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Risk factors in development of motor complications in Chinese patients with idiopathic Parkinson's disease.
J Clin Neurosci. 2009 Aug; 16(8):1034-7.JC

Abstract

Motor complications induced by levodopa (L-dopa) treatment in Parkinson's disease (PD) are not well documented in patients of Chinese ethnicity. We performed a cross-sectional study to investigate the prevalence of dyskinesias and motor fluctuations, and the factors determining their development, in a population of Chinese patients with PD. Among 137 patients with PD, 98 (71.5%) had received a L-dopa preparation. Motor fluctuations were found in 74.5% and dyskinesias in 77.6% of the 98 patients. Patients with dyskinesias were younger at onset of disease than those without. Patients with dyskinesias and motor fluctuations had significantly longer duration of PD and L-dopa treatment, higher daily doses of L-dopa, and higher scores in the 39-item Parkinson's Disease Questionnaire (PDQ-39), when compared to patients without motor complications. Among these factors, motor fluctuations were best predicted by duration of L-dopa treatment and dyskinesias by disease duration. We conclude that motor complications are closely related to disease and treatment parameters, especially the treatment and disease duration.

Authors+Show Affiliations

Hong Kong Baptist University, Kowloon Tong, Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19428256

Citation

Kum, Wan Fung, et al. "Risk Factors in Development of Motor Complications in Chinese Patients With Idiopathic Parkinson's Disease." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 16, no. 8, 2009, pp. 1034-7.
Kum WF, Gao J, Durairajan SS, et al. Risk factors in development of motor complications in Chinese patients with idiopathic Parkinson's disease. J Clin Neurosci. 2009;16(8):1034-7.
Kum, W. F., Gao, J., Durairajan, S. S., Man, S. C., Xie, L. X., Lu, J. H., Fong, W. L., & Li, M. (2009). Risk factors in development of motor complications in Chinese patients with idiopathic Parkinson's disease. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 16(8), 1034-7. https://doi.org/10.1016/j.jocn.2008.10.015
Kum WF, et al. Risk Factors in Development of Motor Complications in Chinese Patients With Idiopathic Parkinson's Disease. J Clin Neurosci. 2009;16(8):1034-7. PubMed PMID: 19428256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors in development of motor complications in Chinese patients with idiopathic Parkinson's disease. AU - Kum,Wan Fung, AU - Gao,Jing, AU - Durairajan,Siva Sundara Kumar, AU - Man,Sui Cheung, AU - Xie,Li Xia, AU - Lu,Jia Hong, AU - Fong,Wai Leuk, AU - Li,Min, Y1 - 2009/05/09/ PY - 2008/05/13/received PY - 2008/08/03/revised PY - 2008/10/27/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/9/24/medline SP - 1034 EP - 7 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 16 IS - 8 N2 - Motor complications induced by levodopa (L-dopa) treatment in Parkinson's disease (PD) are not well documented in patients of Chinese ethnicity. We performed a cross-sectional study to investigate the prevalence of dyskinesias and motor fluctuations, and the factors determining their development, in a population of Chinese patients with PD. Among 137 patients with PD, 98 (71.5%) had received a L-dopa preparation. Motor fluctuations were found in 74.5% and dyskinesias in 77.6% of the 98 patients. Patients with dyskinesias were younger at onset of disease than those without. Patients with dyskinesias and motor fluctuations had significantly longer duration of PD and L-dopa treatment, higher daily doses of L-dopa, and higher scores in the 39-item Parkinson's Disease Questionnaire (PDQ-39), when compared to patients without motor complications. Among these factors, motor fluctuations were best predicted by duration of L-dopa treatment and dyskinesias by disease duration. We conclude that motor complications are closely related to disease and treatment parameters, especially the treatment and disease duration. SN - 0967-5868 UR - https://www.unboundmedicine.com/medline/citation/19428256/Risk_factors_in_development_of_motor_complications_in_Chinese_patients_with_idiopathic_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(08)00611-5 DB - PRIME DP - Unbound Medicine ER -