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Biodegradable and biocompatible multi-arm star amphiphilic block copolymer as a carrier for hydrophobic drug delivery.
Int J Biol Macromol 2009; 44(4):346-52IJ

Abstract

Multi-arm star amphiphilic block copolymers (SABCs) with approximately 32 arms were synthesized and characterized for drug delivery applications. A hyperbranched polyester, boltorn H40 (H40), was used as the macroinitiator for the ring-opening polymerization of epsilon-caprolactone (epsilon-CL). The resulting multi-arm H40-poly(epsilon-caprolactone) (H40-PCL-OH) was further reacted with carboxyl terminated methoxy poly(ethylene glycol) (MPEG-COOH) to form H40-PCL-b-MPEG copolymers. The resulting SABCs were characterized by (1)H NMR spectroscopy and gel permeation chromatography (GPC). The critical aggregation concentration (CAC) of H40-PCL-b-MPEG was 3.8 mg/L as determined by fluorescence spectrophotometry. Below the CAC, stable unimolecular micelles were formed with an average diameter of 18 nm as measured by TEM. Above the CAC, unimolecular micelles exhibited agglomeration with an average diameter of 98 nm. The hydrodynamic diameter of these agglomerates was found to be 122 nm, as measured by dynamic light scattering (DLS). The drug loading efficacy of the H40-PCL-b-MPEG micelles was 26 wt%. Drug release study showed an initial burst followed by a sustained release of the entrapped hydrophobic model drug, 5-fluorouracil, over a period of 9-140 h. These results indicate that the H40-PCL-b-MPEG micelles have great potential as hydrophobic drug delivery carriers.

Authors+Show Affiliations

Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19428465

Citation

Aryal, Santosh, et al. "Biodegradable and Biocompatible Multi-arm Star Amphiphilic Block Copolymer as a Carrier for Hydrophobic Drug Delivery." International Journal of Biological Macromolecules, vol. 44, no. 4, 2009, pp. 346-52.
Aryal S, Prabaharan M, Pilla S, et al. Biodegradable and biocompatible multi-arm star amphiphilic block copolymer as a carrier for hydrophobic drug delivery. Int J Biol Macromol. 2009;44(4):346-52.
Aryal, S., Prabaharan, M., Pilla, S., & Gong, S. (2009). Biodegradable and biocompatible multi-arm star amphiphilic block copolymer as a carrier for hydrophobic drug delivery. International Journal of Biological Macromolecules, 44(4), pp. 346-52. doi:10.1016/j.ijbiomac.2009.01.007.
Aryal S, et al. Biodegradable and Biocompatible Multi-arm Star Amphiphilic Block Copolymer as a Carrier for Hydrophobic Drug Delivery. Int J Biol Macromol. 2009 May 1;44(4):346-52. PubMed PMID: 19428465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biodegradable and biocompatible multi-arm star amphiphilic block copolymer as a carrier for hydrophobic drug delivery. AU - Aryal,Santosh, AU - Prabaharan,Mani, AU - Pilla,Srikanth, AU - Gong,Shaoqin, Y1 - 2009/02/13/ PY - 2009/01/07/received PY - 2009/01/25/revised PY - 2009/01/29/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/7/10/medline SP - 346 EP - 52 JF - International journal of biological macromolecules JO - Int. J. Biol. Macromol. VL - 44 IS - 4 N2 - Multi-arm star amphiphilic block copolymers (SABCs) with approximately 32 arms were synthesized and characterized for drug delivery applications. A hyperbranched polyester, boltorn H40 (H40), was used as the macroinitiator for the ring-opening polymerization of epsilon-caprolactone (epsilon-CL). The resulting multi-arm H40-poly(epsilon-caprolactone) (H40-PCL-OH) was further reacted with carboxyl terminated methoxy poly(ethylene glycol) (MPEG-COOH) to form H40-PCL-b-MPEG copolymers. The resulting SABCs were characterized by (1)H NMR spectroscopy and gel permeation chromatography (GPC). The critical aggregation concentration (CAC) of H40-PCL-b-MPEG was 3.8 mg/L as determined by fluorescence spectrophotometry. Below the CAC, stable unimolecular micelles were formed with an average diameter of 18 nm as measured by TEM. Above the CAC, unimolecular micelles exhibited agglomeration with an average diameter of 98 nm. The hydrodynamic diameter of these agglomerates was found to be 122 nm, as measured by dynamic light scattering (DLS). The drug loading efficacy of the H40-PCL-b-MPEG micelles was 26 wt%. Drug release study showed an initial burst followed by a sustained release of the entrapped hydrophobic model drug, 5-fluorouracil, over a period of 9-140 h. These results indicate that the H40-PCL-b-MPEG micelles have great potential as hydrophobic drug delivery carriers. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/19428465/Biodegradable_and_biocompatible_multi_arm_star_amphiphilic_block_copolymer_as_a_carrier_for_hydrophobic_drug_delivery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(09)00021-X DB - PRIME DP - Unbound Medicine ER -