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Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.
Behav Brain Res 2009; 201(1):120-7BB

Abstract

The APPswe/PS1dE9 mouse is a double transgenic model of Alzheimer's disease, which harbors mutant mouse/human amyloid precursor protein (Swedish K594N/M595L) and presenilin-1 genes (PS1-dE9). These mice develop beta-amyloid plaques and exhibit visuo-spatial learning and memory impairment in the Morris water maze (MWM) at 8-12 and 16-18 months of age. To extend these findings, we tested visuo-spatial learning and memory of male and female APPswe/PS1dE9 mice at 16 months of age on the Barnes maze. APPswe/PS1dE9 mice showed impaired acquisition learning using measures of latency, distance traveled, errors and hole deviation scores, and were less likely to use the spatial search strategy to locate the escape hole than wild-type mice. APPswe/PS1dE9 mice also showed a deficit in memory in probe tests on the Barnes maze relative to wild-type mice. Learning and memory deficits, however, were not found during reversal training and reversal probe tests. Sex differences were observed, as male APPswe/PS1dE9 mice had smaller reversal effects than male wild-type mice, but females of each genotype did not differ. Overall, these results replicate previous findings using the MWM, and indicate that APPswe/PS1dE9 mice have impaired visuo-spatial learning and memory at 16 months of age.

Authors+Show Affiliations

Psychology Department, Dalhousie University, Halifax, Nova Scotia, Canada. tpoleary@dal.caNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19428625

Citation

O'Leary, Timothy P., and Richard E. Brown. "Visuo-spatial Learning and Memory Deficits On the Barnes Maze in the 16-month-old APPswe/PS1dE9 Mouse Model of Alzheimer's Disease." Behavioural Brain Research, vol. 201, no. 1, 2009, pp. 120-7.
O'Leary TP, Brown RE. Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. Behav Brain Res. 2009;201(1):120-7.
O'Leary, T. P., & Brown, R. E. (2009). Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. Behavioural Brain Research, 201(1), pp. 120-7. doi:10.1016/j.bbr.2009.01.039.
O'Leary TP, Brown RE. Visuo-spatial Learning and Memory Deficits On the Barnes Maze in the 16-month-old APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. Behav Brain Res. 2009 Jul 19;201(1):120-7. PubMed PMID: 19428625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. AU - O'Leary,Timothy P, AU - Brown,Richard E, Y1 - 2009/02/06/ PY - 2008/12/22/received PY - 2009/01/26/revised PY - 2009/01/31/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/8/14/medline SP - 120 EP - 7 JF - Behavioural brain research JO - Behav. Brain Res. VL - 201 IS - 1 N2 - The APPswe/PS1dE9 mouse is a double transgenic model of Alzheimer's disease, which harbors mutant mouse/human amyloid precursor protein (Swedish K594N/M595L) and presenilin-1 genes (PS1-dE9). These mice develop beta-amyloid plaques and exhibit visuo-spatial learning and memory impairment in the Morris water maze (MWM) at 8-12 and 16-18 months of age. To extend these findings, we tested visuo-spatial learning and memory of male and female APPswe/PS1dE9 mice at 16 months of age on the Barnes maze. APPswe/PS1dE9 mice showed impaired acquisition learning using measures of latency, distance traveled, errors and hole deviation scores, and were less likely to use the spatial search strategy to locate the escape hole than wild-type mice. APPswe/PS1dE9 mice also showed a deficit in memory in probe tests on the Barnes maze relative to wild-type mice. Learning and memory deficits, however, were not found during reversal training and reversal probe tests. Sex differences were observed, as male APPswe/PS1dE9 mice had smaller reversal effects than male wild-type mice, but females of each genotype did not differ. Overall, these results replicate previous findings using the MWM, and indicate that APPswe/PS1dE9 mice have impaired visuo-spatial learning and memory at 16 months of age. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/19428625/Visuo_spatial_learning_and_memory_deficits_on_the_Barnes_maze_in_the_16_month_old_APPswe/PS1dE9_mouse_model_of_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(09)00079-5 DB - PRIME DP - Unbound Medicine ER -