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RNA secondary structures in the proximal 3'UTR of Indonesian Dengue 1 virus strains.
Virus Res. 2009 Jun; 142(1-2):213-6.VR

Abstract

The characteristics of DENV-1 viruses, isolated during the 2001-2002 outbreak in Indonesia were studied. The secondary structure of the 3'UTR of different DENV-1 strains derived from Indonesian patients was compared with the 3'UTR of previously described DENV-1 sequences. The complete 3'UTR of DENV-1 was sequenced from 13 patients suffering from the severe form of dengue virus infection (dengue hemorrhagic fever). Prediction of RNA secondary structure of the 3'UTR revealed some previously unidentified conserved structures in the proximal region of the 3'UTR, the role of which in viral replication is still unknown. In addition our data suggest that some structural elements previously described in the distal part of the 3'UTR are partly dependent on the proximal part of the UTR. Our data support the existence of previously unidentified conserved secondary structures in the proximal part of the 3'UTR and their roles need to be further investigated.

Authors+Show Affiliations

Department of Virology, Erasmus Medical Center, s'Gravendijkwal 230, 3015CE Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19428756

Citation

Koraka, Penelope, et al. "RNA Secondary Structures in the Proximal 3'UTR of Indonesian Dengue 1 Virus Strains." Virus Research, vol. 142, no. 1-2, 2009, pp. 213-6.
Koraka P, Williams MM, Djamiatun K, et al. RNA secondary structures in the proximal 3'UTR of Indonesian Dengue 1 virus strains. Virus Res. 2009;142(1-2):213-6.
Koraka, P., Williams, M. M., Djamiatun, K., Setiati, T. E., van Batenburg, F. H., Stittelaar, K. J., Osterhaus, A. D., & Martina, B. E. (2009). RNA secondary structures in the proximal 3'UTR of Indonesian Dengue 1 virus strains. Virus Research, 142(1-2), 213-6. https://doi.org/10.1016/j.virusres.2009.02.016
Koraka P, et al. RNA Secondary Structures in the Proximal 3'UTR of Indonesian Dengue 1 Virus Strains. Virus Res. 2009;142(1-2):213-6. PubMed PMID: 19428756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - RNA secondary structures in the proximal 3'UTR of Indonesian Dengue 1 virus strains. AU - Koraka,Penelope, AU - Williams,Marisol M, AU - Djamiatun,Kis, AU - Setiati,Tatty E, AU - van Batenburg,F H D, AU - Stittelaar,Koert J, AU - Osterhaus,Albert D M E, AU - Martina,Byron E E, Y1 - 2009/03/13/ PY - 2008/12/16/received PY - 2009/02/19/revised PY - 2009/02/25/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/7/2/medline SP - 213 EP - 6 JF - Virus research JO - Virus Res VL - 142 IS - 1-2 N2 - The characteristics of DENV-1 viruses, isolated during the 2001-2002 outbreak in Indonesia were studied. The secondary structure of the 3'UTR of different DENV-1 strains derived from Indonesian patients was compared with the 3'UTR of previously described DENV-1 sequences. The complete 3'UTR of DENV-1 was sequenced from 13 patients suffering from the severe form of dengue virus infection (dengue hemorrhagic fever). Prediction of RNA secondary structure of the 3'UTR revealed some previously unidentified conserved structures in the proximal region of the 3'UTR, the role of which in viral replication is still unknown. In addition our data suggest that some structural elements previously described in the distal part of the 3'UTR are partly dependent on the proximal part of the UTR. Our data support the existence of previously unidentified conserved secondary structures in the proximal part of the 3'UTR and their roles need to be further investigated. SN - 0168-1702 UR - https://www.unboundmedicine.com/medline/citation/19428756/RNA_secondary_structures_in_the_proximal_3'UTR_of_Indonesian_Dengue_1_virus_strains_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(09)00092-6 DB - PRIME DP - Unbound Medicine ER -