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Anti-inflammatory and phytochemical properties of twelve medicinal plants used for treating gastro-intestinal ailments in South Africa.
J Ethnopharmacol. 2009 Jun 22; 123(2):237-43.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The investigated medicinal plants are commonly used for the treatment of pains and cramps related to gastro-intestinal tract infections in South African traditional medicine.

AIMS OF THE STUDY

This study aimed to evaluate the ability of the plant extracts to inhibit cyclooxygenase enzymes. Phytochemical analysis was also carried out in the quest to determine some plant metabolites that may be responsible for the observed anti-inflammatory activity.

MATERIALS AND METHODS

The cyclooxygenase assay was used to test for the anti-inflammatory activity of the plant extracts using cyclooxygenase-1 and -2 (COX-1 and COX-2) enzymes. Total phenolic compounds including condensed tannins, gallotannins and flavonoids were quantitatively determined using spectrophotometric methods. Qualitative tests for alkaloids and saponins were also carried out.

RESULTS

Most of the plant extracts evaluated showed dose dependent activity against COX-1 and/or COX-2 enzymes. Agapanthus campanulatus root dichloromethane extract showed the highest COX-2 inhibitory activity (83.7%) at 62.5 microg/ml. The presence and/or amounts of phenolics, condensed tannins, gallotannins, flavonoids, alkaloids and saponins varied with plant parts and species.

CONCLUSION

The results support the use of the investigated plant in treating pain and cramp related to gastro-intestinal tract infections. To some extent, the observed anti-inflammatory activity could be attributed to the various plant secondary metabolites detected in the plant materials.

Authors+Show Affiliations

Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19429367

Citation

Fawole, O A., et al. "Anti-inflammatory and Phytochemical Properties of Twelve Medicinal Plants Used for Treating Gastro-intestinal Ailments in South Africa." Journal of Ethnopharmacology, vol. 123, no. 2, 2009, pp. 237-43.
Fawole OA, Ndhlala AR, Amoo SO, et al. Anti-inflammatory and phytochemical properties of twelve medicinal plants used for treating gastro-intestinal ailments in South Africa. J Ethnopharmacol. 2009;123(2):237-43.
Fawole, O. A., Ndhlala, A. R., Amoo, S. O., Finnie, J. F., & Van Staden, J. (2009). Anti-inflammatory and phytochemical properties of twelve medicinal plants used for treating gastro-intestinal ailments in South Africa. Journal of Ethnopharmacology, 123(2), 237-43. https://doi.org/10.1016/j.jep.2009.03.012
Fawole OA, et al. Anti-inflammatory and Phytochemical Properties of Twelve Medicinal Plants Used for Treating Gastro-intestinal Ailments in South Africa. J Ethnopharmacol. 2009 Jun 22;123(2):237-43. PubMed PMID: 19429367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and phytochemical properties of twelve medicinal plants used for treating gastro-intestinal ailments in South Africa. AU - Fawole,O A, AU - Ndhlala,A R, AU - Amoo,S O, AU - Finnie,J F, AU - Van Staden,J, Y1 - 2009/03/24/ PY - 2008/12/23/received PY - 2009/03/05/revised PY - 2009/03/11/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/7/21/medline SP - 237 EP - 43 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 123 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The investigated medicinal plants are commonly used for the treatment of pains and cramps related to gastro-intestinal tract infections in South African traditional medicine. AIMS OF THE STUDY: This study aimed to evaluate the ability of the plant extracts to inhibit cyclooxygenase enzymes. Phytochemical analysis was also carried out in the quest to determine some plant metabolites that may be responsible for the observed anti-inflammatory activity. MATERIALS AND METHODS: The cyclooxygenase assay was used to test for the anti-inflammatory activity of the plant extracts using cyclooxygenase-1 and -2 (COX-1 and COX-2) enzymes. Total phenolic compounds including condensed tannins, gallotannins and flavonoids were quantitatively determined using spectrophotometric methods. Qualitative tests for alkaloids and saponins were also carried out. RESULTS: Most of the plant extracts evaluated showed dose dependent activity against COX-1 and/or COX-2 enzymes. Agapanthus campanulatus root dichloromethane extract showed the highest COX-2 inhibitory activity (83.7%) at 62.5 microg/ml. The presence and/or amounts of phenolics, condensed tannins, gallotannins, flavonoids, alkaloids and saponins varied with plant parts and species. CONCLUSION: The results support the use of the investigated plant in treating pain and cramp related to gastro-intestinal tract infections. To some extent, the observed anti-inflammatory activity could be attributed to the various plant secondary metabolites detected in the plant materials. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19429367/Anti_inflammatory_and_phytochemical_properties_of_twelve_medicinal_plants_used_for_treating_gastro_intestinal_ailments_in_South_Africa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(09)00153-6 DB - PRIME DP - Unbound Medicine ER -