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Propolis alleviates aluminium-induced lipid peroxidation and biochemical parameters in male rats.

Abstract

Aluminium is present in many manufactured foods and medicines and is also added to drinking water during purification purposes. Therefore, the present experiment was undertaken to determine the effectiveness of propolis in alleviating the toxicity of aluminium chloride (AlCl3) on biochemical parameters, antioxidant enzymes and lipid peroxidation of male Wistar Albino rats. Animals were assigned to 1 of 4 groups: control; 34 mg AlCl3/kg bw; 50 mg propolis/kg bw; AlCl3 (34 mg/kg bw) plus propolis (50 mg/kg bw), respectively. Rats were orally administered their respective doses daily for 70 days. The levels of thiobarbituric acid reactive substances (TBARS) was increased, and the activities of glutathione S-transferase, superoxide dismutase, catalase and glutathione peroxidase were decreased in liver, kidney and brain of rats treated with AlCl3. While, TBARS was decreased and the antioxidant enzymes were increased in rats treated with propolis alone. Plasma transaminases, lactate dehydrogenase, glucose, urea, creatinine, bilirubin, total lipid, cholesterol, triglyceride and LDL-c were increased, while total protein, albumin and high HDL-c were decreased due to AlCl3 administration. The presence of propolis with AlCl3 alleviated its toxic effects in rats treated with AlCl3. It can be concluded that propolis has beneficial influences and could be able to antagonize AlCl3 toxicity.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.

    , ,

    Source

    MeSH

    Aluminum Compounds
    Animals
    Antioxidants
    Brain
    Chlorides
    Free Radicals
    Kidney
    Lipid Peroxidation
    Liver
    Liver Function Tests
    Male
    Propolis
    Rats
    Thiobarbituric Acid Reactive Substances
    Tissue Distribution

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19425229

    Citation

    TY - JOUR T1 - Propolis alleviates aluminium-induced lipid peroxidation and biochemical parameters in male rats. AU - Newairy,Al-Sayeda A, AU - Salama,Afrah F, AU - Hussien,Hend M, AU - Yousef,Mokhtar I, PY - 2009/5/9/entrez PY - 2009/5/9/pubmed PY - 2009/7/17/medline SP - 1093 EP - 8 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 47 IS - 6 N2 - Aluminium is present in many manufactured foods and medicines and is also added to drinking water during purification purposes. Therefore, the present experiment was undertaken to determine the effectiveness of propolis in alleviating the toxicity of aluminium chloride (AlCl3) on biochemical parameters, antioxidant enzymes and lipid peroxidation of male Wistar Albino rats. Animals were assigned to 1 of 4 groups: control; 34 mg AlCl3/kg bw; 50 mg propolis/kg bw; AlCl3 (34 mg/kg bw) plus propolis (50 mg/kg bw), respectively. Rats were orally administered their respective doses daily for 70 days. The levels of thiobarbituric acid reactive substances (TBARS) was increased, and the activities of glutathione S-transferase, superoxide dismutase, catalase and glutathione peroxidase were decreased in liver, kidney and brain of rats treated with AlCl3. While, TBARS was decreased and the antioxidant enzymes were increased in rats treated with propolis alone. Plasma transaminases, lactate dehydrogenase, glucose, urea, creatinine, bilirubin, total lipid, cholesterol, triglyceride and LDL-c were increased, while total protein, albumin and high HDL-c were decreased due to AlCl3 administration. The presence of propolis with AlCl3 alleviated its toxic effects in rats treated with AlCl3. It can be concluded that propolis has beneficial influences and could be able to antagonize AlCl3 toxicity. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19425229/Propolis_alleviates_aluminium_induced_lipid_peroxidation_and_biochemical_parameters_in_male_rats_ L2 - http://find.galegroup.com/openurl/openurl?url_ver=Z39.88-2004&url_ctx_fmt=info:ofi/fmt:kev:mtx:ctx&req_dat=info:sid/gale:ugnid:&res_id=info:sid/gale:AONE&ctx_enc=info:ofi:enc:UTF-8&rft_val_fmt=info:ofi/fmt:kev:mtx:&rft.spage=1093&rft.volume=47&rft.issue=6&rft.issn=0278-6915&rft.date=2009 ER -