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The effects of gabapentin on acute and chronic pain after inguinal herniorrhaphy.
Eur J Anaesthesiol. 2009 Sep; 26(9):772-6.EJ

Abstract

BACKGROUND AND OBJECTIVE

To find out whether preoperative gabapentin use had a favourable effect on long-term postoperative pain in patients undergoing inguinal herniorrhaphy.

METHODS

Sixty male patients--aged 20-40 years--who were scheduled for unilateral inguinal herniorrhaphy under spinal anaesthesia were included in this prospective, randomized, double-blind study. The patients were randomly allocated to two groups: the gabapentin group (n=30) received single-dose 1.2 g oral gabapentin 1 h before surgery, and the placebo group received a placebo capsule instead. Spinal anaesthesia was performed with heavy bupivacaine, and all operations were performed by the same surgeon with the same technique. Postoperative analgesia was evaluated during sitting and lying with a visual analogue scale. Assessment of postoperative pain at 1, 3 and 6 months was carried out with an 11-point numerical rating scale; 0 indicating 'no pain' and 10 indicating 'worst pain imaginable'. Patients who had numerical rating scale scores of more than 0 were further evaluated with regard to the impact of pain on their daily activities.

RESULTS

When compared with the placebo group, the gabapentin group displayed significantly lower visual analogue scale scores (lying and sitting) and total tramadol consumption at 8, 12, 16, 20 and 24 h after surgery (P<0.05) and higher postoperative patient satisfaction scores (P<0.05). Numerical rating scale scores at 1, 3 and 6 months after surgery were lower in the gabapentin group than in the placebo group (P<0.05). The number of patients whose daily activities were adversely affected by pain was smaller in the gabapentin group at the first month; however, the two groups were found to be similar at 3 and 6 months.

CONCLUSION

We conclude that preoperative single-dose gabapentin decreases the intensity of acute postoperative pain, tramadol consumption and the incidence and intensity of pain in the first 6 months after inguinal herniorrhaphy.

Authors+Show Affiliations

Department of Anaesthesia and Reanimation, Gülhane Military Medical Academy Haydarpaşa Training Hospital, Istanbul, Turkey. drhuseyinsen@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19424073

Citation

Sen, Hüseyin, et al. "The Effects of Gabapentin On Acute and Chronic Pain After Inguinal Herniorrhaphy." European Journal of Anaesthesiology, vol. 26, no. 9, 2009, pp. 772-6.
Sen H, Sizlan A, Yanarateş O, et al. The effects of gabapentin on acute and chronic pain after inguinal herniorrhaphy. Eur J Anaesthesiol. 2009;26(9):772-6.
Sen, H., Sizlan, A., Yanarateş, O., Senol, M. G., Inangil, G., Sücüllü, I., Ozkan, S., & Dağli, G. (2009). The effects of gabapentin on acute and chronic pain after inguinal herniorrhaphy. European Journal of Anaesthesiology, 26(9), 772-6. https://doi.org/10.1097/EJA.0b013e32832ad2fa
Sen H, et al. The Effects of Gabapentin On Acute and Chronic Pain After Inguinal Herniorrhaphy. Eur J Anaesthesiol. 2009;26(9):772-6. PubMed PMID: 19424073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of gabapentin on acute and chronic pain after inguinal herniorrhaphy. AU - Sen,Hüseyin, AU - Sizlan,Ali, AU - Yanarateş,Omer, AU - Senol,Mehmet Güney, AU - Inangil,Gökhan, AU - Sücüllü,Ilker, AU - Ozkan,Sezai, AU - Dağli,Güner, PY - 2009/5/9/entrez PY - 2009/5/9/pubmed PY - 2010/1/12/medline SP - 772 EP - 6 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 26 IS - 9 N2 - BACKGROUND AND OBJECTIVE: To find out whether preoperative gabapentin use had a favourable effect on long-term postoperative pain in patients undergoing inguinal herniorrhaphy. METHODS: Sixty male patients--aged 20-40 years--who were scheduled for unilateral inguinal herniorrhaphy under spinal anaesthesia were included in this prospective, randomized, double-blind study. The patients were randomly allocated to two groups: the gabapentin group (n=30) received single-dose 1.2 g oral gabapentin 1 h before surgery, and the placebo group received a placebo capsule instead. Spinal anaesthesia was performed with heavy bupivacaine, and all operations were performed by the same surgeon with the same technique. Postoperative analgesia was evaluated during sitting and lying with a visual analogue scale. Assessment of postoperative pain at 1, 3 and 6 months was carried out with an 11-point numerical rating scale; 0 indicating 'no pain' and 10 indicating 'worst pain imaginable'. Patients who had numerical rating scale scores of more than 0 were further evaluated with regard to the impact of pain on their daily activities. RESULTS: When compared with the placebo group, the gabapentin group displayed significantly lower visual analogue scale scores (lying and sitting) and total tramadol consumption at 8, 12, 16, 20 and 24 h after surgery (P<0.05) and higher postoperative patient satisfaction scores (P<0.05). Numerical rating scale scores at 1, 3 and 6 months after surgery were lower in the gabapentin group than in the placebo group (P<0.05). The number of patients whose daily activities were adversely affected by pain was smaller in the gabapentin group at the first month; however, the two groups were found to be similar at 3 and 6 months. CONCLUSION: We conclude that preoperative single-dose gabapentin decreases the intensity of acute postoperative pain, tramadol consumption and the incidence and intensity of pain in the first 6 months after inguinal herniorrhaphy. SN - 1365-2346 UR - https://www.unboundmedicine.com/medline/citation/19424073/The_effects_of_gabapentin_on_acute_and_chronic_pain_after_inguinal_herniorrhaphy_ L2 - https://doi.org/10.1097/EJA.0b013e32832ad2fa DB - PRIME DP - Unbound Medicine ER -