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Effects of sodium fluoride exposure on some biochemical parameters in mice: evaluation of the ameliorative effect of royal jelly applications on these parameters.
Food Chem Toxicol 2009; 47(6):1184-9FC

Abstract

Forty eight male Balb/c mice, each weighing 30-35 g, were used in the present study. The animals were divided into four equal groups. The first group served as the control group, and the second group was administered royal jelly at a dose of 50 mg/kg bw by gavage for a period of 7 days. The third group received 200 ppm fluoride, as sodium fluoride, for a period of 7 days, in drinking water. Lastly, the fourth group was given 200 ppm fluoride in drinking water, in association with royal jelly at a dose of 50 mg/kg bw by gavage, for a period of 7 days. At the end of the seventh day, blood samples were collected from all groups into heparinised and dry tubes, and liver samples were taken concurrently. Erythrocyte and liver tissue malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities were evaluated in the blood and tissue samples obtained. Furthermore, serum cholesterol, triglyceride, glucose, total protein and albumin levels, and aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alcaline phosphatase (ALP) activities were evaluated. In conclusion, fluoride was determined to cause adverse effects in mice, and the administration of royal jelly to these animals alleviated the adverse effects of fluoride.

Authors+Show Affiliations

University of Erciyes, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Kayseri, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19425189

Citation

Kanbur, Murat, et al. "Effects of Sodium Fluoride Exposure On some Biochemical Parameters in Mice: Evaluation of the Ameliorative Effect of Royal Jelly Applications On These Parameters." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 6, 2009, pp. 1184-9.
Kanbur M, Eraslan G, Silici S, et al. Effects of sodium fluoride exposure on some biochemical parameters in mice: evaluation of the ameliorative effect of royal jelly applications on these parameters. Food Chem Toxicol. 2009;47(6):1184-9.
Kanbur, M., Eraslan, G., Silici, S., & Karabacak, M. (2009). Effects of sodium fluoride exposure on some biochemical parameters in mice: evaluation of the ameliorative effect of royal jelly applications on these parameters. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(6), pp. 1184-9. doi:10.1016/j.fct.2009.02.008.
Kanbur M, et al. Effects of Sodium Fluoride Exposure On some Biochemical Parameters in Mice: Evaluation of the Ameliorative Effect of Royal Jelly Applications On These Parameters. Food Chem Toxicol. 2009;47(6):1184-9. PubMed PMID: 19425189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of sodium fluoride exposure on some biochemical parameters in mice: evaluation of the ameliorative effect of royal jelly applications on these parameters. AU - Kanbur,Murat, AU - Eraslan,Gökhan, AU - Silici,Sibel, AU - Karabacak,Mürsel, PY - 2009/5/9/entrez PY - 2009/5/9/pubmed PY - 2009/7/17/medline SP - 1184 EP - 9 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 47 IS - 6 N2 - Forty eight male Balb/c mice, each weighing 30-35 g, were used in the present study. The animals were divided into four equal groups. The first group served as the control group, and the second group was administered royal jelly at a dose of 50 mg/kg bw by gavage for a period of 7 days. The third group received 200 ppm fluoride, as sodium fluoride, for a period of 7 days, in drinking water. Lastly, the fourth group was given 200 ppm fluoride in drinking water, in association with royal jelly at a dose of 50 mg/kg bw by gavage, for a period of 7 days. At the end of the seventh day, blood samples were collected from all groups into heparinised and dry tubes, and liver samples were taken concurrently. Erythrocyte and liver tissue malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities were evaluated in the blood and tissue samples obtained. Furthermore, serum cholesterol, triglyceride, glucose, total protein and albumin levels, and aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alcaline phosphatase (ALP) activities were evaluated. In conclusion, fluoride was determined to cause adverse effects in mice, and the administration of royal jelly to these animals alleviated the adverse effects of fluoride. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19425189/Effects_of_sodium_fluoride_exposure_on_some_biochemical_parameters_in_mice:_evaluation_of_the_ameliorative_effect_of_royal_jelly_applications_on_these_parameters_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00074-X DB - PRIME DP - Unbound Medicine ER -