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Oral administration of Uncariae rhynchophylla inhibits the development of DNFB-induced atopic dermatitis-like skin lesions via IFN-gamma down-regulation in NC/Nga mice.
J Ethnopharmacol. 2009 Apr 21; 122(3):567-72.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Uncariae rhynchophylla (UR) is an herb which has blood pressure lowering and anti-inflammatory effects and has been prescribed traditionally to treat stroke and vascular dementia.

AIM OF STUDY

In the present study, we examined whether UR suppress Atopic dermatitis (AD)-like skin lesions in NC/Nga mice treated with 2, 4-dinitrofluorobenzene (DNFB) under SPF conditions.

MATERIAL AND METHODS

The effect of UR in DNFB- treated NC/Nga mice was determined by measuring the skin symptom severity, levels of serum IgE, and of the amounts of IL-4 and IFN-gamma secreted by activated T cells in draining lymph nodes.

RESULTS

Oral administration of UR to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. IFN-gamma production by CD4+ T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by UR treatment, although levels of IL-4 and total IgE in serum were not.

CONCLUSION

UR may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-gamma production.

Authors+Show Affiliations

Department of Microbiology (BK21), College of Medicine, Kyung Hee University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19429328

Citation

Kim, Dong-Young, et al. "Oral Administration of Uncariae Rhynchophylla Inhibits the Development of DNFB-induced Atopic Dermatitis-like Skin Lesions Via IFN-gamma Down-regulation in NC/Nga Mice." Journal of Ethnopharmacology, vol. 122, no. 3, 2009, pp. 567-72.
Kim DY, Jung JA, Kim TH, et al. Oral administration of Uncariae rhynchophylla inhibits the development of DNFB-induced atopic dermatitis-like skin lesions via IFN-gamma down-regulation in NC/Nga mice. J Ethnopharmacol. 2009;122(3):567-72.
Kim, D. Y., Jung, J. A., Kim, T. H., Seo, S. W., Jung, S. K., & Park, C. S. (2009). Oral administration of Uncariae rhynchophylla inhibits the development of DNFB-induced atopic dermatitis-like skin lesions via IFN-gamma down-regulation in NC/Nga mice. Journal of Ethnopharmacology, 122(3), 567-72. https://doi.org/10.1016/j.jep.2008.12.029
Kim DY, et al. Oral Administration of Uncariae Rhynchophylla Inhibits the Development of DNFB-induced Atopic Dermatitis-like Skin Lesions Via IFN-gamma Down-regulation in NC/Nga Mice. J Ethnopharmacol. 2009 Apr 21;122(3):567-72. PubMed PMID: 19429328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral administration of Uncariae rhynchophylla inhibits the development of DNFB-induced atopic dermatitis-like skin lesions via IFN-gamma down-regulation in NC/Nga mice. AU - Kim,Dong-Young, AU - Jung,Jung-A, AU - Kim,Tae-Ho, AU - Seo,Sang-Wan, AU - Jung,Sung-Ki, AU - Park,Cheung-Seog, Y1 - 2009/02/12/ PY - 2008/06/24/received PY - 2008/11/25/revised PY - 2008/12/16/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/8/6/medline SP - 567 EP - 72 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 122 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Uncariae rhynchophylla (UR) is an herb which has blood pressure lowering and anti-inflammatory effects and has been prescribed traditionally to treat stroke and vascular dementia. AIM OF STUDY: In the present study, we examined whether UR suppress Atopic dermatitis (AD)-like skin lesions in NC/Nga mice treated with 2, 4-dinitrofluorobenzene (DNFB) under SPF conditions. MATERIAL AND METHODS: The effect of UR in DNFB- treated NC/Nga mice was determined by measuring the skin symptom severity, levels of serum IgE, and of the amounts of IL-4 and IFN-gamma secreted by activated T cells in draining lymph nodes. RESULTS: Oral administration of UR to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. IFN-gamma production by CD4+ T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by UR treatment, although levels of IL-4 and total IgE in serum were not. CONCLUSION: UR may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-gamma production. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19429328/Oral_administration_of_Uncariae_rhynchophylla_inhibits_the_development_of_DNFB_induced_atopic_dermatitis_like_skin_lesions_via_IFN_gamma_down_regulation_in_NC/Nga_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00698-3 DB - PRIME DP - Unbound Medicine ER -