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Oxidative damage to proteins and DNA in rats exposed to cadmium and/or ethanol.
Chem Biol Interact. 2009 Jun 15; 180(1):31-8.CB

Abstract

The study was aimed to estimate whether rat's exposure to cadmium (Cd; 50mg/l in drinking water for 12 weeks) and/or ethanol (EtOH; 5g/kg b.wt./24h p.o. for 12 weeks), noted by us to induce oxidative stress and stimulate lipid peroxidation, can cause oxidative damage to proteins and DNA, and whether and to what extent the effects of co-exposure differ from those observed under the treatment with each substance alone. Protein carbonyl groups (PC) and protein thiol groups (PSH) in the serum, liver and kidney, as markers of oxidative protein damage, and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the serum, as a marker of DNA oxidation, were determined. The exposure to Cd or/and EtOH led to oxidative protein damage (increased PC and decreased PSH concentrations in the serum and/or liver), and to DNA oxidation (increased 8-OHdG concentration in the serum). The effects were more advanced at the co-exposure than at the treatment with each substance alone. The more serious damage to proteins and DNA at the co-exposure to Cd and EtOH seems to be the effect of independent action of both xenobiotics. The results of the present paper together with our recent findings in the same rats seem to indicate that at co-exposure to Cd and EtOH proteins and DNA may be more vulnerable to oxidation than lipids. The paper is the first report suggesting that excessive EtOH consumption during exposure to Cd may increase the risk of health damage via enhancing protein and DNA oxidation.

Authors+Show Affiliations

Department of Toxicology, Medical University of Białystok, Białystok, Poland. Malgorzata.Galazyn-Sidorczuk@umwb.edu.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19428343

Citation

Gałazyn-Sidorczuk, Małgorzata, et al. "Oxidative Damage to Proteins and DNA in Rats Exposed to Cadmium And/or Ethanol." Chemico-biological Interactions, vol. 180, no. 1, 2009, pp. 31-8.
Gałazyn-Sidorczuk M, Brzóska MM, Jurczuk M, et al. Oxidative damage to proteins and DNA in rats exposed to cadmium and/or ethanol. Chem Biol Interact. 2009;180(1):31-8.
Gałazyn-Sidorczuk, M., Brzóska, M. M., Jurczuk, M., & Moniuszko-Jakoniuk, J. (2009). Oxidative damage to proteins and DNA in rats exposed to cadmium and/or ethanol. Chemico-biological Interactions, 180(1), 31-8. https://doi.org/10.1016/j.cbi.2009.01.014
Gałazyn-Sidorczuk M, et al. Oxidative Damage to Proteins and DNA in Rats Exposed to Cadmium And/or Ethanol. Chem Biol Interact. 2009 Jun 15;180(1):31-8. PubMed PMID: 19428343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative damage to proteins and DNA in rats exposed to cadmium and/or ethanol. AU - Gałazyn-Sidorczuk,Małgorzata, AU - Brzóska,Małgorzata M, AU - Jurczuk,Maria, AU - Moniuszko-Jakoniuk,Janina, Y1 - 2009/02/10/ PY - 2008/11/07/received PY - 2009/01/29/revised PY - 2009/01/30/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/6/3/medline SP - 31 EP - 8 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 180 IS - 1 N2 - The study was aimed to estimate whether rat's exposure to cadmium (Cd; 50mg/l in drinking water for 12 weeks) and/or ethanol (EtOH; 5g/kg b.wt./24h p.o. for 12 weeks), noted by us to induce oxidative stress and stimulate lipid peroxidation, can cause oxidative damage to proteins and DNA, and whether and to what extent the effects of co-exposure differ from those observed under the treatment with each substance alone. Protein carbonyl groups (PC) and protein thiol groups (PSH) in the serum, liver and kidney, as markers of oxidative protein damage, and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the serum, as a marker of DNA oxidation, were determined. The exposure to Cd or/and EtOH led to oxidative protein damage (increased PC and decreased PSH concentrations in the serum and/or liver), and to DNA oxidation (increased 8-OHdG concentration in the serum). The effects were more advanced at the co-exposure than at the treatment with each substance alone. The more serious damage to proteins and DNA at the co-exposure to Cd and EtOH seems to be the effect of independent action of both xenobiotics. The results of the present paper together with our recent findings in the same rats seem to indicate that at co-exposure to Cd and EtOH proteins and DNA may be more vulnerable to oxidation than lipids. The paper is the first report suggesting that excessive EtOH consumption during exposure to Cd may increase the risk of health damage via enhancing protein and DNA oxidation. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/19428343/Oxidative_damage_to_proteins_and_DNA_in_rats_exposed_to_cadmium_and/or_ethanol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(09)00069-6 DB - PRIME DP - Unbound Medicine ER -