were among the first lipid-altering drugs shown capable of reducing the risk of coronary heart disease in clinical trials; more recently, lowering lipid concentrations by the use of statins (HMG coA-reductase inhibitors) has been proven to reduce cardiovascular and total mortality and these drugs are now recommended as first-line therapy in both primary and secondary CVD prevention. Colesevelam ([see symbol in text] Cholestagel--Genzyme), a new bile acid sequestrant, is licensed for use in the management of primary hypercholesterolaemia, either as monotherapy when statins are not tolerated or considered inappropriate, or as an adjunct to statin therapy in patients who are not adequately controlled on a statin alone. Here, we discuss whether colesevelam has a useful role in these settings.

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MeSH

AllylamineAnticholesteremic AgentsAzetidinesCardiovascular DiseasesColesevelam HydrochlorideDrug Therapy, CombinationEzetimibeHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaTreatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19423677

Citation

"What Role for [black Triangle Down] Colesevelam in Cardiovascular Prevention?" Drug and Therapeutics Bulletin, vol. 47, no. 5, 2009, pp. 53-5.
What role for [black triangle down] colesevelam in cardiovascular prevention? Drug Ther Bull. 2009;47(5):53-5.
(2009). What role for [black triangle down] colesevelam in cardiovascular prevention? Drug and Therapeutics Bulletin, 47(5), 53-5. https://doi.org/10.1136/dtb.2009.04.0015
What Role for [black Triangle Down] Colesevelam in Cardiovascular Prevention. Drug Ther Bull. 2009;47(5):53-5. PubMed PMID: 19423677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What role for [black triangle down] colesevelam in cardiovascular prevention? PY - 2009/5/9/entrez PY - 2009/5/9/pubmed PY - 2010/3/5/medline SP - 53 EP - 5 JF - Drug and therapeutics bulletin JO - Drug Ther Bull VL - 47 IS - 5 N2 - As concentrations of blood total cholesterol (and LDL-cholesterol) increase, so does the risk of cardiovascular disease (CVD). Bile acid sequestrants (otherwise known as resins), were among the first lipid-altering drugs shown capable of reducing the risk of coronary heart disease in clinical trials; more recently, lowering lipid concentrations by the use of statins (HMG coA-reductase inhibitors) has been proven to reduce cardiovascular and total mortality and these drugs are now recommended as first-line therapy in both primary and secondary CVD prevention. Colesevelam ([see symbol in text] Cholestagel--Genzyme), a new bile acid sequestrant, is licensed for use in the management of primary hypercholesterolaemia, either as monotherapy when statins are not tolerated or considered inappropriate, or as an adjunct to statin therapy in patients who are not adequately controlled on a statin alone. Here, we discuss whether colesevelam has a useful role in these settings. SN - 0012-6543 UR - https://www.unboundmedicine.com/medline/citation/19423677/What_role_for_[black_triangle_down]_colesevelam_in_cardiovascular_prevention L2 - https://dtb.bmj.com/lookup/pmidlookup?view=long&pmid=19423677 DB - PRIME DP - Unbound Medicine ER -