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Ketogenic diet attenuates kainic acid-induced hippocampal cell death by decreasing AMPK/ACC pathway activity and HSP70.
Neurosci Lett. 2009 Mar 27; 453(1):49-53.NL

Abstract

The ketogenic diet (KD) prevents kainic acid (KA)-induced hippocampal cell death. There are reports that AMP-activated protein kinase (AMPK) activation regulates the intracellular signaling pathways involved in cellular survival or apoptotic cell death. In this study, we investigated the effect of the KD consumption on the expression of signaling pathway proteins AMPK and ACC, and heat shock protein (HSP) 70 in mouse hippocampus after KA treatment. Mice were fed the KD for 6 weeks and then sacrificed 48h after KA (30mg/kg) injection. The marked cell death found commonly in normal diet (ND)-fed mice treated with KA was not observed in the KD-fed KA-treated mice. Western blot analysis revealed that phosphorylation of AMPK and ACC was increased after KA treatment. However, phosphorylation of these proteins was reduced in those animals that received the KD. In addition, increased expression of HSP70 in the hippocampus of KA-treated mice was decreased in animals receiving the KD. These results indicate that the KD promotes neuroprotective effects through suppression of the AMPK cascade and that HSP70 is involved in neuronal cell death or oxidative stress.

Authors+Show Affiliations

Department of Anatomy and Neurobiology, Institute of Health Sciences, Medical Research Center for Neural Dysfunction, Gyeongsang National University, School of Medicine, 92 Chilam-dong, Jinju, Gyeongnam, 660-751, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19429014

Citation

Jeon, Byeong Tak, et al. "Ketogenic Diet Attenuates Kainic Acid-induced Hippocampal Cell Death By Decreasing AMPK/ACC Pathway Activity and HSP70." Neuroscience Letters, vol. 453, no. 1, 2009, pp. 49-53.
Jeon BT, Lee DH, Kim KH, et al. Ketogenic diet attenuates kainic acid-induced hippocampal cell death by decreasing AMPK/ACC pathway activity and HSP70. Neurosci Lett. 2009;453(1):49-53.
Jeon, B. T., Lee, D. H., Kim, K. H., Kim, H. J., Kang, S. S., Cho, G. J., Choi, W. S., & Roh, G. S. (2009). Ketogenic diet attenuates kainic acid-induced hippocampal cell death by decreasing AMPK/ACC pathway activity and HSP70. Neuroscience Letters, 453(1), 49-53. https://doi.org/10.1016/j.neulet.2009.01.068
Jeon BT, et al. Ketogenic Diet Attenuates Kainic Acid-induced Hippocampal Cell Death By Decreasing AMPK/ACC Pathway Activity and HSP70. Neurosci Lett. 2009 Mar 27;453(1):49-53. PubMed PMID: 19429014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ketogenic diet attenuates kainic acid-induced hippocampal cell death by decreasing AMPK/ACC pathway activity and HSP70. AU - Jeon,Byeong Tak, AU - Lee,Dong Hoon, AU - Kim,Kyu Hong, AU - Kim,Hyun Joon, AU - Kang,Sang Soo, AU - Cho,Gyeong Jae, AU - Choi,Wan Sung, AU - Roh,Gu Seob, Y1 - 2009/01/31/ PY - 2008/11/11/received PY - 2009/01/28/revised PY - 2009/01/28/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/8/28/medline SP - 49 EP - 53 JF - Neuroscience letters JO - Neurosci Lett VL - 453 IS - 1 N2 - The ketogenic diet (KD) prevents kainic acid (KA)-induced hippocampal cell death. There are reports that AMP-activated protein kinase (AMPK) activation regulates the intracellular signaling pathways involved in cellular survival or apoptotic cell death. In this study, we investigated the effect of the KD consumption on the expression of signaling pathway proteins AMPK and ACC, and heat shock protein (HSP) 70 in mouse hippocampus after KA treatment. Mice were fed the KD for 6 weeks and then sacrificed 48h after KA (30mg/kg) injection. The marked cell death found commonly in normal diet (ND)-fed mice treated with KA was not observed in the KD-fed KA-treated mice. Western blot analysis revealed that phosphorylation of AMPK and ACC was increased after KA treatment. However, phosphorylation of these proteins was reduced in those animals that received the KD. In addition, increased expression of HSP70 in the hippocampus of KA-treated mice was decreased in animals receiving the KD. These results indicate that the KD promotes neuroprotective effects through suppression of the AMPK cascade and that HSP70 is involved in neuronal cell death or oxidative stress. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/19429014/Ketogenic_diet_attenuates_kainic_acid_induced_hippocampal_cell_death_by_decreasing_AMPK/ACC_pathway_activity_and_HSP70_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(09)00138-4 DB - PRIME DP - Unbound Medicine ER -