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Preparation of ionic liquid based solid-phase microextraction fiber and its application to forensic determination of methamphetamine and amphetamine in human urine.
J Chromatogr A. 2009 Jun 12; 1216(24):4824-30.JC

Abstract

A new solid-phase microextraction (SPME) procedure using an ionic liquid (IL) has been developed. Reusable IL-based SPME fiber was prepared for the first time by fixing IL through cross-linkage of IL impregnated silicone elastomer on the surface of a fused silica fiber. 1-Ethoxyethyl-3-methylimidazloium bis(trifluoromethane) sulfonylimide ([EeMim][NTf(2)]) ionic liquid was employed as a demonstration and the prepared fiber was applied to the forensic headspace determination of methamphetamine (MAP) and amphetamine (AP) in human urine samples. Important extraction parameters including the concentration of salt and base in sample matrix, extraction temperature and extraction time were investigated and optimized. Combined with gas chromatography/mass spectrometry (GC/MS) working in selected ion monitoring (SIM) mode, the new method showed good linearity in the range of 20-1500 microg L(-1), good repeatability (RSD<7.5% for MAP, and <11.5% for AP, n=6), and low detection limits (0.1 microg L(-1) for MAP and 0.5 microg L(-1) for AP). Feasibility of the method was evaluated by analyzing human urine samples. Although IL-based SPME is still at the beginning of its development stage, the results obtained by this work showed that it is a promising simple, fast and sensitive sample preparation method.

Authors+Show Affiliations

Department of Sciences, John Jay College of Criminal Justice, The City University of New York, 445 West 59th Street, New York, NY 10019, USA. yhe@jjay.cuny.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19426983

Citation

He, Yi, et al. "Preparation of Ionic Liquid Based Solid-phase Microextraction Fiber and Its Application to Forensic Determination of Methamphetamine and Amphetamine in Human Urine." Journal of Chromatography. A, vol. 1216, no. 24, 2009, pp. 4824-30.
He Y, Pohl J, Engel R, et al. Preparation of ionic liquid based solid-phase microextraction fiber and its application to forensic determination of methamphetamine and amphetamine in human urine. J Chromatogr A. 2009;1216(24):4824-30.
He, Y., Pohl, J., Engel, R., Rothman, L., & Thomas, M. (2009). Preparation of ionic liquid based solid-phase microextraction fiber and its application to forensic determination of methamphetamine and amphetamine in human urine. Journal of Chromatography. A, 1216(24), 4824-30. https://doi.org/10.1016/j.chroma.2009.04.028
He Y, et al. Preparation of Ionic Liquid Based Solid-phase Microextraction Fiber and Its Application to Forensic Determination of Methamphetamine and Amphetamine in Human Urine. J Chromatogr A. 2009 Jun 12;1216(24):4824-30. PubMed PMID: 19426983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation of ionic liquid based solid-phase microextraction fiber and its application to forensic determination of methamphetamine and amphetamine in human urine. AU - He,Yi, AU - Pohl,Jeremy, AU - Engel,Robert, AU - Rothman,Leah, AU - Thomas,Marie, Y1 - 2009/04/16/ PY - 2009/02/12/received PY - 2009/04/08/revised PY - 2009/04/10/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/7/2/medline SP - 4824 EP - 30 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1216 IS - 24 N2 - A new solid-phase microextraction (SPME) procedure using an ionic liquid (IL) has been developed. Reusable IL-based SPME fiber was prepared for the first time by fixing IL through cross-linkage of IL impregnated silicone elastomer on the surface of a fused silica fiber. 1-Ethoxyethyl-3-methylimidazloium bis(trifluoromethane) sulfonylimide ([EeMim][NTf(2)]) ionic liquid was employed as a demonstration and the prepared fiber was applied to the forensic headspace determination of methamphetamine (MAP) and amphetamine (AP) in human urine samples. Important extraction parameters including the concentration of salt and base in sample matrix, extraction temperature and extraction time were investigated and optimized. Combined with gas chromatography/mass spectrometry (GC/MS) working in selected ion monitoring (SIM) mode, the new method showed good linearity in the range of 20-1500 microg L(-1), good repeatability (RSD<7.5% for MAP, and <11.5% for AP, n=6), and low detection limits (0.1 microg L(-1) for MAP and 0.5 microg L(-1) for AP). Feasibility of the method was evaluated by analyzing human urine samples. Although IL-based SPME is still at the beginning of its development stage, the results obtained by this work showed that it is a promising simple, fast and sensitive sample preparation method. SN - 1873-3778 UR - https://www.unboundmedicine.com/medline/citation/19426983/Preparation_of_ionic_liquid_based_solid_phase_microextraction_fiber_and_its_application_to_forensic_determination_of_methamphetamine_and_amphetamine_in_human_urine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(09)00566-4 DB - PRIME DP - Unbound Medicine ER -