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Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats.
Neurosci Lett. 2009 Mar 27; 453(1):58-61.NL

Abstract

Ghrelin, a 28-amino-acid peptide, is mainly secreted by the stomach. Evidence has shown ghrelin to have neuroprotective effects. However, whether ghrelin protects hippocampal neurons against cell death in pilocarpine-induced seizures is unknown. We used Nissl staining to show that ghrelin attenuated the neuronal loss caused by pilocarpine-induced seizures in the hippocampus. Ghrelin exerted the protective action through regulating the phosphatidylinositol-3-kinase and Akt pathway. Moreover, ghrelin treatment reversed the decreased ratio of Bcl-2 to Bax induced by seizures while inhibiting the activated caspase-3. Ghrelin can inhibit hippocampal neuronal damage caused by pilocarpine-induced seizures, which might have therapeutic value in seizures.

Authors+Show Affiliations

Department of Neurology, Qilu Hospital, Shandong University, 44#, Wenhua Xi Road, Jinan 250012, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19429016

Citation

Xu, Jingjing, et al. "Ghrelin Protects Against Cell Death of Hippocampal Neurons in Pilocarpine-induced Seizures in Rats." Neuroscience Letters, vol. 453, no. 1, 2009, pp. 58-61.
Xu J, Wang S, Lin Y, et al. Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. Neurosci Lett. 2009;453(1):58-61.
Xu, J., Wang, S., Lin, Y., Cao, L., Wang, R., & Chi, Z. (2009). Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. Neuroscience Letters, 453(1), 58-61. https://doi.org/10.1016/j.neulet.2009.01.067
Xu J, et al. Ghrelin Protects Against Cell Death of Hippocampal Neurons in Pilocarpine-induced Seizures in Rats. Neurosci Lett. 2009 Mar 27;453(1):58-61. PubMed PMID: 19429016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. AU - Xu,Jingjing, AU - Wang,Shuzhen, AU - Lin,Youting, AU - Cao,Lili, AU - Wang,Rong, AU - Chi,Zhaofu, Y1 - 2009/01/30/ PY - 2008/12/16/received PY - 2009/01/25/revised PY - 2009/01/26/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/8/28/medline SP - 58 EP - 61 JF - Neuroscience letters JO - Neurosci Lett VL - 453 IS - 1 N2 - Ghrelin, a 28-amino-acid peptide, is mainly secreted by the stomach. Evidence has shown ghrelin to have neuroprotective effects. However, whether ghrelin protects hippocampal neurons against cell death in pilocarpine-induced seizures is unknown. We used Nissl staining to show that ghrelin attenuated the neuronal loss caused by pilocarpine-induced seizures in the hippocampus. Ghrelin exerted the protective action through regulating the phosphatidylinositol-3-kinase and Akt pathway. Moreover, ghrelin treatment reversed the decreased ratio of Bcl-2 to Bax induced by seizures while inhibiting the activated caspase-3. Ghrelin can inhibit hippocampal neuronal damage caused by pilocarpine-induced seizures, which might have therapeutic value in seizures. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/19429016/Ghrelin_protects_against_cell_death_of_hippocampal_neurons_in_pilocarpine_induced_seizures_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(09)00124-4 DB - PRIME DP - Unbound Medicine ER -