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Contributions of dust exposure and cigarette smoking to emphysema severity in coal miners in the United States.
Am J Respir Crit Care Med 2009; 180(3):257-64AJ

Abstract

RATIONALE

Previous studies have shown associations between dust exposure or lung burden and emphysema in coal miners, although the separate contributions of various predictors have not been clearly demonstrated.

OBJECTIVES

To quantitatively evaluate the relationship between cumulative exposure to respirable coal mine dust, cigarette smoking, and other factors on emphysema severity.

METHODS

The study group included 722 autopsied coal miners and nonminers in the United States. Data on work history, smoking, race, and age at death were obtained from medical records and questionnaire completed by next-of-kin. Emphysema was classified and graded using a standardized schema. Job-specific mean concentrations of respirable coal mine dust were matched with work histories to estimate cumulative exposure. Relationships between various metrics of dust exposure (including cumulative exposure and lung dust burden) and emphysema severity were investigated in weighted least squares regression models.

MEASUREMENTS AND MAIN RESULTS

Emphysema severity was significantly elevated in coal miners compared with nonminers among ever- and never-smokers (P < 0.0001). Cumulative exposure to respirable coal mine dust or coal dust retained in the lungs were significant predictors of emphysema severity (P < 0.0001) after accounting for cigarette smoking, age at death, and race. The contributions of coal mine dust exposure and cigarette smoking were similar in predicting emphysema severity averaged over this cohort.

CONCLUSIONS

Coal dust exposure, cigarette smoking, age, and race are significant and additive predictors of emphysema severity in this study.

Authors+Show Affiliations

National Institute for Occupational Safety and Health, Education and Information Division, Risk Evaluation Branch, Cincinnati, Ohio 45226-1998, USA. ekuempel@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

19423717

Citation

Kuempel, Eileen D., et al. "Contributions of Dust Exposure and Cigarette Smoking to Emphysema Severity in Coal Miners in the United States." American Journal of Respiratory and Critical Care Medicine, vol. 180, no. 3, 2009, pp. 257-64.
Kuempel ED, Wheeler MW, Smith RJ, et al. Contributions of dust exposure and cigarette smoking to emphysema severity in coal miners in the United States. Am J Respir Crit Care Med. 2009;180(3):257-64.
Kuempel, E. D., Wheeler, M. W., Smith, R. J., Vallyathan, V., & Green, F. H. (2009). Contributions of dust exposure and cigarette smoking to emphysema severity in coal miners in the United States. American Journal of Respiratory and Critical Care Medicine, 180(3), pp. 257-64. doi:10.1164/rccm.200806-840OC.
Kuempel ED, et al. Contributions of Dust Exposure and Cigarette Smoking to Emphysema Severity in Coal Miners in the United States. Am J Respir Crit Care Med. 2009 Aug 1;180(3):257-64. PubMed PMID: 19423717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contributions of dust exposure and cigarette smoking to emphysema severity in coal miners in the United States. AU - Kuempel,Eileen D, AU - Wheeler,Matthew W, AU - Smith,Randall J, AU - Vallyathan,Val, AU - Green,Francis H Y, Y1 - 2009/05/07/ PY - 2009/5/9/entrez PY - 2009/5/9/pubmed PY - 2009/8/7/medline SP - 257 EP - 64 JF - American journal of respiratory and critical care medicine JO - Am. J. Respir. Crit. Care Med. VL - 180 IS - 3 N2 - RATIONALE: Previous studies have shown associations between dust exposure or lung burden and emphysema in coal miners, although the separate contributions of various predictors have not been clearly demonstrated. OBJECTIVES: To quantitatively evaluate the relationship between cumulative exposure to respirable coal mine dust, cigarette smoking, and other factors on emphysema severity. METHODS: The study group included 722 autopsied coal miners and nonminers in the United States. Data on work history, smoking, race, and age at death were obtained from medical records and questionnaire completed by next-of-kin. Emphysema was classified and graded using a standardized schema. Job-specific mean concentrations of respirable coal mine dust were matched with work histories to estimate cumulative exposure. Relationships between various metrics of dust exposure (including cumulative exposure and lung dust burden) and emphysema severity were investigated in weighted least squares regression models. MEASUREMENTS AND MAIN RESULTS: Emphysema severity was significantly elevated in coal miners compared with nonminers among ever- and never-smokers (P < 0.0001). Cumulative exposure to respirable coal mine dust or coal dust retained in the lungs were significant predictors of emphysema severity (P < 0.0001) after accounting for cigarette smoking, age at death, and race. The contributions of coal mine dust exposure and cigarette smoking were similar in predicting emphysema severity averaged over this cohort. CONCLUSIONS: Coal dust exposure, cigarette smoking, age, and race are significant and additive predictors of emphysema severity in this study. SN - 1535-4970 UR - https://www.unboundmedicine.com/medline/citation/19423717/full_citation L2 - http://www.atsjournals.org/doi/full/10.1164/rccm.200806-840OC?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -