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Characterization of possible correlates of protective response against Brucella ovis infection in rams immunized with the B. melitensis Rev 1 vaccine.
Vaccine. 2009 May 18; 27(23):3039-44.V

Abstract

Vaccination with the live attenuated Brucella melitensis Rev 1 vaccine is used to control ovine brucellosis caused by Brucella ovis in sheep. The objective of this study was to identify possible correlates of protective response to B. ovis infection through the characterization by microarray hybridization and real-time RT-PCR of inflammatory and immune response genes differentially expressed in rams previously immunized with B. melitensis Rev 1 and experimentally challenged with B. ovis. Gene expression profiles were compared before and after challenge with B. ovis between rams protected and those vaccinated but found infected after challenge. The TLR10, Bak and ANXI genes were expressed at higher levels in vaccinated and protected rams. These genes provide possible correlates of protective response to B. ovis infection in rams immunized with the B. melitensis Rev 1 vaccine.

Authors+Show Affiliations

Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ciudad Real, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19428917

Citation

Galindo, Ruth C., et al. "Characterization of Possible Correlates of Protective Response Against Brucella Ovis Infection in Rams Immunized With the B. Melitensis Rev 1 Vaccine." Vaccine, vol. 27, no. 23, 2009, pp. 3039-44.
Galindo RC, Muñoz PM, de Miguel MJ, et al. Characterization of possible correlates of protective response against Brucella ovis infection in rams immunized with the B. melitensis Rev 1 vaccine. Vaccine. 2009;27(23):3039-44.
Galindo, R. C., Muñoz, P. M., de Miguel, M. J., Marin, C. M., Blasco, J. M., Gortazar, C., Kocan, K. M., & de la Fuente, J. (2009). Characterization of possible correlates of protective response against Brucella ovis infection in rams immunized with the B. melitensis Rev 1 vaccine. Vaccine, 27(23), 3039-44. https://doi.org/10.1016/j.vaccine.2009.03.046
Galindo RC, et al. Characterization of Possible Correlates of Protective Response Against Brucella Ovis Infection in Rams Immunized With the B. Melitensis Rev 1 Vaccine. Vaccine. 2009 May 18;27(23):3039-44. PubMed PMID: 19428917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of possible correlates of protective response against Brucella ovis infection in rams immunized with the B. melitensis Rev 1 vaccine. AU - Galindo,Ruth C, AU - Muñoz,Pilar M, AU - de Miguel,María J, AU - Marin,Clara M, AU - Blasco,José M, AU - Gortazar,Christian, AU - Kocan,Katherine M, AU - de la Fuente,José, Y1 - 2009/04/07/ PY - 2008/10/15/received PY - 2009/03/11/revised PY - 2009/03/17/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/7/1/medline SP - 3039 EP - 44 JF - Vaccine JO - Vaccine VL - 27 IS - 23 N2 - Vaccination with the live attenuated Brucella melitensis Rev 1 vaccine is used to control ovine brucellosis caused by Brucella ovis in sheep. The objective of this study was to identify possible correlates of protective response to B. ovis infection through the characterization by microarray hybridization and real-time RT-PCR of inflammatory and immune response genes differentially expressed in rams previously immunized with B. melitensis Rev 1 and experimentally challenged with B. ovis. Gene expression profiles were compared before and after challenge with B. ovis between rams protected and those vaccinated but found infected after challenge. The TLR10, Bak and ANXI genes were expressed at higher levels in vaccinated and protected rams. These genes provide possible correlates of protective response to B. ovis infection in rams immunized with the B. melitensis Rev 1 vaccine. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/19428917/Characterization_of_possible_correlates_of_protective_response_against_Brucella_ovis_infection_in_rams_immunized_with_the_B__melitensis_Rev_1_vaccine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(09)00466-6 DB - PRIME DP - Unbound Medicine ER -