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Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity.
J Ethnopharmacol. 2009 Jun 22; 123(2):280-7.JE

Abstract

AIMS OF THE STUDY

Fatty liver is the most common cause of abnormal liver function tests. We investigated the effect and its underlying mechanism of pomegranate flower (PGF), a traditional antidiabetic medicine, on fatty liver.

MATERIALS AND METHODS

At the endpoint of treatment of male Zucker diabetic fatty (ZDF) rats with PGF extract (500 mg/kg, p.o. x 6 weeks), liver weight index, hepatic lipid contents (enzymatic colorimetric methods) and droplet accumulation (Oil Red O staining) were determined. Gene profiles (RT-PCR) were analyzed in the liver of ZDF rats and in human liver-derived HepG2 cell line.

RESULTS

PGF-treated ZDF rats showed reduced ratio of liver weight to tibia length, hepatic triglyceride contents and lipid droplets. These effects were accompanied by enhanced hepatic gene expression of peroxisome proliferator-activated receptor (PPAR)-alpha, carnitine palmitoyltransferase-1 and acyl-CoA oxidase (ACO), and reduced stearoyl-CoA desaturase-1. In contrast, PGF showed minimal effects on expression of genes responsible for synthesis, hydrolysis or uptake of fatty acid and triglycerides. PGF treatment also increased PPAR-alpha and ACO mRNA levels in HepG2 cells.

CONCLUSION

Our findings suggest that this Unani medicine ameliorates diabetes and obesity-associated fatty liver, at least in part, by activating hepatic expression of genes responsible for fatty acid oxidation.

Authors+Show Affiliations

Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19429373

Citation

Xu, Kevin Zhe-Yang, et al. "Pomegranate Flower Ameliorates Fatty Liver in an Animal Model of Type 2 Diabetes and Obesity." Journal of Ethnopharmacology, vol. 123, no. 2, 2009, pp. 280-7.
Xu KZ, Zhu C, Kim MS, et al. Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity. J Ethnopharmacol. 2009;123(2):280-7.
Xu, K. Z., Zhu, C., Kim, M. S., Yamahara, J., & Li, Y. (2009). Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity. Journal of Ethnopharmacology, 123(2), 280-7. https://doi.org/10.1016/j.jep.2009.03.035
Xu KZ, et al. Pomegranate Flower Ameliorates Fatty Liver in an Animal Model of Type 2 Diabetes and Obesity. J Ethnopharmacol. 2009 Jun 22;123(2):280-7. PubMed PMID: 19429373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity. AU - Xu,Kevin Zhe-Yang, AU - Zhu,Chenchen, AU - Kim,Moon Sun, AU - Yamahara,Johji, AU - Li,Yuhao, Y1 - 2009/04/01/ PY - 2008/08/28/received PY - 2009/03/03/revised PY - 2009/03/07/accepted PY - 2009/5/12/entrez PY - 2009/5/12/pubmed PY - 2009/7/21/medline SP - 280 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 123 IS - 2 N2 - AIMS OF THE STUDY: Fatty liver is the most common cause of abnormal liver function tests. We investigated the effect and its underlying mechanism of pomegranate flower (PGF), a traditional antidiabetic medicine, on fatty liver. MATERIALS AND METHODS: At the endpoint of treatment of male Zucker diabetic fatty (ZDF) rats with PGF extract (500 mg/kg, p.o. x 6 weeks), liver weight index, hepatic lipid contents (enzymatic colorimetric methods) and droplet accumulation (Oil Red O staining) were determined. Gene profiles (RT-PCR) were analyzed in the liver of ZDF rats and in human liver-derived HepG2 cell line. RESULTS: PGF-treated ZDF rats showed reduced ratio of liver weight to tibia length, hepatic triglyceride contents and lipid droplets. These effects were accompanied by enhanced hepatic gene expression of peroxisome proliferator-activated receptor (PPAR)-alpha, carnitine palmitoyltransferase-1 and acyl-CoA oxidase (ACO), and reduced stearoyl-CoA desaturase-1. In contrast, PGF showed minimal effects on expression of genes responsible for synthesis, hydrolysis or uptake of fatty acid and triglycerides. PGF treatment also increased PPAR-alpha and ACO mRNA levels in HepG2 cells. CONCLUSION: Our findings suggest that this Unani medicine ameliorates diabetes and obesity-associated fatty liver, at least in part, by activating hepatic expression of genes responsible for fatty acid oxidation. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19429373/Pomegranate_flower_ameliorates_fatty_liver_in_an_animal_model_of_type_2_diabetes_and_obesity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(09)00145-7 DB - PRIME DP - Unbound Medicine ER -