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Phylogenetic and biological characterization of highly pathogenic H5N1 avian influenza viruses (Vietnam 2005) in chickens and ducks.
Virus Res. 2009 Jun; 142(1-2):108-20.VR

Abstract

Analysis of Asian H5N1 avian influenza (AI) virus hemagglutinin (HA) genes shows a common origin, but the virus has evolved into at least three major clades (clades 0, 1, and 2) over the last 13 years. Previous reports of Vietnam viruses have documented predominantly clade 1 viruses. Unexpectedly, 19 viruses from northern Vietnam isolated in December 2005 fell into clade 2. These viruses further clustered into two distinct sublineages. Representative viruses from each sublineage were chosen for antigenic and pathogenic evaluation. Two distinct antigenic groups correlating with the genetic information were present when comparing hemagglutination inhibition (HI) titers. All viruses were highly virulent not only in chickens, killing them within 2 days of experimental inoculation, but also in 2- and 5-week-old Pekin ducks, causing 100% mortality within 4 days of challenge. The information gained about these viruses provides insight with regards to implementing control programs, including vaccine seed strain selection.

Authors+Show Affiliations

Southeast Poultry Research Laboratory, USDA, ARS, 934 College Station Road, Athens, GA 30605, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19428743

Citation

Pfeiffer, J, et al. "Phylogenetic and Biological Characterization of Highly Pathogenic H5N1 Avian Influenza Viruses (Vietnam 2005) in Chickens and Ducks." Virus Research, vol. 142, no. 1-2, 2009, pp. 108-20.
Pfeiffer J, Pantin-Jackwood M, To TL, et al. Phylogenetic and biological characterization of highly pathogenic H5N1 avian influenza viruses (Vietnam 2005) in chickens and ducks. Virus Res. 2009;142(1-2):108-20.
Pfeiffer, J., Pantin-Jackwood, M., To, T. L., Nguyen, T., & Suarez, D. L. (2009). Phylogenetic and biological characterization of highly pathogenic H5N1 avian influenza viruses (Vietnam 2005) in chickens and ducks. Virus Research, 142(1-2), 108-20. https://doi.org/10.1016/j.virusres.2009.01.019
Pfeiffer J, et al. Phylogenetic and Biological Characterization of Highly Pathogenic H5N1 Avian Influenza Viruses (Vietnam 2005) in Chickens and Ducks. Virus Res. 2009;142(1-2):108-20. PubMed PMID: 19428743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phylogenetic and biological characterization of highly pathogenic H5N1 avian influenza viruses (Vietnam 2005) in chickens and ducks. AU - Pfeiffer,J, AU - Pantin-Jackwood,M, AU - To,T L, AU - Nguyen,T, AU - Suarez,D L, Y1 - 2009/02/10/ PY - 2008/12/02/received PY - 2009/01/25/revised PY - 2009/01/26/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/7/2/medline SP - 108 EP - 20 JF - Virus research JO - Virus Res VL - 142 IS - 1-2 N2 - Analysis of Asian H5N1 avian influenza (AI) virus hemagglutinin (HA) genes shows a common origin, but the virus has evolved into at least three major clades (clades 0, 1, and 2) over the last 13 years. Previous reports of Vietnam viruses have documented predominantly clade 1 viruses. Unexpectedly, 19 viruses from northern Vietnam isolated in December 2005 fell into clade 2. These viruses further clustered into two distinct sublineages. Representative viruses from each sublineage were chosen for antigenic and pathogenic evaluation. Two distinct antigenic groups correlating with the genetic information were present when comparing hemagglutination inhibition (HI) titers. All viruses were highly virulent not only in chickens, killing them within 2 days of experimental inoculation, but also in 2- and 5-week-old Pekin ducks, causing 100% mortality within 4 days of challenge. The information gained about these viruses provides insight with regards to implementing control programs, including vaccine seed strain selection. SN - 0168-1702 UR - https://www.unboundmedicine.com/medline/citation/19428743/Phylogenetic_and_biological_characterization_of_highly_pathogenic_H5N1_avian_influenza_viruses__Vietnam_2005__in_chickens_and_ducks_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(09)00041-0 DB - PRIME DP - Unbound Medicine ER -